Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Quantitative Analyses of Redox Changes
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:40 pm
"Quantitative Analyses of Redox and Electrophile Reactive Thiol Proteomes"
8:40 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria and Oxidant Signaling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Site-Specific ROS Signalling in Health and Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Mitochondrial-Nuclear Genetic Interaction as a Mechanism for Modulating Metabolism and Gene Expression"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice"
10:20 am - 10:25 am
Discussion
10:25 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Platelet Mitochondrial ROS Signaling: To Clot or Not"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Nitric Oxide, Metabolism and Mitochondria Cross Talk"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Myoglobin Regulates the Function of the E3 Ligase Parkin to Modulate Mitochondrial Fusion and Decrease Breast Cancer Tumor Progression"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Roles of Oxygen Radicals in Cancer Etiology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Role of Hypoxia in Mediating Epigenetic Changes in Pediatric Neuroblastoma"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Optochemical-Targeted Mitochondrial Dysfunction Gives Insights into Mitochondria-Nuclear Crosstalk"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Cancer as Iron Addiction with Ferroptosis-Resistance"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Reprogramming Redox Tone and Bioenergetic Health in Cancer by Regulation of Lysosomal Biogenesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Interface Between Nitrogen and Oxygen Radicals
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Following NO in the Progression Cancer: Insight into Mechanism of Poor Outcome"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Modulation of Metabolic Function by Nitrate and Nitrite"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Kinetic and Quantum Mechanical Study on the Decomposition of Piloty's Acid Derivatives Toward the Understanding of Factors Controlling HNO Release"
10:20 am - 10:25 am
Discussion
10:25 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Progress on How Radicals Killed Lou Gehrig (ALS). The Interplay of Copper, SOD, Peroxynitrite and Tyrosine Radicals in Motor Neuron Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"The Chemical Biology of Hydropersulfides: Possible Roles in Redox Signaling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Reactions of Tryptophan Radicals on Peptides and Proteins: Dimersation vs Addition of Superoxide to Give Hydroperoxides"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Altered Redox Signaling Responses to Nanoparticles in Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Peroxiredoxin Involvement in Cellular Redox Signalling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Redox Regulation of Protein Tyrosine Kinases: New Twists and Turns"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"The Pathways for Repair of Peroxidized Cell Membranes"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging, Sensing, and Quantification of Oxidants and Oxidant Damage
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Effects of Developmental ROS on Stress Resistance and Lifespan"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"In Vivo Imaging Biomarkers from EPR Based Techniques to Guide Treatment and Monitor Treatment Response: Pre-Clinical and Clinical Studies"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Hydrogen Peroxide Sensors as Tools to Quantify H2 O2 in Living Systems"
10:20 am - 10:25 am
Discussion
10:25 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Recent Advances in Specific Detection of Superoxide"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Isotope-Reinforced Polyunsaturated Lipids (D-PUFAs), Lipid Peroxidation, and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Ablation of Glutathione-S-Transferase p Attenuates Glycolysis in House Dust Mite-Induced Allergic Airways Disease"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Physiological Responses to Oxidation
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Redox Regulation of Protein Kinase G – Translational Opportunities"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Stress Response Signaling via the Keap1-Nrf2 Pathway"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"The NADPH Oxidase Nox4 as a Key Player in Differentiation"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"To Adapt or Not to Adapt: The Consequences of an Age-Dependent Decline in the Adaptive Homeostatic Response"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Oxygen Radicals, Tissue Damage, and Therapeutics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Myeloperoxidase Contributes to the Destabilisation of Atherosclerotic Plaques"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Imaging Myeloperoxidase Activity"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Convergence of Golgi Stress Response and Cysteine Metabolism Confers Cytoprotection in Huntington's Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Novel Redox Modifications of Proteins: Pathways to Protein Degradation, Aggregation and Immunogenicity"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"The Role of Hypobromous Acid in Tissue Biology"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Unraveling the Mechanism of Selenium Catalysis in GPx4: How Redox Chemistry Impacts on Life from Sperm Function to Embryogenesis and Cell Death"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Redox Paradigm – Where to Now?
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 9:10 pm
"OH NO: NOX, NOS and ROS! Where Do We Go?"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure