Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Signals and Forces in Leukocyte Activation
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
"Beta2 Integrin Activation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
"The Response of Phagocytes to Cell Shape Changes"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Phagocyte Function, Immunity and Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Metabolic Regulation of Macrophage Functions"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Monocytes: Soldiers in Health and Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"LncRNA MERRICAL In-Cis Regulates CCL3/4 and Macrophage Chemotaxis in Diabetes-Associated Atherosclerosis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
"NLRP3 Inflammasome Activation in Neutrophils"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Pathological Lung Inflammation and Remodeling in Cystic Fibrosis: Are Macrophages the Culprit?"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Neutrophils: Life After Death"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"NETs in Post-COVID Patients with Thromboembolism"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytes in Inflammatory Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Understanding the Mechanisms Whereby Slan-Positive Monocytes Kill Cancer Cells During ADCC"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"The Proliferating Cell Nuclear Antigen (PCNA) as a Versatile Regulator of Neutrophil Activation in Inflammatory Diseases"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Macrophages Promote Tumor Cell Extravasation Across an Endothelial Barrier Through Thin Membranous Connections"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Investigating the Impact of Blocking L-Selectin Shedding in Deep Vein Thrombosis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Resolvin D4 Regulates Excessive Neutrophil Deployment During Infection"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Immunity, Autophagy and Cell Death
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Trojan Horse: Two T6SS Effectors Induce Pyroptosis upon Phagocytosis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Regulation of Neutrophil-Mediated Inflammation by ELMO1"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Metainflammation Impacts Neutrophil Biology: Lessons from the Zebrafish"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Specific Signaling by Fc Receptors in Human Neutrophils"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Neutrophil Extracellular Traps"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Coordination of Non-Apoptotic Cell Death and Clearance in the Drosophila Ovary"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"SQST-1/p62 and SKN-1/NRF2 Promote Phagocytosis Under Stress by Promoting Lysosomal Trafficking"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Migration and Differentiation in Immunity and Inflammation
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"A Developmental Approach on Liver Immune and Metabolic System Under the Eyes of High Dimensional Intravital Microscopy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Dissecting the Mechanisms that Regulate Neutrophil Chemotaxis and NET Release"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Novel Biosensors for the Real-Time Measurement of LTB4 and Further Chemoattractant Gradients"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"PD-L1 Regulates the Development of Inflammatory Macrophages from Human Stem Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"In Vivo Deuterium Labeling of Neutrophil Precursors in Human Bone Marrow Identifies a Linear Conveyor Belt Structure of Neutrophil Development"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Phagocytosis in Macrophages and Dendritic Cells
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Using DNA Origami to Understand Phagocytic Signaling"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Apolipoprotein Control of Antigen Cross-Presentation by Classical Dendritic Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Excess Plasma Membrane Mechanically Regulates Functional Decision-Making in Myeloid Cells"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Determinants of Phagocytic Appetite Exhaustion and Recovery"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Quiescent Actin Dynamics Following Phagocytosis: Macrophages Hibernate After a Large Meal"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Investigating Sphingolipid Dynamics During Phagocytosis Using Novel Genetically-Encoded Fluorescent Probes"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Macrophage-Mediated Intracellular and Extracellular Control of Aspergillus Fumigatus Fungal Infection in Larval Zebrafish"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microglia, Phagocytosis in the Central Nervous System
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Phagocytosis Within Neural Circuits: A Synapse Makes for a Good Meal"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Phagocytic Type I Interferon-Responsive Microglia in Brain Development"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"The Role of the Non-Canonical Inflammasome in Macrophages and Microglia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A New Approach in Glioma Therapy: DC Vaccines Loaded with Immunogenic Lysates Induce Efficient Anti-Tumor Immunity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Deciding What to Eat; When Neutrophils Have a Taster but Not a Second Course"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Phagocytes in Host-Pathogen Interaction
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Multi-Scale Spatial Organization in Pathogen-Host Interactions: From Membrane Crosstalk to Phagosome Maturation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Manipulating Efferocytosis: A New Role for P.gingivalis Proteases"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Deciphering Mechanisms of Cell-to-Cell Transfer of HIV-1 Towards Macrophages and Their Modulation in Co-Infection with Mycobacterium Tuberculosis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"A Cell-Intrinsic Host Defense Pathway that Controls Salmonella Intracellular Replication"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"To Protect a Host: Unwinding the Mechanisms of Helminth Antigens in Reprogramming Host Myeloid Cells"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"An Infection-on-a-Chip Microfluidic Device for Investigating How Multicellular Interactions Impact the Innate Immune Response to Infection"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Neutrophils Control T Cell Responses to the Pneumococcal Conjugate Vaccine"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phagocytes, Mucosal Immunity and the Microbiota
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"The Microbiota and Development of Intestinal Immunity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Neutrophils and the Black Death: Yersinia Pestis Actively Inhibits the Synthesis of Leukotriene B4 During Infection"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Alveolar Macrophage Innate Sentinel Response to Mycobacterium tuberculosis "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Neutrophils Drive Mucosal Inflammation by Reprogramming Their Oxidative Repertoire"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure