| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Physiological and pathophysiological roles |
| Discussion Leader: Susan Gilmour (Lankenau Medical Research Center) |
| 7:30 pm - 8:10 pm | John Cleveland (St. Jude Children's Research Hospital)
"Pathways Regulated by Odc in Tumorigenesis" |
| 8:10 pm - 8:50 pm | Leonard Johnson (University of Tennessee)
"Polyamines and Signaling in Apoptosis" |
| 8:50 pm - 9:30 pm | Carol Colton (Duke University)
"Disruption of polyamine homeostasis in Huntington's disease, a fatal neurodegenerative disease" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Transport |
| Discussion Leader: Keiko Kashiwagi (Chiba University) |
| 09:00 am - 09:40 am | Takeshi Uemura (Chiba University)
"Identification of polyamine uptake and excretion" |
| 09:40 am - 10:20 am | Mattias Belting (Lund University)
"Uptake of polyamines and polybasic peptides via proteoglycans: Implications for tumor growth and gene delivery" |
| 10:20 am - 10:40 am | BREAK |
| 10:40 am - 11:20 am | Marie-Pierre Hasne (Oregon Health and Science University)
"Polyamine transport in Leishmania" |
| 11:20 am - 12:00 pm | Richard Poulin (Laval University Medical Research Center)
"Transport and vesicular sequestration of polyamines in mammalian cells" |
| 12:30 pm | Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mechanisms of action: RNA/translation |
| Discussion Leader: Anthony Michael (Institute of Food Research) |
| 7:30 pm - 8:10 pm | Eric Westhof (IBMC-CNRS)
"Polyamines and aminoglycosides binding to RNA" |
| 8:10 pm - 8:50 pm | Tairo Oshima (Tokyo University of Pharmacy and Life Science)
"Polyamines in life around the boiling temperature of water" |
| 8:50 pm - 9:30 pm | Kazuei Igarashi (Chiba University)
"Polyamine modulon: the regulatory genes involved in polyamine stimulation of cell growth" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanisms of action: RNA processing/eIF-5A |
| Discussion Leader: Alberto Abbruzzese (Seconda Universita Di Napoli) |
| 09:00 am - 09:40 am | Myung Park (National Institutes of Health/NIDCR)
"Post-translational modification of hypusine in eukaryotic translation initiation factor 5A (eIF5A)" |
| 09:40 am - 10:20 am | Sandro Valentini (Sao Paulo State University)
"eIF5A and mRNA metabolism" |
| 10:20 am - 10:40 am | BREAK |
| 10:40 am - 11:20 am | Annette Kaiser (German University in Cairo)
"Modification of eukaryotic initiation factor 5A from P. vivax by deoxyhypusine synthase from P. falciparum" |
| 11:20 am - 12:00 pm | Poster Presentations I |
| Discussion Leaders: Margaret Phillips (University of Texas, Southwestern) & Leena I. Alhonen (University of Kuopio) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mechanisms of action: Translational frameshifting/Antizyme |
| Discussion Leader: Senya Matsufuji (Jikei University School of Medicine) |
| 7:30 pm - 8:10 pm | Jonathon Dinman (University of Maryland)
"From IRESes and Viruses: Toward a Model of Antizyme Frameshifting" |
| 8:10 pm - 8:50 pm | Marvin Hackert (University of Texas at Austin)
"Structures of antizyme and antizyme complexes" |
| 8:50 pm - 9:30 pm | Phil Coffino (University of California, San Francisco)
"ODC to Proteasome: Should I stay or should I go?" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanisms of action: Signaling |
| Discussion Leader: Jian-Ying Wang (University of Maryland) |
| 09:00 am - 09:40 am | Lisa Shanzt (Pennsylvania State University)
"Development of a lethal phenotype in mice with cardiac overexpression of ODC" |
| 09:40 am - 10:20 am | Robert Casero (Johns Hopkins School of Medicine)
"Polyamine catabolism: A problem, a target, or both" |
| 10:20 am - 10:40 am | BREAK |
| 10:40 am - 11:20 am | Chaim Kahana (Weizmann Insitute of Science)
"Signaling ODC degradation by NAD(P)H quinone oxidoreductase" |
| 11:20 am - 12:00 pm | Poster Session Presentations II |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Pathophysiological Functions: Cancer |
| Discussion Leader: Diane McClosky (Penn State College of Medicine) |
| 7:30 pm - 8:10 pm | David Feith (Pennsylvania State University)
"Suppression of upper aerodigestive tract carcinogenesis in p53-deficient mice by an antizyme transgene" |
| 8:10 pm - 8:50 pm | Frank Berger (University of South Carolina)
"Polyamine Metabolism and Modulation of Intestinal Tumorigenesis in the ApcMin/+ mouse" |
| 8:50 pm - 9:30 pm | Frank Meyskens (University of California, Irvine)
"Clinical Prevention Trials of DFMO in Human Cancer:current status and the future?" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Clinical applications |
| Discussion Leader: Lo Persson (University of Lund) |
| 09:00 am - 09:40 am | Karen Doyle (University of California, Davis)
"Polyamines and Hearing Loss - Mechanisms of DFMO Ototoxicity" |
| 09:40 am - 10:20 am | Annette Kuesel (World Health Organization)
"Eflornithine: The 'safe' drug for a 'chronic' African disease: T.b. gambiense HAT" |
| 10:20 am - 10:35 am | BREAK |
| 10:35 am - 11:15 am | Poster Session Presentations III |
| 11:15 am - 12:00 pm | Business meeting |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Debate: Therapeutic strategies (analogs versus target-directed drugs)
dedicated to the memory of Benjamin Frydman |
| Moderator: Carl Porter (Roswell Park Cancer Institute) |
| 7:30 pm - 8:10 pm | Pro analogs: Pat Woster (Wayne State University), Heather Wallace (University of Aberdeen), Larry Marton (Cell Gate, Inc.) |
| 8:10 pm - 8:50 pm | Pro target directed: Ian Blagbrough (University of Bath), Steven Ealick (Cornell University), Vic Levin (University of Texas, MD Anderson Cancer Center) |
| 8:50 pm - 9:00 pm | Summary |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
