Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Groundbreaking Discoveries in Organellar Channels and Transporters
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Mechanisms of Mitochondrial H+ Leak"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Identification of Specialized Metabolite Exporter Assigns a New Role to Transporter Family"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"A Heart Felt Tale of Two ANTS"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Dynamic Mitochondrion and Chloroplasts
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Mitochondrial Calcium Uniporter Compensates for Complex I Dysfunction"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Mitochondrial Potassium Channel-Linked Signaling Events Profoundly Alter Cancer Cell Behavior"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"The Liver Mitochondrial Dicarboxylate Carrier Regulates Whole-body Glucose Homeostasis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Synchronization of Photosynthetic Reactions by Thylakoid Ion Transport"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Management and Function of Mitochondrial Ca2+ Uptake in Plants"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Structural Basis of Metabolite Transport by the Chloroplast Outer Envelope Channel OEP21"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Relationship between the Mitochondrial BKCa Channel and the Cellular Redox State"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Physiology of Mitochondrion and Chloroplasts
6:00 pm - 6:20 pm
"Cellular Iron Compartmentalization Mechanisms in Plants"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Mitochondrial Dysfunction Mediated by ER-Calcium Dysregulation in Alzheimer’s Disease"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Ca2+ Exchange at the ER-Mitochondrial Interface and its Effect on Cell Proliferation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"The Role of the Mitochondrial Potassium Channels in Damage Caused by Urban Particulate Matters"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Plant FAX Proteins - The Flow of Fatty Acids from Chloroplasts to ER (and Beyond?)"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Master Regulator of Membrane Trafficking and Cellular Calcium: Endoplasmic Reticulum and Golgi Apparatus
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Structure and Dynamics of the Ryanodine Receptor"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"A New Look at Ca2+ Handling Within ER-PM Signaling Units"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Proton-Gated Anion Transport Governs Macropinosome Shrinkage"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"IP3 Receptor-Mediated Calcium Signaling in Health and Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Transport and Homeostasis of Calcium and Manganese in Compartments of the Plant Secretory Pathway"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Structure-Function Analysis of the Yeast Golgi-Localized Ca2+-Mn2+/H+ Gdt1p Transporter"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Light-Gated ChannelRhodopsin Powers Proton-Induced Calcium Release"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Physiology of Endoplasmic Reticulum and Golgi Apparatus
6:00 pm - 6:20 pm
"Non Canonical Functions of STIM Proteins in Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Irreversible Processes for Exquisite Temperature Sensitivity of TRP Channels"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Optogenetics Provide New Insight into the Molecular Mechanism of Ca2+ Signaling in Stomatal Guard Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Structural Dynamics of Adenine Nucleotide Potentiation of Human IP3 Receptor Type 2"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The Golgi Calcium ATPase in Health and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Concepts: Vesicle and Vacuoles
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Discovery of a New Proton-Activated Chloride (PAC) Channel and Its Surprising Role in Endosomes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Study of Vacuole Glycerate Transporter NPF8.4 Reveals a New Role of Photorespiration in N Flux"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Direct Measurements of Luminal Ca2+ with Endo-Lysosomal GFP-Aequorin (ELGA) Reveal Functional IP3 Receptors"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"The V-ATPase - a Proton Pump for Vesicles and Vacuoles"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Membrane Transporters of the Yeast Vacuole"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Role of the Vacuole on Ca2+ Homeostasis and Generation of Ca2+ Signals in Plant Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Lysine Trafficking and Compartmentalization in the Yeast Vacuole"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Physiology of Vesicle and Vacuoles
6:00 pm - 6:20 pm
"Proton Release Mechanisms in the Lysosome"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Sterol Homeostasis in Vacuoles of Saccharomyces Cerevisiae Mediated by Niemann-Pick Type C Related Protein 1"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"TRPML3: An Endolysosomal Cation Channel in Lung Emphysema and COPD"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Lysosomal LRRC8 Complex Regulates Nutrient-Stimulated mTOR Signaling"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Organellar Ca2+ Regulators (OCaRs) determining NAADP-Mediated Ca2+ Release from Acidic Intracellular Stores in Pancreatic Acinar Cells and Cardiomyocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Chloride Intracellular Channel 1 as a Privilege Receptor Mediating Metformin Antiproliferative Action on Glioblastoma Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Structural and Functional Studies of TRPML1 in Situ"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"An Exosomal Large Conductance Calcium-Activated Potassium Channel Regulates its Cargo and Function"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Lysosomal pH Regulation by LAMP-1 and LAMP-2"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"The Nuclear Envelope Architecture in Arrhythmogenic Cardiomyopathy"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Pulse-Labelling Mass Spectrometry Reveals Age-Dependent Compositional Plasticity of the Yeast Nuclear Pore Complex"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"OSMR Interactome Mapping Reveals the Significance of a Chloride Channel in Cytokine Regulation and Glioblastoma Progression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intracellular Ion Channel Physiology and Novel Techniques
6:00 pm - 6:20 pm
"Development of Artificial Ion Channels to Target Cancer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Primary Cilia Ion Channels as Regulators of Hippocampal Excitability"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"The Mitochondrial Kv1.3 Channel"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Structural Analysis and Aggregation of Proteins in Solution and Poration of Endosomal Membranes by a Comparative Study using Dissipative Particle Dynamics and Molecular Dynamics"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Stress is Basic: The Role of Vascular Bundle Sheath Cells' V-H+ ATPase and P-H+ ATPase Pumps in Regulating Leaf Hydraulics via Blue Light and ABA Opposing Signals"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure