Sunday, February 11, 1996

• 02:00 p.m. - 06:00 p.m.: Arrival, Gordon Conference Registration, Doubletree Hotel Check-in
• 06:00 p.m. - 07:30 p.m.: Dinner

Oxygen Radicals & Air Pollution

• 7:30 - 9:30 p.m.: Evening Scientific Session
  • Chairs: William A. Pryor, Ph.D., Louisiana State University, Baton Rouge, LA and Carroll E. Cross, M.D., University of California, Davis, Sacramento, CA
• 07:30 p.m. - 07:45 p.m.
  • Carroll E. Cross, M.D., University of California at Davis, Sacramento, CA - Introduction to Oxygen Radicals & Air Pollution.
• 07:45 p.m. - 08:20 p.m.
  • Henry Jay Forman, Ph.D., University of Southern California, Los Angeles, CA - NO2 - Signaling by an Environmental Hazard.
• 08:20 p.m. - 08:55 p.m.
  • Donald J. Massaro, M.D., Georgetown University School of Medicine, Washington, D.C. - Environmental Oxidants & Lung Cells -the Oxygen Toxicity Model.
• 08:55 p.m. - 09:30 p.m.
  • Kenneth B. Adler, Ph.D., North Carolina State University, Raleigh, NC - Ozone - Signal Transduction and Molecular Responses

Monday, February 12, 1996

Health Benefits of Plant-derived Antioxidants

• 8:45 a.m. - 12:15 p.m.: Morning Scientific Session
  • Chairs: Catherine Rice-Evans, Ph.D., UMDS, University of London, England and Margaret E. Haberland, Ph.D., University of California, Los Angeles, CA
• 08:45 a.m. - 09:00 a.m. - Announcements and Chair's Introductory Remarks
• 09:00 a.m. - 09:45 a.m.
  • Peter M. Bramley, Ph.D., Royal Holloway, University of London, England - Genetic Manipulation of the Carotenoid Synthetic Pathway.
• 09:45 a.m. - 10:30 a.m.
  • Wolfgang Schuch, Ph.D., Zeneca Plant Science, Bracknell, England - Genetic Modification of Tomatoes.
• 10:30 a.m. - 10:45 a.m.: Coffee Break
• 10:45 a.m. - 11:30 a.m.
  • Wolf Bors, Ph.D., Institut Strahlenbiologie, GSF Forschungszentrum, Nueherberg, Germany - Flavonoids: Prooxidants or Antioxidants?
• 11:30 a.m. - 12:15 p.m.
  • David Leake, Ph.D., University of Reading, England - Interactions of Flavonoids with Oxidised LDL: Implications for Atherosclerosis in vivo.
• 12:15 p.m. - 12:30 p.m.: Conference Photograph (outside)
• 12:15 - 7:00 p.m.: Afternoon Activities
• 12:30 p.m. - 01:30 p.m.: Lunch
• 01:30 p.m. - 05:00 p.m.: "ad lib. Scientific Interactions"
• 05:00 p.m. - 06:00 p.m.: Poster Session A (part 1) Chaired by Catherine Rice-Evans, Ph.D.
  • - Oxygen Radicals & Air Pollution
  • - Health Benefits of Plant-derived Antioxidants
  • - Oxygen Radicals & Ageing.
• 06:00 p.m. - 07:00 p.m.: Dinner
• 7:30 p.m. - 9:00 p.m.: Evening Scientific Session
  • Chairs: Catherine Rice-Evans, Ph.D., UMDS, University of London, England and Fulvio Ursini, M..D., University of Udine, Udine, Italy
• 07:30 p.m. - 09:00 p.m.

  DEBATE: 1) Do Carotenoids Act as Antioxidants in vivo?

  DEBATE 2) Are the Flavonoid Constituents of Foods Relevant Antioxidants in vivo?

  • Discussants Include: Lester Packer, Ph.D., University of California, Berkeley, CA and Norman Krinsky, Ph.D., Tufts University Medical School, Boston, MA.

Tuesday, February 13, 1996

Oxygen Radicals & Ageing

• 8:45 a.m. - 12:15 p.m.: Morning Scientific Session
  • Chairs: Huber Warner, Ph.D., National Institute on Aging, Bethesda, MD.and Monique Vuillaume, Ph.D., University of Paris, Paris, France
• 08:45 a.m. - 09:00 a.m.: Announcements and Chair's Introductory Remarks
• 09:00 a.m. - 09:45 a.m.
  • Raj S. Sohal, Ph.D., Southern Methodist University, Dallas, TX - Is Oxidative Stress a Causal Factor in the Aging Process ?
• 09:45 a.m. - 10:30 a.m.
  • Lora E. Rikans, Ph.D., University of Oklahoma, Oklahoma City, OK - Lipid Peroxidation, Antioxidant Protection, and Aging.
• 10:30 a.m. - 10:45 a.m.: Coffee Break
• 10:45 a.m. - 11:30 a.m.
  • Vincent J. Cristofalo, Ph.D., Medical College of Pennsylvania, and Hahnemenn University, Philadelphia, PA - Alterations in Gene Expression Resulting from Oxidative Stress and Aging.
• 11:30 a.m. - 12:15 p.m.
  • Caleb Finch, Ph.D., University of Southern California, Los Angeles, CA - Free Radicals, Oxidative Stress, Brain Aging, and Alzheimers Disease
• 12:15 - 7:00 p.m.: Afternoon Activities
• 12:30 p.m. - 01:30 p.m. Lunch
• 01:30 p.m. - 05:00 p.m. "ad lib. Scientific Interactions"
• 05:00 p.m. - 06:00 p.m. Poster Session A (part 2) Chaired by Catherine Rice-Evans, Ph.D.
  • - Oxygen Radicals & Air Pollution
  • - Health Benefits of Plant-derived Antioxidants
  • - Oxygen Radicals & Ageing.
• 06:00 p.m. - 07:00 p.m. Dinner
• 7:30 p.m. - 9:00 p.m.: Evening Scientific Session
  • Chairs: Joan S. Valentine, Ph.D., University of California, Los Angeles, CA and George T. Baker III, Ph.D., Shock Aging Research Foundation, Silver Springs, MD
• 07:30 p.m. - 08:15 p.m.
  • Charles Epstein, Ph.D., University of California, San Francisco, CA - The Effects of Altered SOD Activity in Aging.
• 08:15 p.m. - 09:00 p.m.
  • Rick Weindruch, Ph.D., University of Wisconsin, Madison, WI - Caloric Intake, Free Radicals and Mitochondrial Aging.

Wednesday, February 14, 1996

Oxygen Radicals, Inflammation, and Ischemia/Reperfusion Injuries

• 8:45 a.m. - 12:15 p.m.: Morning Scientific Session
  • Chairs: Matthew B. Grisham, Ph.D., LSU Medical Center, Shreveport, LA and José Viña, Ph.D., University of Valencia, Valencia, Spain
• 08:45 a.m. - 09:00 a.m.: Announcements and Chair's Introductory Remarks
• 09:00 a.m. - 09:45 a.m.
  • David Wink, Ph.D., DCT/NCI/NIH, Bethesda, MD - Oxidant-induced Cytotoxicity: Modulation by Reactive Metabolites of Oxygen and Nitrogen.
• 09:45 a.m. - 10:30 a.m.
  • Tony Manning, Ph.D., Upjohn Laboratories, Kalamazoo, MI - Role of Oxidants in the NF-cB Mediated Regulation of Inflammation.
• 10:30 a.m. - 10:45 a.m.Coffee Break
• 10:45 a.m. - 11:30 a.m.
  • Paul Kubes, Ph.D., University of Calgary, Alberta, Canada - A Balance Between Nitric Oxide and Oxidants Regulates Leukocyte-Endothelial Cell Interactions in Inflammation..
• 11:30 a.m. - 12:15 p.m.
  • Alex Sevanian, Ph.D., University of Southern California, Los Angeles, CA - Derangement of Phospholipid Remodeling and Repair Pathways by Ischemia and Reperfusion.
• 12:15 - 7:00 p.m.: Afternoon Activities
• 12:30 p.m. - 01:30 p.m.: Lunch
• 01:30 p.m. - 05:00 p.m.: "ad lib. Scientific Interactions"
• 05:00 p.m. - 06:00 p.m.: Poster Session B (part 1) Chaired by Matthew B. Grisham, Ph.D.
  • - Oxygen Radicals, Inflammation & Ischemia/Reperfusion
  • - Oxygen Radicals, Growth Arrest, Apoptosis & Cancer
  • - General Topics
• 06:00 p.m. - 07:00 p.m.: Dinner
• 7:30 p.m. - 9:00 p.m.: Evening Scientific Session
  • Chairs: Joanna M. S. Davies, M.D., Albany Medical College, Albany, NY and Matilde Maiorino, Ph.D., University of Padova, Padova, Italy
• 07:30 p.m. - 08:15 p.m.
  • Sharon Wahl, Ph.D., NIDR/NIH, Bethesda, MD - Free Radicals and Inflammatory Joint Disease.
• 08:15 p.m. - 09:00 p.m.
  • Harry Nick, Ph.D., University of Florida, Gainsville, FL - Molecular Regulation of MnSOD by Inflammatory Cytokines and LPS

Thursday, February 15, 1996

Oxygen Radicals, Growth Arrest, Apoptosis & Cancer

• 8:45 a.m. - 12:15 p.m.: Morning Scientific Session
  • Chairs: Brooke T. Mossman, Ph.D., University of Vermont, Burlington, VT and Giuseppe Poli, Ph.D., University of Turin, Turin, Italy
• 08:45 a.m. - 09:00 a.m.: Announcements and Chair's Introductory Remarks
• 09:00 a.m. - 09:40 a.m.
  • Enrique Cadenas, Ph.D., University of Southern California, Los Angeles, CA -Reactive Oxygen Species Generated by Anticancer Quinones Induce p21 in Tumor Cells.
• 09:40 a.m. - 10:20 a.m.
  • Catherine Pasquier, Ph.D. I.N.S.E.R.M, Paris, France - Role of Oxygen Radicals in Polymorphonuclear Cell Apoptosis.
• 10:20 a.m. - 10:40 a.m.Coffee Break
• 10:40 a.m. - 11:20 a.m.
  • Angelo Azzi, University of Bern, Bern, Switzerland - Control of Cell Proliferation by a-Tocopherol.
• 11:20 a.m. - 12:00 p.m.
  • Dana R. Crawford, Ph.D., Albany Medical College, Albany, New York - Transient Growth Arrest During Adaptation to Oxidative Stress.
• 12:00 p.m. - 12:30 p.m.Conference Business Meeting:
  • Chaired by Donald J. Reed, Ph.D., Oregon State University, Corvallis, OR (Immediate-past Gordon Conference Chair).
  • Election of New Vice-Chair(s) and Conference Evaluation
• 12:30 - 7:00 p.m.: Afternoon/Evening Activities
• 12:30 p.m. - 01:30 p.m.: Lunch
• 01:30 p.m. - 05:00 p.m.: "ad lib. Scientific Interactions"
• 05:00 p.m. - 06:00 p.m.: Poster Session B (part 2) Chaired by Matthew B. Grisham, Ph.D.
  • - Oxygen Radicals, Inflammation & Ischemia/Reperfusion
  • - Oxygen Radicals, Growth Arrest, Apoptosis & Cancer
  • - General Topics
• 06:00 p.m. - 07:30 p.m.: CONFERENCE BANQUET & Iron Bolt Award
• 8:00 p.m. - 9:00 p.m. : Conference Keynote Lecture
  • Sten Orrenius, M.D., Institute of Environmental Medicine, the Karolinska Institute, Stockholm, Sweden Redox Regulation of Apoptotic Cell Death
  • Chair: Kelvin J. A. Davies, Ph.D., D.Sc., Albany Medical College

Friday February 16, 1996 - Depart Ventura