Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Plasminogen Activation and Extracellular Proteolysis in Therapy
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
"Elucidation of the Molecular Mechanism of Two Nanobodies that Inhibit PAI-1 Activity"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Repurposing Amiloride into uPA/NHE1 Dual Targeting Candidates for the Treatment of Metastatic Cancer"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Proteolysis in Regulation of Innate Immune Responses, Inflammation and Cancer / Keynote Session: Biophysical Properties of the Extracellular Matrix and Tumor Progression
Our keynote speaker will be Valerie Weaver of UCSF.
7:30 pm - 7:45 pm
"Lympho-Epithelial Kazal-Type-Related Inhibitor (LEKTI) Inhibits Matriptase-Dependent Carcinogenesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Expression of Testisin Reduces Ovarian Tumor Metastasis Through a PAR-2 - Angiopoietin Signaling Pathway"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Fibrin Is a Critical Regulator of Immunopathology at the Oral Mucosal Barrier"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Biophysical Properties of the Extracellular Matrix and Tumor Progression"
9:15 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mentorship Component: Taking a Basic Science Discovery from Bench to Bedside / Extracellular Proteases in Thrombosis and Hemostasis
The Mentorship Component portion of the session will be a discussion panel with scientists who took the basic science discovery through from the lab to commercializing in form of founding a startup company or pushing the discovery to clinical trials.
9:00 am - 10:00 am
Panel Discussion
Taking a Basic Science Discovery from Bench to Bedside: A Step by Step Guide for Early Career Scientists
10:00 am - 10:15 am
"The Role of Plasminogen Activator Inhibitor Type-2 (PAI-2) in Modulating Venous Thrombus Resolution"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"The Influence of Plasmin on Blood-Brain Barrier Integrity and the Systemic and Local Immune Profile in Traumatic Brain Injury Is Gender-Dependent and Differentially Modulated by Tranexamic Acid"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Effect of Ketamine on Lipopolysaccharide Induced Depression-Like Behavior in Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Extracellular Proteolysis in Tissue Development, Homeostasis, and Repair
1:30 pm - 1:45 pm
"Selective Deletion of LRP1 in Smooth Muscle Cells Results in Abdominal and Thoracic Aortic Aneurysms, TGF-Beta Activation, and Cerebral Artery Aneurysm"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"A Cross-Talk Between Neuronal Urokinase-Type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Synaptic Recovery in the Ischemic Brain"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
"Attenuation of Immune Cell-Secreted Serine Protease Granzyme B Reduced Tissue Damage and Improves Functional Recovery Following Spinal Cord Injury"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes