Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Plasminogen Activation System: Emerging Techniques and Potentials for the Development of New Therapeutics
3:45 pm - 4:20 pm
"Plasminogen Activation System: Emerging Techniques and Potentials for the Development of New Therapeutics"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Proteases in Cancer Biology, Tissue Remodeling and Neurobiology
7:30 pm - 7:45 pm
"LRP1 and SORLA Regulate Tau Binding, Endocytosis, Degradation, and Seeding"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Proteomic and Proteolytic Landscape of Acute Human Skin Repair"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Changes in Extracellular Proteolysis and Neurovasculature in a Rodent Model of Depression"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Validation of a Novel Retained Hemothorax Rabbit Model as a Platform to Test Pharmacological Interventions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Novel Assay to Measure Fibrinolytic Activity and for the Personalization of Fibrinolytic Therapy for Empyema"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Developing RNA Gene Therapies to Modulate Circulating Plasminogen Activator Inhibitor 1"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Extracellular Proteases in Cardiovascular, Immunological Disorder and Thrombotic Disorders
9:00 am - 9:15 am
"Absence of Fibrinolysis Activation Explains Inefficacy of TXA to Reduce Bleeding in Hypoproliferative Thrombocytopenia Patients in A-TREAT Clinical Trial"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Improved In Vivo Fibrinolysis of Clots via tPA Coated Beads"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Plasminogen receptors promote lipoprotein(a) uptake by enhancing surface binding and facilitating macropinocytosis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Silencing Hepatocyte Tissue Plasminogen Activator Increases Plasma apoB lipoprotein-cholesterol by Promoting MTP-Mediated VLDL Lipidation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"The LDL Receptor-Related Protein 1 (LRP1) Serves as Host Factor for SARS-CoV-2"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Lipoxin A4, Maresin 1 and Resolving D1 as Key Factors for the Actions of Plasminogen/plasmin on Inflammation Resolution"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Landing on the Right Job After Your PhD or Postdoc
1:30 pm - 2:30 pm
Panel Discussion
Landing on the Right Job After Your PhD or Postdoc
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes