Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Channels and Metabolite Transporters in Chloroplasts
This session will focus on the link between ion/metabolite transport and the regulation of chloroplast function.
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
"Thylakoid K+ and Cl- Channels and Transporters Regulate Photosynthesis in Fluctuating Light"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"The Transporter PAM71, Crucial for Manganese Delivery to Maintain Optimal Photosynthesis, Is Present in Plants and in Humans"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The K+ /Na+ Interplay in Arabidopsis kea1kea2 Mutants - New Insights into Cellular and Subcellular Ion Homeostasis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"What Drives Ion Transport Across the Thylakoid Membrane?"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Solute Transport and Signaling in Mitochondria from Animals and Plants
This session addresses outstanding questions in mitochondrial physiology.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Mitochondrial Regulation of Mitochondrial Potassium Channels"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"New Turns on Fundamental Metabolism: Regulation of Cori Cycle Dynamics by the Mitochondrial Pyruvate Carrier"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Safety Upgrade of the Mitochondrial Calcium Uniporter Complex"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Mitochondrial ATP-Sensitive Potassium Channels (mitoKATP): Molecular Identity and Physiological Role"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"VDAC2-BAK Axis Regulates Peroxisomal Membrane Permeability and Catalase Release"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"SK Channels Prevent Neurotoxicity in Conditions of Enhanced ER Mitochondrial Coupling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Malate Transport in Mitochondria Is Regulated Diurnally by Two Dicarboxylate Carriers in Arabidopsis "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Methodologies: Unraveling Intracellular Fluxes with Novel Specific Probes
Innovative approaches to detect ion and metabolites fluxes across intracellular membranes in vivo .
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Intracellular Sites of Trace Metal Accumulation in Eukaryotes"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"In Vivo Calcium Dynamics in Plant Cells: A Holistic View"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Novel Local RyR1 Junctional Calcium Responses and Dynamics by Improved Calcium Sensor CatchER"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Secretory Granule Protein Chromogranin B Forms a Novel Chloride Channel in Membrane"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Optically Recording of Intracellular Zinc Release from Lysosomes"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Channels/Transporters in Exo/Endo-Cytosis Pathways
This session covers vesicular and lysosomal ion channels with special emphasis on pathological links.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"How to Fill a Vesicle in 30 Seconds? Uptake Mechanisms for Amino Acid Neurotransmitters"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Protons to Patients: Evaluating the Role of the Chloride Transporter ClC-7 in Lysosomal Function"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Identification of OCaR1 as a Gatekeeper of Lysosomal-Granular Ca2+ Release and Regulated Exocytosis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"TM9SF4 Is a Novel Organelle Potassium Channel Crucial for Starvation-Induced Autophagy in Mammalian Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Acidification Mechanisms in Intracellular Organelles"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanism of Fatty Acid Transport by the Peroxisomal ABC Transporter COMATOSE (CTS/AtABCD1)"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Lysosomal Localization and Function of TTYH Transporters"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cross-Talk Between Organelles and Different Channels/Transporters
Highlighting novel players in the organellar network in animals and photosynthetic organisms.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Ion Channels in the Intracellular Vesicles"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Calcium Signal Propagation Between Endoplasmic Reticulum and Mitochondria"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Cross Talk Between Chloroplast and Mitochondria in Microalgae: A Critical Analysis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Optical Control of Membrane Tethering and Inter-Organellar Communications"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Pathophysiology of Intracellular Channels and Transporters
Targeting various pathologies via modulation of ion fluxes.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Endolysosomal Two-Pore Channels in Normal Physiology and Disease"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
10:05 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"VDAC1 as a Target: Crossing the Aisle from Cancer to Neurodegeneration and Diabetes"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Melanosomal Ion Channels Critical for Pigmentation"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Negative Feedback Regulation of mTOR Activity by the Lysosomal Ca2+ Channel TRPML1 Using a Calmodulin-Dependent Mechanism"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"TMCO1 Is an ER Ca2+ Load-Activated Ca2+ (CLAC) Channel"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Contribution of F-ATP Synthase Subunits to Formation and Modulation of the Permeability Transition Pore - Mitochondrial Megachannel"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondrial Calcium Uniporter Controls AMPK Activity and Lipid Metabolism"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Ion Transport in Vacuoles
Impact of ion and small-molecule transport on the physiology of vacuoles.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"The Role of the Vacuolar ALMT Anion Channels in Stomata Movement and Salt Tolerance"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Molecular Mechanism of Sugar Transport by the SWEET Family Transporter"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Structure of the Vacuolar TPC1 Channel from Arabidopsis thaliana "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Arabidopsis MATE-Type Anion Channels and Their Function in Turgor Regulation"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Channels/Transporters of the Endoplasmatic Reticulum and Nucleus
Speakers in this session use cutting edge approaches to uncover structure/function of old and new transporters in animals and plants.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Structural Basis of Calcium Activation of Ryanodine Receptor"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Intracellular TRIC Channels: Electrophysiological and Pathophysiological Characterization"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Molecular Mechanism of the IP3 -Activated Calcium Release Channel: Insights from Cryo-EM Studies"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Nuclear Calcium Signalling"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"A ER-Localized Anion Channel Regulates Internal Calcium Release"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Regulation of Intracellular Calcium Dynamics by a Novel Leak Channel in ER"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondria Control Store-Operated Ca2+ Entry Through Na+ and Redox Signals"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Organellar Channels and Transporters
The keynote session will link new proteins to organellar transport function.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:30 pm
"Biogenesis of Mitochondrial Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Protein Translocases in the Inner Envelope Membrane of Chloroplasts"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"CLIC5 Localizes to the Inner Mitochondrial Membrane and Modulates Its Cardiac Mitochondrial Reactive Oxygen Species"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure