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Plasminogen Activation and Extracellular Proteolysis

Gordon Research Conference

Thrombolytic Enzymes: Biology and Biomedical Practice

February 9 - 14, 2020

Chairs

and

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The GRC on Plasminogen Activation and Extracellular Proteolysis presents breakthrough findings on the biological functions of these proteases and discusses their translational importance in key scientific areas: aging, cardiovascular diseases and angiogenesis, neurological and neuropsychiatric diseases, cell death, inflammation, infection, tissue homeostasis and regeneration, tumor biology, and renal function. Technological advances in understanding the biology of extracellular proteolysis will also be discussed. The translational importance of the new discoveries presented in each session will be emphasized, and the identification of the basic research areas, that need to be developed in the future to meet specific clinical needs, will be introduced. Technological advances in genomics, proteomics, and imaging of extracellular proteolytic systems will be presented. Guided in engaging discussions led by senior investigators in the field, new and exciting research will be presented and younger/new to the field investigators will be welcome and integrated into the conference.

Related Meeting

This GRC will be held in conjunction with the "Plasminogen Activation and Extracellular Proteolysis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: The Next or New Opportunities in the Plasminogen Activation and Extracellular Proteolysis Field Session in memory of Ed Reich and Russell Doolittle. Discussion Leader:
7:40 pm - 7:50 pm	Opening Remarks
7:50 pm - 7:55 pm	Introduction by Discussion Leader
7:55 pm - 8:30 pm	"Understanding the Molecular Regulation of Plasminogen Activation as a Key to Future Fibrinolysis Research"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Fibrinolysis Research: A Look Back and Forward"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Cardiovascular Function and Coagulopathies Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Proteolytic Regulation of Platelet Receptor Levels in Patients with Cardiovascular Complications"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Mechanisms Linking Fibrinogen and Fibrinolysis to Liver Repair"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Alpha-2-Macroglobulin and Hemostasis Disorders in Chronic Inflammatory Diseases"
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"The Activated Platelet Membrane: A Key Site for Plasminogen Activation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"The Evolution of Defining Fibrinolysis Dysfunction Following Severe Injury"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"The Role of TAFI in Hemophilic Arthropathy"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Musculoskeletal Disease Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"The Multifaceted Role of Fibrin/Fibrinolysis in Musculoskeletal Biology"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Roles of Plasminogen Activator Inhibitor-1 in Bone Metabolism"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Fibrin Is a Critical Regulator of Mucosal Immunopathology"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"The Yin and Yang of Neutrophil Elastase in Muscle Regeneration and Dystrophy"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Metabolic Diseases and Aging Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Association of Adipose Tissue Factor XIII-A with Metabolic Health in Mice and Humans"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Assessing In Situ Plasmin Generation in Health and Disease"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Prothrombotic Complications and Resistance to tPA-Mediated Fibrinolysis in Sickle Cell Disease"
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Regulation of Macrophages by Plasmin During Liver Repair"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Protective Effects of a High Fat Diet on Alzheimer's Disease Pathophysiology"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"14K Fragment of Growth Hormone and Its Derived Peptides Promote Fibrinolysis and Protect from Thrombosis by Binding Plasminogen Activator Inhibitor"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"The Time-Dependent Role of Plasmin in Muscle Repair and New Considerations for Antifibrinolytic Drug Administration Following Trauma and Surgery"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cancer and Signaling Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"The Fibrinolytic System Orchestrates the Development of Inflammation and Inflammation-Associated Carcinogenesis in the Proteolytic Niche"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"TAFI and Thrombomodulin as Inhibitors of Breast Cancer Metastasis"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"PA System in Skin Cancer Progression"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Urokinase Receptor as a 'Trap' for Urokinase: Binding of uPA to uPAR Prevents Nuclear Translocation of uPA and EMT in Neuroblastoma Cells"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	New Technologies and Therapeutic Advances Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Magnetically Powered Microbots for Fibrinolysis"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"uPAR Inhibitory Nanomedicine for Targeted Treatment of Sterile Inflammatory Diseases"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Thrombin Signaling Promotes Pancreatic Adenocarcinoma Through PAR-1-Dependent Immune Evasion"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Defining High-Risk Heart Failure with Preserved Ejection Fraction Through Inflammatory Burden: The Role of sUPAR"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Multi-Channel Fluorescent Imaging of Hemostatic Proteases for the Monitoring of Therapeutic Efficacy"
11:25 am - 11:35 am	Discussion
11:35 am - 11:55 am	"Resistance to Fibrinolysis and New Thrombolytic Strategies: Insights from Intravital Microscopy, Microfluidics and Ex Vivo Thrombolysis Assays"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Spatiotemporal Regulation of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Activation on Activated Platelets"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Urokinase Regulates N-Cadherin-Mediated Synaptic Formation in the Ischemic Brain"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Late-Breaking Topics Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Plasmin(ogen) and the Traumatically Injured Patient: Friend or Foe?"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"Hepatocyte-Derived tPA Regulates Systemic Fibrinolysis"
8:15 pm - 8:25 pm	Discussion
8:25 pm - 8:40 pm	"PAI-1 Drives the Development of Lung Fibrosis Through Novel Protein Interactions"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"The Role of Localized Proteolytic Environments in Group A Streptococcal Pathogenesis"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Membrane-Anchored Serine Proteases in the Regulation of Vascular Permeability"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Infection and Immunity Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"SuPAR as Endogenous Immunotoxin for the Kidney"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Extracellular Proteases in Sepsis: Translating Basic Research to Precision Medicine"
9:55 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Plasminogen Activator Inhibitor-1 (PAI-1) Targeted Fibrinolytic Therapy in Rabbit Empyema Model"
10:25 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"New Horizons in Translating Selective Anti-MMP Biological Inhibitors into the Clinic"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Derangements of uPA and PAI-1 Activity in Severe Cases of Hantavirus Cardiopulmonary Syndrome"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Modulation of Fibrinogen/Fibrin Levels Affects the Outcome of Enterococcal Catheter-Associated Urinary Tract Infections"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Fibrinogen Deficiency Leads to Stabilization of 14-3-3-Sigma and P53 Which Control Colorectal Adenocarcinoma Growth"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Neurological and Neuropsychiatric Diseases Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Cerebrovascular Pathology in Cognitive Impairment"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"tPA Modulation of the Blood-Brain Barrier"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Proteolytic Regulation of Glial Activation and Neuroinflammation"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"New Thrombolytic Therapies for Ischemic Stroke"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL150867. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Plasminogen Activation and Extracellular Proteolysis (GRS)

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