Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Chromatin Regulation by RNA Methylation
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Gaining New Perspectives on Chromatin Interactions Through Heterotypic Nucleosomes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:00 pm
"Nucleic Acids Chemical Labeling"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemistry of Modified Nucleosides and Nucleotides
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Cyclic Oligonucleotides- Fascinating Molecules and New Therapeutic Opportunities"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"New Strategies and Tactics for the De Novo Synthesis of Nucleosides and Nucleoside Analogues"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Chemistry of Modified Nucleosides and Nucleotides"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"3'-Deoxy-3',4'-Didehydro-Nucleosides and ProTides as Potent Antiviral Agents"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Structure and Function
7:30 pm - 7:55 pm
"RNA Switches in Viral and Human Genomes: Uncovering Hidden Regulatory Elements"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Expand the Alphabet and Topology of Synthetic mRNAs for Therapeutics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Structure-Based Discovery and Manipulation of New Functions in Large RNAs"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Non-Canonical Structures of Nucleic Acids
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"CUT&Tag Genome-Wide Mapping in Mycobacterium Tuberculosis Reveals an Unconventional G-Quadruplex Landscape"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"G-Quadruplex-Forming Aptamers for Biomedical Applications"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"G4 RNA Structures and Their Contribution to Stress Response"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Drug Targeting and Protein Recognition of Oncogene DNA G-Quadruplex"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis and Sequencing of Native and Modified Oligonucleotides
7:30 pm - 7:55 pm
"RNA Direct Nanopore Sequencing Reveals Chemical Changes to Cellular rRNA During Stress"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Enzymatic De Novo Synthesis of 1000-Mer Oligonucleotides"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"RNA Oligonucleotide Manufacturing Using Engineered Enzymes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acid Chemistry for Therapeutics, Probes, and Model Systems
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Click to Control RNA Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Design of Fluorogenic Probes for RNA Sensing and Imaging: Small Molecules, Triplex-Forming Peptide Nucleic Acids and Light-Up Peptides "
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Base-Modified and Hypermodified DNA, RNA and XNA for Chemical Biology and Selection of Functional Nucleic Acids"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"All About "To B or Not To B " in Nucleic Acids Chemistry"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CRISPR DNA and ADAR RNA Editing
7:30 pm - 7:55 pm
"Development and Characterization of Precision Genome Editing Tools"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Exploring the Evolution of RNA-Guided Systems Towards the Development of Molecular Tools"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Therapeutic Applications for Hepatic and Extrahepatic RNA Editing via Endogenous ADAR Enzymes"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Nucleic Acid Therapeutics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Chemical Engineering of RNA Therapeutics for CNS Manipulation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"We Need New Chemistry to Address the Endosomal Escape Problem"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"A Structure-Based Approach to Drugging RNA with Small Molecules"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Modifications of mRNA Ends to Boost mRNA Therapeutics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Biology of Modified Oligonucleotides
7:30 pm - 7:55 pm
"The Origin of Biomolecules on the Early Earth"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Nucleic Acid Chemistry with Light"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Chemical Sensing and Biological Regulation by Riboswitches"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure