SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leaders: Ronald Mason (NIEHS/NIH, USA) and Alicia Kowaltowski (Universidade de Sao Paulo, Brazil) |
7:40 pm - 8:40 pm | Salvador Moncada (University College London, UK)
"Connecting Cell Cycle Progression to Metabolic Requirements"
|
8:40 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
9:30 pm - 11:00 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Detection Methods: New and Improved |
9:00 am - 9:05 am | Discussion Leader: Jacek Zielonka (Medical College of Wisconsin, USA)
"Announcements" |
9:05 am - 9:25 am | Rheal Towner (Oklahoma Medical Research Foundation, USA)
"In Vivo Assessment of Radical Adducts in Various Diseases Involving Oxidative Stress-Induced Pathologies"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Periannan Kuppusamy (Dartmouth College, USA)
"'Sense & Sensibility' of Oxygen in Myocardial Infarction and Therapy"
|
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Hal Swartz (Dartmouth University, USA)
"Using Radiation-Induced Free Radicals as In Vivo Dosimeters After Unplanned Exposures to Ionizing Radiation"
|
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Miklos Geiszt (Semelweiss University, Budapest, Hungary)
"Reactive Oxygen Species in Extracellular Matrix Formation"
|
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Paolo Di Mascio (São Paulo University)
"Singlet Molecular Oxygen Generated in the Dark"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Radoslaw Michalski (Lodz University of Technology)
"The Application of Profluorescent Boronate Probes for the Detection of Protein Hydroperoxides" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein Oxidative Modification and Turnover |
| Discussion Leaders: Marilene Demasi (Butantan Institute, Brazil) and Ursula Jakob (University of Michigan, USA) |
7:30 pm - 7:50 pm | Ned Porter (Vanderbilt University, USA)
"Free Radicals, Oxygen and Sterol Biosynthesis Disorders"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Marilene Demasi (Butantan Institute, Brazil)
"Redox Regulation of the Proteasomal Catalytic Unit"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ursula Jakob (University of Michigan, USA)
"Redox-Regulation of Molecular Chaperones" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Lars Leichert (Ruhr-Universitat Bochum)
"HOCl Activates Chaperone Function by N-Chlorination" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Mitochondria: Redox Organelles |
9:00 am - 9:05 am | Discussion Leader: John J. Lemasters (Medical University of South Carolina)
"Announcements" |
9:05 am - 9:25 am | Janine Santos (New Jersey Medical School, USA)
"The Role of ATM in the Repair of Oxidative Lesions to Mitochondrial DNA"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Orian Shirihai (Boston University, USA)
"ABCB10, a Novel Player in Mitochondrial ROS Management in the Heart, Islet and Blood" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Kostas Tokatlidis (University of Crete, Greece)
"The Mitochondrial Intermembrane Space: Redox Regulation of Protein Biogenesis"
|
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Marcelo Bonini (University of Illinois, USA)
"MnSOD Upregulation in Cancer Enables Mitochondria to Signal AMPK: Implications for the Warburg Effect"
|
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Roberta Gottlieb (San Diego State University, USA)
"Mitophagy as a Key Feature of ROS Control"
|
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Yeong-Renn Chen (Northeast Ohio Medical University)
"Oxidant Stress-Induced Protein Thiyl Radical Mediates Enhanced S-Glutathionylation of Complex I in the Murine Heart of eNOS-/-" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Free Radicals in Carcinogenesis |
| Discussion Leader: Maria Kadiiska (National Institute of Environmental Health Sciences, USA) |
7:30 pm - 7:50 pm | Erik Tokar (National Institute of Environmental Health Sciences, USA)
"Oxidative DNA Damage in Arsenical Carcinogenesis"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Valerian Kagan (University of Pittsburg, USA)
"ROS and Oxidative Lipidomics of Apoptotic Signaling"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Marisa H. G. Medeiros (University of São Paulo, Brazil)
"Aldehyde-DNA Adducts as Biomarkers of Urban Air Pollution Exposure"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Aimee Landar (University of Alabama at Birmingham)
"Metabolic Reprogramming of Cancer Cells by a Novel Class of Anti-Cancer Agents:
Mitochondrially-Targeted Electrophiles (MTEs)"
|
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Oxidative Modifications in Aging and Age-Related Disease |
9:00 am - 9:05 am | Discussion Leader: Kelvin J. A. Davies (University of Southern California, USA)
"Introduction" |
9:05 am - 9:25 am | Paul Schumacker (Northwestern University, USA)
"Mitochondrial Redox Signals Regulate Cell Stress Responses"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Juan Bolaños (University of Salamanca, Spain)
"Bioenergetic and Antioxidant Defense Coupling in the Nervous System"
|
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Holly Van Remmen (Oklahoma Medical Research Foundation, USA)
"Contribution of Pre- and Postsynaptic Oxidative Stress in Age-Related Skeletal Muscle Atrophy"
|
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Etsuo Niki (National Institute of Advanced Industrial Science & Technology, Health Research Institute, Ikeda, Osaka, Japan)
"Free Radicals and Antioxidants as Double Edged Swords"
|
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Ohara Augusto (University of São Paulo, Brazil)
"Oxidative Mechanisms in Protein Aggregation"
|
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | David Marcinek (University of Washington Medical School)
"Targeting Mitochondrial Free Radical Production to Improve Skeletal Muscle Function in Aged Mice" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Rates Do Matter |
| Discussion Leader: Michael Davies (University of Sydney, Australia) |
7:30 pm - 7:50 pm | Wim Koppenol (Swiss Federal Institute of Technology, Switzerland)
"Protein Oxidation, Intramolecular Electron Transfer, and Repair"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Michael Strano (Massachusetts Institute of Technology, USA)
"Single Molecule Detection of Reactive Oxygen and Nitrogen Species Using Single Walled Carbon Nanotube Fluorescent Sensors"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Gerardo Ferrer-Sueta (Universidade de la Republica, Uruguay)
"Reactions of Thiols with Peroxides, a Kinetics Perspective"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Beijing Huang (Massachusetts Institute of Technology)
"A Platform for Intracellular Quantification and Generation of Reactive Oxygen Species in Mammalian System" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:55 am | Free Radical Metabolites in the Initiation of Autoimmunity |
9:00 am - 9:05 am | Discussion Leader: Fred Miller (National Institute of Environmental Health Sciences, USA)
"Announcements" |
9:05 am - 9:25 am | R. Hal Scofield (University of Oklahoma Health Sciences Center, USA)
"Free Radical Damage in Systemic Lupus Erythematosus and Sjogren's Syndrome"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Arno Siraki (University of Alberta, Canada)
"The Role of Neutrophil Myeloperoxidase Drug Oxidation in the Development of Autoimmunogens"
|
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Joesph L. Witzum (University of California, San Diego, USA)
"Role of Oxidized Phospholipids in Inflammation and Atherosclerosis"
|
10:25 am - 10:35 am | Discussion |
10:35 am - 10:55 am | Coffee Break |
10:55 am - 12:30 pm | A New Look at Dinitrosyl Iron Complexes in Cancer |
| Discussion Leader: Paul Winyard (University of Exeter Medical School) |
10:55 am - 11:15 am | Neil Hogg (Medical College of Wisconsin, USA)
"NO/Iron Interactions and the Control of Cancer Cell Bioenergetics"
|
11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Jack Lancaster (University of Alabama, USA)
"Dinitrosyliron Complexes: What We May Finally Know About the Cellular Functions of a Tumor Biomarker First Described 50 Years Ago?"
|
11:45 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Doug Thomas (University of Illinois at Chicago, USA)
"Epigenetic Mechanisms of DNIC in Cancer Etiology"
|
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Gerardo Ferrer-Sueta (Universidade de la Republica, Uruguay) |
7:30 pm - 8:30 pm | Sue Goo Rhee (Ewha Women's University, S. Korea)
"Concerted Action of Peroxiredoxin III and Sulfiredoxin Controls Mitochondrial H2O2 Release"
|
8:30 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |