| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | OXIDATIVE STRESS AND ATHEROSCLEROSIS |
| Discussion Leader: Balz Frei, Oregon State University |
| 7:30 pm - 8:10 pm | Bill Sessa - Yale University
"Control of eNOS and the Inflammatory Response" |
| 8:10 pm - 8:50 pm | Nobuyo Maeda - University of North Carolina
"Environmental estrogens and atherosclerosis - insights from genetic models" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MECHANISMS OF CELL SIGNALING; ENZYMATIC AND NON-SPECIFIC LIPID PEROXIDATION |
| 9:00 am - 9:10 am | Announcements and Chair's Introductory Remarks |
| Discussion Leaders: Larry Marnett, Vanderbilt University
Kevin Moore, University of London |
| 9:10 am - 9:50 am | Jason Morrow - Vanderbilt University
"The Isoprostanes: Non-enzymatic oxidation products of arachadonic acid as biomarkers and mediators of environmental toxicology and disease" |
| 9:50 am - 10:30 am | Koji Uchida - Nagoya University, Japan
"Redox proteomics - Identification of molecular targets of electrophilic oxidized lipids" |
| 10:30 am - 11:05 am | Coffee Break / Group Photo |
| 11:05 am - 11:45 am | Valerie O'Donnell - University of Wales College of Medicine
"Regulation of NO bioavailability by lipoxygenase and prostaglandin H synthase in vascular cells" |
| 11:45 am - 12:30 pm | John A. Bauer - Columbus Children's Research Inst., Ohio State Univ.
"Reactive nitrogen species and cardiac dysfunction" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session - One |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THIOL-DEPENDENT CONTROL OF OXIDATIVE REACTIONS IN RESPONSE TO STRESS |
| Discussion Leader: Peter Wardman, Gray Cancer Institute, UK |
| 7:30 pm - 8:10 pm | Leslie Poole - Wake Forest University
"Structural evolution linked to redox signaling functions of peroxiredoxins and sulfenic acids" |
| 8:10 pm - 8:50 pm | Claudette St. Croix - University of Pittsburgh, PA
"Mechanisms of protection against oxidative injury : Metallothionein, nitric oxide and the regulation of metal ion homeostasis" |
| 8:50 pm - 9:20 pm | Roderick Capaldi - University of Oregon
"Focused Proteomics; immunocapture separation of the OXPHOS complexes and analysis of oxidative damage"
|
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENVIRONMENTAL RISK FACTORS AND HUMAN DISEASE |
| Discussion Leaders: Koji Uchida, Nagoya Univ., Japan
Manisha Patel, Univ. Colorado
|
| 9:00 am - 9:40 am | Vince Castranova - NIOSH, Morgantown, W.V.
"Signaling stimulated by environmental particle inhalation" |
| 9:40 am - 10:10 am | Tim Dalton - University of Cincinnati, Ohio
"Development of models to assess the role of glutathione in protection against environmental stress" |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:20 am | Susan Thorpe - University of South Carolina
"Lipoxidation and diabetic complications" |
| 11:20 am - 12:00 pm | Julie Andersen - Buck Institute for Age Research, Novato, CA
"Iron and Parkinson's disease" |
| 12:00 pm - 12:30 pm | Stan Hazen - Cleveland Clinic
"Update on MPO and cardiovascular disease pathogenesis"
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session - One |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CLINICAL ASPECTS OF REACTIVE OXYGEN AND NITROGEN SPECIES IN BIOLOGY |
| Discussion Leaders: Raman Kalyanaraman, Medical College of Wisconsin |
| 7:30 pm - 8:10 pm | Serpil Ezurum - Cleveland Clinic, Ohio
"Interaction of reactive nitrogen species in human lung disease; insights from pulmonary hypertension and asthma" |
| 8:10 pm - 8:50 pm | Kevin Moore - University of London, UK
"Clinical Aspects and Reactive Nitrogen species in the vasculature" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | OXIDANT AND ANTIOXIDANT ACTIONS IN BIOLOGY |
| Discussion Leaders: Rafael Radi, Univ. of the Republic, Montevideo
Matthew Grisham, LSU Health Sciences Center, LA |
| 9:00 am - 9:40 am | Vladimir R. Muzykantov - Univ. of Pennsylvania School Of Medicine
"Immunotargeting of antioxidants to pulmonary endothelium" |
| 9:40 am - 10:10 am | David Golde - Memorial Sloan-Kettering Cancer Ctr.
"Vitamin C in Cell Signaling and Genomic Protection" |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:10 am | Ines Batinic-Harbele - Duke University
"Manganese porphyrins as catalytic antioxidants" |
| 11:10 am - 11:50 am | Santiago Lamas - Centro de Investigaciones Biologicas, Madrid, Spain
"The role of oxidative and nitrosative stress in the modification of protein function: studies on transcription factors and endothelial cells" |
| 11:50 am - 12:30 pm | Erica Werner - Emory University, Atlanta
"Integrins engage mitochondrial function for signal transduction and
gene-expression: role of Reactive Oxygen Species" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session - Two |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REDOX CELL SIGNALING |
| Discussion Leader: Henry Forman, University of Alabama at Birmingham |
| 7:30 pm - 8:10 pm | Hanjoong Jo - Emory University, GA
"Superoxide produced from NADPH oxidase by oscillating shear induces endothelial inflammation, an early atherogenic marker" |
| 8:10 pm - 8:50 pm | J. Andres Melendez - Albany Medical College
"Modulation of the mitochondrial redox environment and signal transduction" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| 9:00 am - 12:30 pm | OXIDATIVE STRESS IN THE CENTRAL NERVOUS SYSTEM |
| Discussion Leaders: Joseph Beckman, Oregon State University
Valerie O'Donnell, Univ. Wales, Col. Medicine
|
| 9:00 am - 9:10 am | Introductory Remarks |
| 9:10 am - 9:50 am | Teresa Hastings - University of Pittsburgh School of Medicine
"Dopamine oxidation and dopamine protein adducts in neurodegenerative diseases" |
| 9:50 am - 10:30 am | Tim Greenmayre - Emory University, GA
"Inhibition of Complex 1 and Parkinson's Disease by exposure to rotenone" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:40 am | Walter D. Longo - University of Southern California
"Aging and stress resistance - the role of superoxide" |
| 11:40 am - 12:10 pm | Manisha Patel - Univ. of Colorado Health Sciences Center, Denver, CO
"Oxidative stress and mitochondrial dysfunction in epilepsy" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session - Two |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE LECTURE |
| 7:30 pm - 8:30 pm | Bruce A. Freeman - University of Alabama at Birmingham
"Nitrated Lipids - Clinical Detection and Cell Signaling Properties" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
