| Sunday |
| 2:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Genotypic Precision Medicine and Phenotypic Personalized Medicine |
| Discussion Leader: Bill Gahl (National Human Genome Research Institute, NIH, USA) |
| 7:40 pm - 7:55 pm | Introduction by Discussion Leader |
| 7:55 pm - 8:35 pm | Bruce Gelb (Icahn School of Medicine at Mount Sinai, USA)
"Getting Personal: The Path from Congenital Heart Disease Genetics to Better Outcomes" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:25 pm | Wee Joo Chng (Cancer Science Institute of Singapore, National University of Singapore, Singapore) and Edward Kai-Hua Chow (Cancer Science Institute of Singapore, National University of Singapore, Singapore)
"Phenotypic Personalized Medicine in Multiple Myeloma" |
| 9:25 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Personalized/Precision Medicine and Enabling Technologies |
| Discussion Leader: Megan Frisk (Science Translational Medicine, USA) |
| 9:00 am - 9:15 am | Introduction by Discussion Leader |
| 9:15 am - 9:55 am | Steven Rosen (City of Hope National Medical Center, USA)
"RNA Directed Therapy
(8 Chloro-Adenosine), DNA Directed Therapy (Leflunomide) and Targeting Glucose
Metabolism (Ritonavir Plus Metformin) – Bench to Bedside for AML and Myeloma" |
| 9:55 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Group Photo / Coffee Break |
| 10:40 am - 11:20 am | Dean Ho (Weintraub Center for Reconstructive Biotechnology, University of California, Los Angeles, USA)
"Phenotypic Personalized Medicine: Actionable Individualization of Patient Therapy" |
| 11:20 am - 11:35 am | Discussion |
| 11:35 am - 12:15 pm | Geoffrey Ginsburg (Duke Center for Applied Genomics and Precision Medicine, USA)
"Novel Paradigms for the Early Detection of Acute and Chronic Disease" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Megan Frisk (Science Translational Medicine, USA) |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Personalized Pediatric Medicine |
| Discussion Leader: Katherine Janeway (Dana-Farber Cancer Institute, Harvard University, USA) |
| 7:30 pm - 7:45 pm | Introduction by Discussion Leader |
| 7:45 pm - 8:25 pm | Dennis Lo (Chinese University of Hong Kong, Hong Kong SAR China)
"Unlocking Hidden Diagnostic Information from Plasma DNA" |
| 8:25 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Charles Roberts (St. Jude Children's Research Hospital, USA)
"SWI/SNF (BAF) Complex Mutations in Cancer: Mechanisms and Therapeutic Vulnerabilities" |
| 9:20 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Intersection
of Engineering and Medicine |
| Discussion Leader: Hsing Jien Kung (National Health Research Institutes, Taiwan) |
| 9:00 am - 9:15 am | Introduction by Discussion Leader |
| 9:15 am - 10:00 am | Yanyi Huang (Peking University, China)
"Connection Between the Heterogeneous Phenotypes and Genotypes at Single-Cell Level" |
| 10:00 am - 10:15 am | Discussion |
| 10:15 am - 10:30 am | Coffee Break |
| 10:30 am - 11:15 am | Garry Nolan (Stanford University, USA)
"Single Cell Deep Profiling of Cancer and Immunity" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 12:15 pm | Pasi Janne (Dana-Farber Cancer Institute, USA)
"Strategies to Overcome Drug Resistance in EGFR Mutant Lung Cancer" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 2:00 pm - 4:00 pm | Poster Session |
| 4:00 pm - 6:00 pm | Individualized Medicine for Cancers |
| Discussion Leader: Richard Weinshilboum (Mayo Medical School, Mayo Clinic, USA) |
| 4:00 pm - 4:15 pm | Introduction by Discussion Leader |
| 4:15 pm - 4:55 pm | Xianting Ding (Institute for Personalized Medicine, Shanghai Jiao Tong University, China)
"In Vivo Drug Combination Optimization for Colon Cancer Treatment Through a Phenotype Personalized Medicine (PPM) Approach" |
| 4:55 pm - 5:10 pm | Discussion |
| 5:10 pm - 5:50 pm | Arjan Griffioen (VU University Medical Center, The Netherlands) and Patrycja Nowak-Sliwinska (University of Geneva, Switzerland)
"Identification of Optimal Personalized Combination Therapy for Renal Cell Cancer" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm | Dinner |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Genomics
and Molecular Targets |
| Discussion Leader: Garry Cutting (Johns Hopkins University, USA) |
| 9:00 am - 9:15 am | Introduction by Discussion Leader |
| 9:15 am - 9:55 am | Pan-Chyr Yang (National Taiwan University, Taiwan)
"Precision Lung Cancer Therapy: EGFR-TK1 and Beyond" |
| 9:55 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:20 am | C. Thomas Caskey (Baylor College of Medicine, USA)
"Metabolomics Adds Function to Genetic Precision Medicine" |
| 11:20 am - 11:35 am | Discussion |
| 11:35 am - 12:15 pm | William Mobley (University of California, San Diego, USA)
"Defining Genes and Mechanisms Underlying Cognitive Deficits in Down Syndrome" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Personalized Therapies for Blood Disorders |
| Discussion Leader: Qiang Tian (P4 Medicine Institute, USA) |
| 7:30 pm - 7:45 pm | Introduction by Discussion Leader |
| 7:45 pm - 8:25 pm | Andrew Feldman (Mayo Clinic Cancer Center, USA)
"Individualizing Therapy in Lymphoma" |
| 8:25 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Karl Tsim (Hong Kong University of Science and Technology, Hong Kong SAR China) and Yi-Kuen Lee (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Traditional Chinese Medicine: A Yin-Yang Balance of Personalized Medicine" |
| 9:20 pm - 9:30 pm | Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Personalized Immunotherapy |
| Discussion Leader: Patrick Tan (Duke-NUS Medical School, Singapore) |
| 9:00 am - 9:15 am | Introduction by Discussion Leader |
| 9:15 am - 10:00 am | Yusuke Nakumura (Center for Personalized Therapeutics, University of Chicago, USA)
"Cancer Precision Medicine and Neoantigen Vaccine Treatment" |
| 10:00 am - 10:15 am | Discussion |
| 10:15 am - 10:30 am | Coffee Break |
| 10:30 am - 11:15 am | Lieping Chen (Yale University, USA)
"The PD-1/PD-L1 Blockade: A New Class of Cancer Immunotherapy" |
| 11:15 am - 11:30 am | Discussion |
| 11:30 am - 12:15 pm | Ali Zarrinpar (David Geffen School of Medicine at UCLA, USA)
"Patient-Specific Drug Interaction Mapping in Personalized Immunosuppression" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Late-Breaking Topics |
| Discussion Leader: Yiwu He (BGI, China) |
| 4:00 pm - 4:20 pm | Introduction by Discussion Leader |
| 4:20 pm - 4:50 pm | Gunaretnam Rajagopal (Janssen R&D, USA) and Zhen Gu (University of North Carolina at Chapel Hill, USA)
"Integration of GPM. PPM and Enabling Technologies" |
| 4:50 pm - 5:00 pm | Discussion |
| 5:00 pm - 5:30 pm | Navaline Quach (Tecan, USA) and Julia Zhen (Thermo Fisher Scientific, USA)
"Industrial Participation and Government Regulatory Process" |
| 5:30 pm - 5:40 pm | Discussion |
| 5:40 pm - 6:00 pm | General Discussion |
| 6:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
