6:00 p.m. Dinner

7:15 Welcome & Introductory Remarks

Session 1 Bill Berkowitz, Queens’ College, New York City - Discussion Leader

7:30 p.m. Nanette M Wachter-Jurcsak, Hofstra University “Preparation and Properties of N,N-Dimethylamino Substituted Flavanoids”

8:15 Discussion

8:30 Break

8:45 Leland O Weigel, Eli Lilly & Company “New Synthesis Methods for Non-Racemic Benzo[f]quinalinones: Clinically Important 5-d-Reductase Inhibitors “

9:20 Discussion

6:30 a.m. Breakfast

Session 2 Chris Schmid, Eli Lilly & Company - Discussion Leader

8:15 a.m. Announcements

8:30 Alcide Perboni, Glaxo Wellcome S.p.A. “Process Research & Scale-up of the Synthesis of the 4- Formamidino Substituted Trinem, GV129606X”

9:15 Discussion

9:30 Goege Wu, Schering Plough “A Novel One-Step Diastereo- and Enantioselective Formation of trans-Azetidinones and its Application to the Total Synthesis of Cholesterol Absorption Inhibitors”

10:05 Discussion

10:15 Break

Session 3 Greg Reid, Advanced American Organics - Discussion Leader

10:30 a.m. Kevin Babiak, G.D. Searle “Optimization of a Process to Make an Unusual ?-Aminobutyrolactam, A Key Intermediate for Orbofiban”

11:05 Discussion

11:15 Keith DeVries, Pfizer, Inc. “The Preparation of ß-Substituted Amines from Regioisomeric Mixtures of Epoxide Opening Products via a Common Aziridinium Ion Intermediate: Application to a Drug Candidate”

11:50 Discussion

12:00 Lunch

4:00 - 6:00 Poster Session 1

6:00 Dinner

Session 4 Cindy Maryanoff, R. W. Johnson Pharm. Research - Discussion Leader

7:15 p.m. Tim Watson, Hoechst Marion Roussel “Chemical Development of MDL 103371: an N-methyl-D- aspartate (NMDA)-type Glycine Receptor Antagonist for the Treatment of Stroke”

7:50 Discussion

8:00 Ed Delaney, Bristol Myers Squibb “Reassessment of N-Trifluoroacetylation as a Protection Strategy in Amino Acid Coupling Reactions”

8:35 Discussion

8:45 Break

9:00 Mukund Sibi, North Dakota State University “The Role of Achiral Templates in Enantioselective Transformations”

9:45 Discussion

6:30 a.m. Breakfast

Session 5 Steve King, Abbott Laboratories - Discussion Leader

8:15 a.m. Photo Session - BE PROMPT

8:45 Announcements

9:00 Amir Hoveyda, Boston College “Recent Advances in Asymmetric Catalysis”

9:45 Discussion

10:00 Joe Armstrong, Merck & Co., Inc. “An Efficient Asymmetric Synthesis of a Growth Hormone Secretagogue”

10:35 Discussion

10:45 Break

Session 6 Gerald Hammond, University of Massachusetts - Discussion Leader

11:00 a.m. Mike O’Brien, Rhone-Poulenc Rorer “Novel Approaches to an Industrial Process for the Preparation of Adenosine Agonist with Five Chiral Centers”

11:35 Discussion

11:45 Bruce Maryanoff, R.W. Johnson Pharm.Research “Control of Stereocenters Separated by Four or More Bonds in Strictly Acyclic Substrates”

12:20 Discussion

12:30 Lunch

1:30 3rd Annual OR&P Golf “Classic”

Session 7 Mike Lipton, Pharmacia & UpJohn - Discussion Leader

7:15 p.m. Xuma Zhang, Penn State University “Developing a Chiral Toolbox for Asymmetric Catalytic Reactions”

8:00 Discussion

8:15 Break

8:30 Nick Magnus, Dupont Pharmaceuticals “Synthesis of Cyclic Urea HIV Drug Candidates”

9:05 Discussion

9:15 Rob Leanna, Abbott Laboratories “Synthesis of a Novel Anti-Infective Agent”

9:50 Discussion

10:00 Business Meeting and Nominations

6:30 a.m. Breakfast

Session 8 Jim Behling, G.D. Searle- Discussion Leader

8:15 a.m. Announcements

8:30 Vic Snieckus, Queen’s University “From Flatland to Prochiral Metalation”

9:15 Discussion

9:30 Jack Brown, Roche Colorado “From Laboratory to 12,000 liters. A Chemist’s Perspective”

10:05 Discussion

10:15 Break and Election of Chair for 2001

Session 9 Shon Pulley, University of Missouri-Columbia - Discussion Leader

10:30 Neil Baine, SmithKline Beecham “The Evolution of a Cost Effective Synthesis-from Route Discovery to Manufacturing”

11:05 Discussion

11:15 a.m. Larry Truesdale, Alanex Corporation “Process Chemistry before Discovery Chemistry?”

11:50 Discussion

12:00 Lunch

4:00 - 6:00 Poster Session 2

6:00 Dinner

Session 10 Don Hou, Schering Plough Research - Discussion Leader

7:10 p.m. Election Results

7:15 Wilfried Hoffmann, Warner Lambert “Use of RC1/ReactIR in Chemical Development”

7:50 Discussion

8:00 Peter Wuts, Pharmacia & Upjohn “Synthesis of PNU-95666E”

8:35 Discussion

8:45 Break

9:00 Mikiko Sodeoka, Sagami Chemical Research “Catalytic Enantioselective Reactions via Palladium Enolates”

9:45 Discussion

6:30 a.m. Breakfast

Session 11 Rich Pariza, CP Consulting, Inc. - Discussion Leader

8:15 a.m. Announcements

8:30 Günther Helmchen, University of Heidelberg “Recent Progress in Asymmetric Allylic Substitutions”

9:15 Discussion

9:30 Nizar Haddad, Boehringer Ingelheim Pharmaceuticals “New Synthetic Applications of the Photocycloadditions of Cyclic Enomes to Alkeness”

10:05 Discussion

10:15 Break

Session 12 Susan Ensel, Hood College

10:30 a.m. Dave Mootoo, Hunter College “A Convergent, DeNova Approach to the Synthesis of Complex Glycomimetics”

11:05 Discussion

11:15 Randy Halcomb, University of Colorado “Application of Novel Annulation Reactions to the Synthesis of Natural Products”

11:50 Discussion

12:00 Lunch

2:00 Annual Academic/Industrial Softball Game

4:00 - 6:00 Chair’s Reception - Wine Tasting

6:00 Dinner

Session 13 Michael Harmata - Discussion Leader

7:30 p.m. Michael Behe, Lehigh University “The Challenge to Darwinian Evolution”

8:30 Discussion

9:00 Closing Remarks