SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:15 pm | SUPEROXIDE DISMUTASE (SOD) |
| Discussion Leader: John Keaney |
7:40 pm - 8:10 pm | Joe Beckman (Oregon State University) "SOD as a new twist in the dark side of Nitric Oxide" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Serpil Erzurum (Cleveland Clinic) "Oxidative and Nitrosative Events in Asthma" |
9:00 pm - 9:15 pm | Discussion |
9:30 pm - 11:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | OXIDATIVE STRESS, INFLAMMATION AND CARDIOVASCULAR SYSTEM |
| Discussion Leader: Serpil Erzurum |
9:00 am - 9:05 am | Announcements and Chair's Introductory Remarks |
9:05 am - 9:25 am | Cecelia Giulivi (UC Davis)
"Biochemical Impact of Mitochondrial Protein Nitration" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | John Keaney (Boston University School of Medicine) "Mitochondrial Modulation of Endothelial Phenotype" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Arundhati Undurti (Cleveland Clinic)
"Multiple independent oxidation pathways contribute to enhanced oxidative stress in sickle cell disease" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Neil Granger (LSU Health Sciences Center) "Immune cell-mediated Vascular Dysfunction: Role of Reactive Oxygen Species" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Group Photo |
11:30 am - 11:50 am | Clay Semenkovich (Washington University) "Novel Approaches to Diminish the Oxidant Stress of Metabolic Syndrome" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Annie Beuve (New Jersey Medical School)
"Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation: a missing link between oxidative stress and NO/nitrate tolerance" |
12:10 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | OXIDIZED LIPIDS AND DISEASE MECHANISMS |
| Discussion Leader: Valerian Kagan |
7:30 pm - 7:50 pm | Eugene Podrez (Cleveland Clinic) "Oxidized Phospholipids & Atherothrombotic Disease" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Valerie O'Donnell (Cardiff Univ., School of Medicine) "Identification and Characterization of new LOX Products in Immune cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Jooyeun Oh (University of Alabama at Birmingham)
"Cellular responses mediated by the cyclopentenone 15-deoxyprostaglandin J2; a new model for signal transduction by reactive lipids" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | David Ford (Saint Louis University School of Medicine) "Plasmalogen-derived chlorinated lipids in cardiovascular disease" |
8:55 pm - 9:00 pm | Discussion |
9:30 pm - 11:30 pm | Reception |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NO / NITRITE BIOCHEMISTRY AND DISEASE |
9:00 am - 9:05 am | Announcements and Chair's Introductory Remarks |
9:05 am - 9:25 am | Mark Gladwin (National Institutes of Health) "Nitrite Chemistry and Nitrite Signaling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Andrew Gow (Rutgers) "Mechanisms of S-nitrosothiol formation, signaling and decay: Anesidora or Pandora's Box" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Jason Allen (Duke University Medical Center)
"Plasma Nitrite and Arterial Reactivity Differentiate Cardiovascular Health Status and Performance" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Jon Lundberg (Karolinska, Sweden) "Dietary Nitrate in Health and Disease" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Rakesh Patel (Univ. of Alabama at Birmingham) "Nitrite versus SNO-hemoglobin in the Regulation of Vascular Tone" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Katherine Wood (National Institute of Health)
"Circulating Blood Cell Versus Vascular Endothelial Cell Contributions to Intravascular Nitrite Concentrations and Blood Pressure Regulations" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | IRON PROTEINS AND OXIDATIVE STRESS |
| Discussion Leader: Valerie O’Donnell |
7:30 pm - 7:50 pm | Raman Kalyanaraman (Medical College of Wisconsin) "Mito-Q attenuates cardiotoxicity and enhances breast cancer cell toxicity induced by doxorubicin: Mechanistic considerations" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Paul Fox (Cleveland Clinic) "Iron & Copper: The History of a Metabolic Couple" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Ron Mason (NIEHS/NIH)
"Procainamide, but not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Zeneng Wang (Cleveland Clinic)
"Peroxidase catalyzed thiocyanate oxidation contributes to smoking induced asthma exacerbation" |
8:55 pm - 9:00 pm | Discussion |
9:30 pm - 11:30 pm | Reception |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CHEMISTRY OF THIOLS & THIOL SIGNALING |
| Discussion Leader: Raman Kalyanaraman |
9:00 am - 9:05 am | Announcements and Chair's Introductory Remarks |
9:05 am - 9:25 am | Neil Hogg (Medical College of Wisconsin) "The ABC’s of Thiol Chemistry" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Richard Cohen (Boston University)
"S-Glutathiolation and Cell Signaling" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Lars Leichert (University of Michigan)
"Quantifying ROS Induced Thiol Modifications" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Michael Murphy (Cambridge University)
"Development of a mitchondria-targeted S-nitroso-thiol reagent" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | David Kraus "Hydrogen Sulfide and cell signaling" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Dario Vitturi (University of Alabama at Birmingham)
"Role of Hemoglobin Beta93 Cysteine in Red Cell Metabolsim of Hydrogen Peroxide" |
12:05 pm - 12:10 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:00 pm | DIABETES & OXIDATIVE STRESS |
| Discussion Leader: Clay Semenkovich |
7:30 pm - 8:00 pm | Michael Brownlee (Albert Einstein College of Medicine) "ROS and the Pathogenesis of Diabetic Complications" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | David Stern (University of Cincinnati) "RAGE’s (Receptors for Advanced Glycation End Products)" |
8:45 pm - 9:00 pm | Discussion |
9:30 pm - 11:30 pm | Reception |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MITOCHONDRIA & FREE RADICAL GENERATION |
| Discussion Leader: Cecelia Giulivi |
9:00 am - 9:05 am | Announcements and Chair's Introductory remarks |
9:05 am - 9:25 am | Victor Darley-Usmar (Univ. of Alabama at Birmingham) "Lipids and Mitochondrial Signaling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Robert Balaban (NIH) "Mitochondrial Proteomics" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:15 am | Michael Ristow (University of Jena) "Glucose restriction extends caenorhabditis elegans life span by increasing oxidative stress" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Valerian Kagan (University of Pittsburgh) "Apoptotic Redox Switch in Mitochondria: Gluing Cytochrome c to Cardiolipin" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Shruti Shiva (NIH) "Mitochondria, Nitrite and Ischemia Reperfusion Injury" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Leandra-Louise Bowers (University of Leicester)
"High glucose induces mitochondrial ROS and accelerates human endothelial cell ageing" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Futoshi Okada (Yamagata University)
"Inflammation and its-derived reactive oxygen species as an endogenous factor in tumor development and progression" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:40 pm | OXIDATIVE CHEMISTRY & DISEASE PROCESSES |
| Discussion Leader: Joe Beckman |
7:30 pm - 8:15 pm | Keynote Lecture: Joe Loscalzo (Brigham and Women’s Hospital) "Oxidative Enzymopathies and Vascular Disease" |
8:15 pm - 8:40 pm | Discussion |
9:30 pm - 11:30 pm | Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |