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Oxidative Stress and Disease

Gordon Research Conference

Redox Biology in Disease and Translational Medicine

March 19 - 24, 2017
Chairs and
Vice Chairs and
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

The theme for 2017 Oxidative Stress and Disease GRC is "Redox Biology in Disease and Translational Medicine". Its focus is on questions and approaches at the forefront of the field of redox biology with particular emphasis on cutting edge basic research with high translational potential to eliminate disease, improve quality of life and promote healthy longevity. A special effort has been made to highlight important research areas not recently emphasized at other meetings. Topics of emphasis at the 2017 meeting will include: (1) recent insights into ROS/RNS signaling and its translational potential, (2) advances in our understanding of proteostasis and mitochondrial quality in longevity, (3) the role of ROS/RNS in human health, inflammation and disease progression, and (4) initial strategies currently being applied for translation of basic redox biology research discoveries into the clinical realm.

Related Meeting

This GRC will be held in conjunction with the "Oxidative Stress and Disease" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Redox Language in Medical Research
Discussion Leader:
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Interplay of Oxygen Radicals, Nitric Oxide and Redox-Active Compounds: Relevance to Human Physiology, Disease and Aging"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"NOX, NOS and sGC as Therapeutic Targets Within a Cluster of Redox-Related Diseases"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteostasis, Autophagy and Longevity
Discussion Leader:
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Proteostasis in Aging and Disease"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Selective Autophagy in the Fight Against Age-Related Disease"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Selected from Poster Abstracts:
"Nox2 ROS: Putting a Break on Autophagy"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts:
"TRIM21 as a Negative Regulator of the p62-Keap1-Nrf2 Pathway"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Introduction by Discussion Leader
11:50 am - 12:05 pm
Selected from Poster Abstracts:
"Differentiation Impairs Bach1 Dependent HO-1 Activation and Increases Sensitivity to Oxidative Stress in Neuroblastoma Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Selected from Poster Abstracts:
"Dynamics of SOD3 Secretion by Stimulated Macrophages"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: and
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Revisiting: The Cross-Talk Between ROS Signaling and Cell Homeostasis
Discussion Leader:
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Mitochondrial Stress Signaling in Disease and Immunity"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
"Regulation of Cell Signaling by Lipid Oxidation Products and Antioxidants"
7:15 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Redox Regulation of Proteostasis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
ROS/RNS in Vascular Aging
Discussion Leader:
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Angiogenesis and Oxidized Lipids in Atherosclerosis"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Vascular Aging in the Brain"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Intra and Extracellular Thiol Isomerases in Disease-Associated Vascular Remodeling"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts:
"The Role of Mitochondrial Reactive Oxygen Species in the Response of the Pulmonary Vasculature to Hypoxia and Right Heart Remodeling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts:
"Paraoxonase-1 Inactivation by Oxidative Stress in Cardiovascular Disease"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mitochondrial Quality and Control in the Diseased Brain
Discussion Leader:
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Decoding Alzheimer-Like Neurodegeneration from Mitochondrial Defects"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
"Mitochondrial Fe-S Cluster Dysfunction in Neurodegenerative Disease"
7:15 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Selected from Poster Abstracts:
"Novel Mechanisms Involving Redox Biology Are Essential to Support Axonal Growth"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Challenges: Inflammation and Diseases of the Gut, Lung, Pancreas, Liver
Discussion Leader:
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Dietary Flavonoids in the Treatment of the Inflamed and Leaky Gut"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Mitochondrial Iron Metabolism in COPD"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"ROS in Liver Disease and Type2 Diabetes"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts:
"ROS in Chronic Lung Diseases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts:
"Endoplasmic Reticulum Stress-Related Signaling and Lipid Metabolism in Non-Alcoholic Fatty Liver Disease"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Redox Reactions in Infectious Diseases
Discussion Leader:
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"The Broad Antiviral Effect of Oxysterols: Molecular Aspects and Therapeutic Potential"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
"A Radical Virus Needs Radical Strategies – HCV-Induced Oxidative Stress in Viral Biology and Disease"
7:15 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Selected from Poster Abstracts:
"2-Deoxyglucose and Bisphosphonate Show Common Pathways in Its Drug Repurposed Anticancer and Anti-Infection Actions"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Redox-Orientated Biotechnology and Medicine
Discussion Leader:
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Engineering Exosomes to Deliver a Potent Redox Enzyme Catalase to the Brain"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Therapeutic Implications of Mitochondrial Redox Impairment in Human Disease and Aging"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Modulation of Oxidative Stress Response in Neurodevelopment Disorders. The Case of the Rett Syndrome Variants: MECP2 and CDKL5"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts:
"Targeted Lipidomic Analysis of Oxysterols in Plasma from Patients with Alzheimer's Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts:
"Lipid Peroxidation Product Ethylene Is a Real-Time Respiratory Marker for Systemic Inflammation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Mechanisms Underlying Oxidative Stress and Exercise
Discussion Leader:
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Modulation of ROS Levels as a Strategy to Improve Healthy Aging: The Exercise Model"
6:35 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
"Neuromuscular Defects as a Regulator of Oxidative Stress in Aging Skeletal Muscle"
7:15 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
Selected from Poster Abstracts:
"Phenotypic Assessment of Lymphocyte Thiol Reduction Following Acute Exercise: Characterisation of a Highly Reduced CD8+ T Cell Population"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure

Contributors

Conference Links

Conference History Oxidative Stress and Disease (GRS)
Additional Fee Info

Biology of Aging
August 3 - 8, 2025
Lipidomics
March 15 - 20, 2026
Stress Proteins in Growth, Development and Disease
July 6 - 11, 2025
Systems Aging
June 14 - 19, 2026


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