Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Anionic Cascade Adventures: From Strained Rings to Atropisomers with Fun Discoveries Along the Way"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Stereoselective Reactions with Feedstock Chemicals"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reaction Mechanisms and Strategies in Process Research
9:00 am - 9:30 am
"Synthetic Strategies Leveraging Fluoride-Enabled Reactivity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Iron-Catalyzed Radical Cross-Couplings: A General Platform for Selective Alkene Difunctionalization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Advancements in Process Chemistry for a KRAS G12C Inhibitor: Refining Synthetic Approaches for Critical Building Blocks and Final Assembly"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Robustness in Chemical Processes: Mechanistic Patterns from Case Studies"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Kinetic and Mechanistic Studies Guide Development of a Scalable Sulfonamide Synthesis for AMG 650"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis of Complex Bioactive Molecules
7:30 pm - 8:00 pm
"Development of a Continuous Process and Manufacturing System for the Kilogram-Scale Preparation of an Advanced Drug Substance Intermediate"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Development of an Efficient, Robust Process for Oral PCSK9 Inhibitor MK-0616"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Small Rings Doing Big Jobs: New Routes to Beta-Lactones"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reactions and Processes for a Sustainable Future
9:00 am - 9:30 am
"Biocatalysis for the Masses: Including Enzymes in Your Chemistry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Chemoenzymatic Synthesis of Medicinally-Relevant, sp3 -Rich Molecules"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Sustainability Improvements for Solid-Phase Peptide Synthesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Green-By-Design Development of the Second-Generation Route to Camlipixant"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Your Chemistry Has Got Potential: Highly Reactive Intermediates Without the “Bang”"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalytic and Asymmetric Methods in Chemical Synthesis
7:30 pm - 8:00 pm
"Harnessing Cyclopropenimines for Catalyst Design in Stereoselective Synthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Nickel-Catalyzed C-N and C-O Cross-Couplings Enabled by DalPhos Ligation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Choose Your Own Adventures in Catalysis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Strategies and Methodologies for Synthesis
9:00 am - 9:30 am
"Synthesis of Nitrogen Heterocycles Through Transition Metal-Catalyzed Heteroarene Dearomatization"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"New Synthetic Methods Using Photochemistry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The Development of Multi-ton GMP Flow Processes for the Pharmaceutical Industry"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Commercial Route Development of an Active Pharmaceutical Ingredient"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"New Tools in Sulfur-Fluorine Exchange (SuFEx)"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis of and with Heterocycles
7:30 pm - 8:00 pm
"Challenges and Opportunities for Large Scale Syntheses of Heterocycles in the Agrochemical Industry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Deaminative Cross-Couplings"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Radical Approaches to Bond Formation and Selected Poster Talks
9:00 am - 9:30 am
"Photomediated Strategies for Engaging Non-Traditional Radical Precursors in Organic Synthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Electrochemical Methods for C–C and C–X Cross Coupling Reactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Academic Drug Discovery
7:30 pm - 8:20 pm
"The Role of Medicinal Chemistry in the Search for New Therapeutic Agents: Natural Products vs Peptides"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
"YCT-529 A Male Contraceptive: The Path from Discovery to the Clinic"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure