Nucleosides, Nucleotides and Oligonucleotides (GRS)

Gordon Research Seminar

Chemical Biology and Clinical Applications of Nucleosides, Nucleotides and Oligomers

June 24 - 25, 2023

Chairs

and

Salve Regina University

36 Ochre Point Avenue

Newport, Rhode Island, United States

Venue and Travel Information

Conference Description

The Nucleosides, Nucleotides and Oligonucleotides GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The focus of this meeting is to highlight advances in the field of nucleosides, nucleotides, and oligonucleotides. Speakers will discuss chemical biology, synthesis, structure, and therapeutic applications of natural and engineered small molecules and oligomers. The scientific program will feature three themed sessions including a keynote lecture and mentorship panel comprised of diverse representatives from academia and industry to facilitate career development of participants.

Related Meeting

This GRS will be held in conjunction with the "Nucleosides, Nucleotides and Oligonucleotides" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Welcome to Chemical Biology and Clinical Applications of Nucleosides, Nucleotides and Oligomers Discussion Leader:
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:20 pm	"Illuminating 1,000-Fold Regulation of Translation to Engineer mRNA Medicines"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Structure and Function of Natural and Synthetic Macromolecules Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:45 pm	"Development of Photocaged Amino Acid Sidechain Peptide Nucleic Acid (PNA) Monomers to Enable Rapid Modulation of Assembly State"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	"Affinity-Based Profiling of the Flavin Mononucleotide Riboswitch"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:15 pm	"Monitoring Cellular Delivery of PNA-Peptide Conjugates"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:30 pm	"tRNA Fragment Analogs as a Potential Therapeutic for Cancers and ALS/FTD"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"Automated High-Throughput Selection of Aptamers Using a Modified Optical Next-Generation Sequencer"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"TMPRSS2-ERG and AR Circulating mRNA Detection for Prostate Cancer Prognosis Using a Lab-on-Chip Device"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"Determining the Affinity of Various Capped RNAs for the IFIT1 Protein Using Microscale Thermophoresis"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Chemical Biology and Engineering of Small Molecules Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:15 am	"Modified Flex-Acyclovir Analogues: A Journey to Discovering Broad-Spectrum Antiviral Therapeutics"
9:15 am - 9:20 am	Discussion
9:20 am - 9:30 am	"Design and Synthesis of Novel D-Ribose Flex-Nucleoside Analogues and Evaluation as Antiviral Therapeutics Agents"
9:30 am - 9:35 am	Discussion
9:35 am - 9:45 am	"Establishing a Chemical Biological Toolbox to Understand the Mechanisms of Splice-Switching Small Molecules"
9:45 am - 9:50 am	Discussion
9:50 am - 10:00 am	"Probing the Chemical Space Tolerance and Processivity of DNA Polymerases in Real Time and 3D Using Responsive Fluorescent Nucleotide Analogs"
10:00 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Inosine and Reverse Transcriptases"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Exploring the Kinetics of Quinone Methide (QM) Transfer Along DNA with 1,8-Naphthalimide Intercalating Agent"
10:30 am - 10:35 am	Discussion
10:35 am - 10:45 am	"Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding"
10:45 am - 10:50 am	Discussion
10:50 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Insights into the State of Careers in Academia and Industry Discussion Leader:
1:30 pm - 1:35 pm	Introduction by Discussion Leader
1:35 pm - 2:30 pm	Panel Discussion Navigating Careers in Academia and Industry
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI174632. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Nucleosides, Nucleotides and Oligonucleotides

Similar Conferences