Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Sleep Apnea, Oxygen Radicals and Hypertension |
| Discussion Leader: Rakesh Patel (University of Alabama at Birmingham, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:40 pm | Gregg Semenza (Johns Hopkins University, USA) "Sleep Apnea, Oxygen Radicals and Hypertension" |
8:40 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pathophysiologic Roles of Oxidized Lipids |
| Discussion Leaders: Henry Jay Forman (University of Southern California, USA) and Homero Rubbo (University of the Republic, Uruguay) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Bruce Freeman (University of Pittsburgh, USA) "Anti-Inflammatory Electrophilic Fatty Acid Species" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | David Ford (Saint Louis University School of Medicine, USA) "Chlorinated Fatty Acids and ROS" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Anna-Liisa Levonen (University of Eastern Finland, Finland) "Activation of Stress Signaling Pathways by Electrophilic Lipids" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Valerie O'Donnell (Cardiff University, United Kingdom) "Mapping the Platelet Oxy-Lipidome" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Chris Cooper (University of Essex, United Kingdom) "Artificial Blood: Engineering a Haemoglobin Based Oxygen Carrier with Decreased Lipid Peroxidation Activity" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Witold Korytowski (Medical College of Wisconsin, USA) "Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking; Implications for Atherogemesis Under Oxidative Stress" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Manisha Patel (University of Colorado, Anschutz Medical Campus, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Sirtuins, Aging and Redox |
| Discussion Leaders: Rick Domann (University of Iowa, USA) and Sruti Shiva (University of Pittsburgh, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:45 pm | Selected from Poster Abstracts: Lindsey Gano (University of Colorado Anschutz Medical Campus, USA) "SIRT3 Dysfunction in Experimental Temporal Lobe Epilepsy" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:10 pm | Raul Mostoslavsky (Massachusetts General Hospital, Harvard Medical School, USA) "Sirtuins in Regulation of Redox Status" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Carlos Escande (Institut Pasteur de Montevideo, Uruguay) "Role of the Protein DBC1 in the Regulation of Obesity and Aging" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Paul Brookes (University of Rochester Medical Center, USA) "Sirtuins and Mitochondrial Redox" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Paradigms in Redox Signaling |
| Discussion Leaders: Victor Darley-Usmar (University of Alabama at Birmingham, USA) and Douglas Thomas (University of Illinois at Chicago, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Raj Soorappan (University of Alabama at Birmingham, USA) "Reductive Stress and Proteotoxicity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Tobias Dick (German Cancer Research Center, Germany) "Thiol Peroxidase Based Redox Relays" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Yvonne Hanssen Heininger (University of Vermont, USA) "Glutaredoxin and S-Glutathionylation Dependent Redox Signaling" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Daniela Salvemini (St. Louis University, USA) "Free Radicals and Pain Sensing" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Joris Messens (VIB, Vrije Universiteit Brussel, Belgium) "Promiscuity in Thiol Redox Control" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Shireen Attaran (University of Pittsburgh, USA) "Prdx1 Inhibits Breast Cancer Progression Through Inhibiting the Activated Phenotype of Mammary Stroma-Associated Fibroblasts" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Detection Methods and Probes for Reactive Species |
| Discussion Leaders: Paul Winyard (University of Exeter Medical School, United Kingdom) and Jacek Zielonka (Medical College of Wisconsin, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Vinayak Gupta (The Scripps Research Institute - Florida, USA) "Tag-Switch Methods for Thiols and Sulfide Measurement" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Dan Yang (The University of Hong Kong, Hong Kong SAR China) "Fluorescent Probe Based Detection of Free Radicals in Biological Systems" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Cristina Furdui (Wake Forest School of Medicine, USA) "Chemical Approaches to Investigate Thiol-Based Redox Regulation in Biological Systems" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Ashutosh Kumar (National Institute of Environmental Health Sciences, NIH, USA) "Immuno-Spin Trapping of Alpha-Synuclein Radical Formed in Maneb and Paraquat Induced Model of Parkinson's Disease" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Oxygen Radicals and Mechanisms of Disease |
| Discussion Leader: Victor Thannickal (University of Alabama at Birmingham, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Karen Bernard (University of Alabama at Birmingham, USA) "Mitochondrial ROS and Lung Fibrosis" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Carola Neumann (Magee-Womens Research Institute, USA) "The Role of Prx-1 in Cancer Signaling" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Francisco Laurindo (Heart Institute of the University of São Paulo, Brazil) "Pathophysiology of NOX in Cardiovascular Disease" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Douglas Spitz (University of Iowa, USA) "ROS and Cancer" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Manisha Patel (University of Colorado, Anschutz Medical Campus, USA) "Mitochondrial ROS and Neuronal Disorders" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Clare Hawkins (Heart Research Institute, Australia) "Role of the Myeloperoxidase Oxidant Hypothiocyanous Acid (HOSCN) in Redox Perturbation and Cellular Dysfunction" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Infectious Diseases and Free Radicals |
| Discussion Leaders: Michael Davies (University of Copenhagen, Denmark) and Christine Winterbourn (University of Otago Christchurch, New Zealand) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:45 pm | Selected from Poster Abstracts: Lin Mantell (North Shore University Hospital, St. John's University, USA) "The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance by Restoring Hyperoxia-Compromised Macrophage Function" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:10 pm | Jon Lundberg (Karolinska Institutet, Sweden) "Gut Microbiota and Nitrogen Oxide Signaling" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Michelle Reniere (University of Washington, USA) "Glutathione and Pathogen Virulence" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Lars Dietrich (Columbia University, USA) "Redox Regulation of Biofilm Development in Pseudomonas aeruginosa" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Role for CO and H2S in Oxygen Radicals Biology |
| Discussion Leaders: Neil Hogg (Medical College of Wisconsin, USA) and Jon Lundberg (Karolinska Institutet, Sweden) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Beatriz Alvarez (University of the Republic, Uruguay) "Reactivity of Hydrogen Sulfide with Oxidants" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Wayne Orr (LSU Health Sciences Center Shreveport, USA) "H2S and ROS Signaling" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Takaaki Akaike (Tohoku University Graduate School of Medicine, Japan) "Polysulfides and Redox Signaling" |
10:25 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Roland Stocker (Victor Chang Cardiac Research Institute, Australia) "Novel Insights into Tryptophan Oxidation Mediated by Indoleamine 2,3-Dioxygenase and Its Role in Arterial Relaxation" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Roberto Motterlini (INSERM U955 / Université Paris-Est, France) "CO-Releasing Molecules and Redox Signaling" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Bindu Paul (Johns Hopkins University School of Medicine, USA) "The Intersection Between H2S and Superoxide Signaling in Amyotrophic Lateral Sclerosis" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Mitochondrially Targeted Antioxidants and Signaling |
| Discussion Leader: Ana Denicola (University of the Republic, Uruguay) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:30 pm | Michael Murphy (MRC Mitochondrial Biology Unit, United Kingdom) "Mitochondrially Targeted Antioxidants and Signaling" |
8:30 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | General Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |