SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
7:45 pm - 8:00 pm | Introductory Remarks by Co-Chairs: Julie Andersen and Michael Brownlee |
8:00 pm - 9:30 pm | Keynote Presentation |
8:00 pm - 9:00 pm | Flint Beal (Medical College of Cornell) "Novel Approaches to Oxidative Damage in Neurodegenerative Diseases" |
9:00 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Oxidative stress, DNA damage, epigenetics and disease |
9:00 am - 9:15 am | Discussion Leader: Kelvin Davies (University of Southern California, CA) |
9:15 am - 9:45 am | Judy Campisi (Buck Institute, CA) "The senescence response to oxidative and genotoxic stress: a link between aging and age-related disease" |
9:45 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Jan Vijg (Albert Einstein College of Medicine, NY) "Genome dynamics in aging" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Michael Rosenfeld (University of California, San Diego, CA) "Regulatory Roles of the Subnuclear Social Network" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | General Discussion (sessions #1 and #2) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oxidative stress and transcriptional regulation in disease |
7:30 pm - 7:40 pm | Discussion Leader: Henry Forman (University of California, Merced) |
7:40 pm - 8:05 pm | Raj Ratan (Weill Medical College of Cornell) "Oxidative Stress, Transcriptional Regulation, and Neuronal Injury: Towards
Development of Novel Therapeutics" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Noel Buckley (King’s College London) "Transcriptional dysregulation of coding and non-coding genes in Huntington’s disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | King Jordon (Georgia Institute of Technology) "Computational epigenomics: new approaches in genome informatics" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Oxidative stress, miRNAs, and disease |
| Discussion Leader: TBA |
9:00 am - 9:30 am | Myriam Gorospe (LMBI, NIA-IRP, NIH, Baltimore, MD) "Oxidant-regulated gene expression by mRNA-binding factors" |
9:30 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Coffee Break |
10:20 am - 10:50 am | Marai Mouradian (UMDMJ, NJ) "Protective role of mRNAs in models of Parkinson’s disease" |
10:50 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Tim Oury (University of Pittsburgh, PA) "Oxidative stress in the extracellular matrix: implications for inflammation and fibrosis" |
11:35 am - 11:55 am | Discussion |
11:55 am - 12:30 pm | General Discussion (sessions #3 and #4) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oxidative stress, stem cells, and disease |
| Discussion Leader: Victoria Lunyak (Buck Institute, CA) |
7:30 pm - 8:00 pm | Victoria Lunyak (Buck Institute, CA) "Retrortansposons and aging of human adult mesenchymal stem cells" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Anne Brunet (Stanford University, CA) "FOXO transcription factors in aging and longevity" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Sykes (Massachusetts General Hospital and Harvard University, MA) "Unexpected role for FOXOs in leukemic stem cells" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Oxidative stress and alterations in mitochondrial dynamics in disease |
9:00 am - 9:15 am | Discussion Leader: Tim Greenamyre (University of Pittsburgh Medical Center, PA) |
9:15 am - 9:45 am | Charleen Chu (University of Pittsburgh) "Autophagy and mitochondrial control in genetic models of Parkinson’s disease" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Teresa Hastings (University of Pittsburgh, PA) "Dopamine oxidation and quinone modification of mitochondrial proteins: Implications for Parkinson's disease" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:45 am | John LeMasters (Medical University of South Carolina) "Iron Translocation from Lysosomes to Mitochondria in Oxidant Stress-Induced Cell Injury" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | General Discussion (sessions #5 and #6) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting (Vice Chairs Enrique Cadenas and Tilman Grune) |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Short talks from posters/late-breaking advances |
| Discussion Leaders: Enrique Cadenas (University of Southern California, CA)and Tilman Grune (Friedrich Schiller University Jena, Germany) |
7:30 pm - 8:00 pm | Ashley Bush (University of Melbourne) "Beta-amyloid metal interactions in Alzheimer’s disease: physiological and pathological" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Andrea Hunt (University of Guelph) "Cell cycle stage influences premature stress-induced cellular senescence" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Swati Joshi-Barve (University of Louisville) "Acrolein-Induced Hepatotoxicity: Role of Oxidative Stress, Mitochondrial Dysfunction and Endoplasmic Reticulum Stress" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Dario Ramirez (Experimental Therapeutics - OMRF) "Myeloperoxidase and oxida-tion of adipose tissue in obesity" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Jan Riemer (University of Kaiserslautern) "Mia40-dependent oxidation of cysteines in the copper chaperone of Sod1 (Ccs1) control its distribution between mitochondria and cytosol" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation, oxidative stress, and cardiovascular disease |
9:00 am - 9:15 am | Discussion Leader: Joseph Witztum (University of California, San Diego, CA) |
9:15 am - 9:45 am | Ming-Hui Zou (University of Oklahoma, OK) "Redox regulation of endothelial cell phenotypes" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Jean Schaffer (Washington University, MO) "Unexpected regulators of metabolic stress" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Michael Sacks (NIH) "A Novel Acetyltransferase Counterregulates SIRT3 Control of Mitochondrial
Respiration" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | General Discussions (sessions #7 and #8) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Complications of diabetes and oxidative stress |
7:30 pm - 7:45 pm | Discussion Leader: Angelika Bierhaus (Heidelberg) |
7:45 pm - 8:10 pm | Sam El-Osta (Baker IDI Hert and Diabetes Institute, Melbourne) "Mapping glucose-induced epigenomic signatures" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Geoffery Gurtner (Stanford University, CA) "Diabetes Induced Defects in Mesenchymal Stem Cell Recruitment and Function" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Erwin Bottinger (Mt Sinai, NY) "Oxidative stress and mitochondrial dysfunction in diabetic nephropathy" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |