Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Emerging Studies in the Translational Research of Fibrinolysis
Discussion Leader: Ali Citalan-Madrid (University of Michigan, United States)
3:45 pm - 4:15 pm
Ian Roberts (LSHTM, United Kingdom)
"The Story of Tranexamic Acid in Acute Severe Bleeding"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Plasminogen Activators and Proteases in Cardiovascular and Infectious Disorders
Discussion Leader: James Hucklesby (University of Auckland, New Zealand)
7:30 pm - 7:45 pm
Jonathan Molina (University of Notre Dame, United States)
"Host Fibrinolytic Deficiencies Enhance Pathogen Colonization in the Catheterized Bladder Environment and Promote Systemic Dissemination"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Soranyi Canelo (Medical College of Wisconsin (MCW), United States)
"Investigating the Potential Role of HSP47 in PAI-1 Deficiency-Associated Cardiac Fibrosis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Hana Lim (Weill Cornell Medicine, United States)
"Annexin A2 Proteolysis in Sepsis: An Adaptive Survival Mechanism that Dampens Macrophage-Driven Systemic Inflammation"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Joshua Rich (National Cancer Institute, United States)
"Mapping the Interactome of Matrisome Targets Using Extracellular Proximity Labeling (ePL)"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Jack Toor (National Institutes of Health, United States)
"Site-Specific PEGylation of TIMP2 to Generate an Improved Potential Biotherapeutic"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Armando Marrufo (University of Notre Dame, United States)
"Urinary Catheterization-Induced Fibrin Accumulation Activates M2 Macrophage Polarization to Promote Bacterial Colonization"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Fibrinolysis and Proteolysis in Cancer, Neurological Disorders and Tissue Remodeling
Discussion Leader: Zimu (Christine) Wei (Michigan State University, United States)
9:00 am - 9:15 am
Dillon Bohinc (Case Western Reserve University, United States)
"Canonical and Non-Canonical FXII Functions Synergistically Drive Ovarian Cancer-Associated Thrombosis and Tumor Progression"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
James Hucklesby (University of Auckland, New Zealand)
"Surface-Bound Plasminogen Triggers a Substantial Temporal Decline in the Barrier Integrity of Brain Microvascular Endothelial Cells"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Ashna Kumar (University of Wollongong, Australia)
"A “Peak” Into the Intratumoural Distribution of a Novel Anti-Metastatic Urokinase-Selective Inhibitor via Mass Spectrometry Imaging in Human Pancreatic Ductal Adenocarcinoma"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Zimu (Christine) Wei (Michigan State University, United States)
"Cellular Coagulation Factor XIII Drives Liver Regeneration Independent of Fibrin Cross-Linking"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Sophie Shifman (Stony Brook University, United States)
"Plasminogen Activator Inhibitor-1 in Autophagy Within the Glioblastoma Tumor Microenvironment"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Ali Citalan-Madrid (University of Michigan, United States)
"The Role of Plasminogen Activator Inhibitor, PAI-1, in Microvascular Remodeling in the 5xFAD Alzheimer’s Disease Mouse Model"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Beyond the Bench: Career Directions for Trainees in Science
Discussion Leader: Joshua Rich (National Cancer Institute, United States)
1:30 pm - 1:40 pm
Matthew Whelihan (Prolytix, United States)
"Transitioning from Academics to Industry"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
Kimberly Thomas (Vitalant Research Institute, United States)
"Three (Not Two!) Roads Diverged in a Wood, and I Took the One Less Traveled. Perhaps, Making All the Difference?"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
Ze Zheng (Medical College of Wisconsin; Versiti Blood Research Institute , United States)
"Follow Your Heart and Research Your Dream"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
Christian Kastrup (Versiti Blood Research Institute, United States)
"Enhancing and Navigating Academic Research Through Entrepreneurship"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes