| SATURDAY |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Aging Brain in Motion: An Imaging Strategy for Disease Diagnosis and Monitoring |
| Discussion Leader: Enrique Cadenas (University of Southern California, USA) |
| 3:15 pm - 3:50 pm | Agneta Nordberg (Karolinska Institute, Sweden)
"Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease"
|
| 3:50 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session I |
| 5:30 pm - 7:30 pm | Common Mechanisms Underlying Brain Aging and Neurodegeneration |
| Discussion Leader: Roberta Diaz Brinton (University of Southern California, USA) |
| 5:30 pm - 5:50 pm | Ana Ledo (Universidade de Coimbra, Portugal)
"Oxygen and nitric oxide concentration profiles linked to NMDA receptor activity in the hippocampus of a model of Alzheimer's disease"
|
| 5:50 pm - 5:55 pm | Discussion |
| 5:55 pm - 6:15 pm | Dimitrije Krstic (University of Zurich)
"Degenerating neurites as cause of Aß accumulation and amyloid plaque formation"
|
| 6:15 pm - 6:20 pm | Discussion |
| 6:20 pm - 6:40 pm | Gabriella Leonarduzzi (University of Turin, Italy)
"Interaction between lipid oxidation products and amyloid-β in amplifying neuronal damage in Alzheimer's disease"
|
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 7:05 pm | Lauren Klosinski (University of Southern California, USA)
"Mechanistic link between mitochondrial dysfunction and white matter degeneration in the normal mammalian aging female brain: Proof of concept"
|
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Arvind Goswami (Indian Institute of Science, India)
"Understanding the contribution of variants of mtHsp70 leading to mitochondrial dysfunction in Parkinson's disease"
|
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Prevention and Treatment for Brain Aging and Neurodegeneration: Translational Approaches |
| Discussion Leader: Agneta Nordberg (Karolinska Institute, Sweden |
| 9:00 am - 9:20 am | Tianyi Jiang (University of Southern California)
"Lipoic Acid Restores Age-Associated Impairment of Brain Energy Metabolism"
|
| 9:20 am - 9:25 am | Discussion |
| 9:25 am - 9:45 am | Harsh Sancheti (University of Southern California)
"Lipoic Acid as a Therapeutic/Nutraceutical Agent in Alzheimer's Disease"
|
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:10 am | Natalie Noe (Institute for Genetics, Germany)
"Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy"
|
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Jamaica Rettberg (University of Southern California, USA)
"Development of metabolic and physiological biomarker profiles for early detection of women at risk for Alzheimer's disease"
|
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Catia Lourenco (Universidade de Coimbra, Portugal)
"Neuronal-nitric oxide dynamics and coupled neurovascular coupling in Alzheimer Disease and Aging" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Career Development |
| Discussion Leaders: Jia Yao (University of Southern California, USA) and Fei Yin (University of Southern California, USA) |
| 1:30 pm - 2:15 pm | Ladora Thompson (University of Minnesota, USA)
"Negotiating The First Academic Position & Identifying Career Development Applications for Success"
|
| 2:15 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
