Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Hub of Signal Integration
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Environmental ERKonomics"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism: Ying and Yang of Metabolic Signaling Networks
9:00 am - 9:30 am
"Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Kinase-Mediated Regulation of Muscle Glucose Disposal"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"AMP Kinase-Mediated Selective Activation of Astrocyte Glycolysis via Phosphorylation of PFKFB3 as a Novel Therapeutic Approach in Alzheimer's Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Inflammation-Resolving Lipid Mediators and Their Receptors"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Chaperone Mediated Assembly of mTOR Complexes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"An Alternative G Protein Signaling Pathway Leads to Autophagy in Saccharomyces cerevisiae "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroscience: Wiring the Neuron by Phosphorylation and G-Proteins
7:30 pm - 8:00 pm
"Loss of Opioid and Gi-Dependent Inhibition of Adenylyl Cyclase After Spinal Cord Injury"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Rho Regulator-Mediated Signaling in Inter-Neuron Development and Disease"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Unmasking Aberrant Phosphorylation Networks in 16p11.2 CNV Associated Autism"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:30 am
"PI3Kbeta Signaling in Invasion and Metastasis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Interrogating Purinergic Signaling: From Extracellular ATP to Intracellular Second Messenger Dynamics"
9:50 am - 9:55 am
Discussion
9:55 am - 10:25 am
"PTEN and the Digital Signaling Hub"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Gs Protein Subunits Avoid, but Are Not Excluded from, Clathrin-Coated Pits"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"RGS10 Regulates COX-2 and TNFalpha Through G Protein Independent Mechanisms"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Structural Basis of Opioid Receptor Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre-Coupled Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiovascular System and Vascular Networks
7:30 pm - 8:00 pm
"Subcellular Control of Phospholipase Cepsilon Signaling in Cardiac Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"PZR Tyrosyl Phosphorylation Is Associated with Hypertrophic Cardiac Gene Expression in Shp2 Associated NSML Model Mice"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"High Speed Measurement of Agonist-Induced cAMP Signals in Single Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"G-Protein-Dependent and -Independent Signaling of Orphan Adhesion GPCR, GPR64"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Visualization and Model Systems in Signaling
9:00 am - 9:30 am
"Spatial Compartmentalization of Second Messengers and Kinase Complexes in Living Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"G Protein-Mediated Autophagy in Yeast"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Quantitative Analyses of Chemoattractant-Induced Heterotrimeric G Protein Activation Kinetics in Dictyostelium Reveal Important Role for High Affinity Pre-Coupled Receptors"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Integrating Chemical and Mechanical Signals Through Dynamic Coupling Between Protrusions and ERK Activation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"The Allostery in G Protein Coupling: From G Proteins to Small Molecules to Cations"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Identity Matters: Ggamma-Type Dictates Efficacy of Gbetagamma Signaling and Cellular Decisions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Conformational Regulation of Phospholipase C Enzymes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cyclic Nucleotides and GPCR Signaling
7:30 pm - 8:00 pm
"Toward a Spatiotemporal Logic of Cellular GPCR Signaling by cAMP and PKA"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Negative Feedback Phosphorylation of G Gamma Subunit Ste18 and the Ste5 Scaffold Synergistically Regulates MAPK Activation in Yeast"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"MAPK Pathway Regulation of Heterotrimeric G Protein Signaling Tone"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Therapeutic Targeting of GPCR Gbetagamma-GRK2 Signaling in Osteoarthritis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Nexus of Phosphorylation and G-Protein Signaling
9:00 am - 9:30 am
"Regulation of the Hippo Pathway"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"New Approaches to Exploiting PTP1B as a Therapeutic Target"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Chemical Approaches to Identifying Kinase and Phosphatase Substrates"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Non-Cell Autonomous Regulation of mTORC1-Dependent Feedback Mechanisms"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Targeting RGSz1 Pathways for the Treatment of Chronic Pain"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanisms Inducing Opioid Resistance After Spinal Cord Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"ICK Signaling in Ciliopathy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer Biology and Protein Phosphorylation
7:30 pm - 8:00 pm
"Oncogenic B-Raf Signaling in Melanoma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"GPCR Signaling and Cancer Immune Therapies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Biological Cross-Talk Between WNK1 and TGF-Beta Signaling Pathway"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Unraveling a Role for PKA in Mammary Development and Tumor Progression"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure