Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Recent Molecular Discoveries
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Polyamines and Non-Coding RNAs in Gastrointestinal Epithelial Homeostasis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Hypusination in Macrophage Function, Diabetes and Metabolic Inflammatory Disease"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"In Vivo Consequences of Polyamine Imbalance: Insights from a Drosophila Model of Snyder-Robinson Syndrome"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Cancer Prevention and Treatment
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Neuroblastoma Trials and DFMO"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Colorectal Cancer Biomarkers and Prevention with DFMO"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Group Photo / Coffee Break
10:55 am - 11:25 am
"Targeting Polyamines in Pancreatic Cancer"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Gastric Cancer Prevention: Polyamines as Targets and Novel Effects of DFMO"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Leveraging Polyamine Metabolic Stress to Enhance Sensitivity to Epigenetic Therapy for Prostate Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Advances in Inflammation and Cancer Biology
7:30 pm - 8:00 pm
"Oncogenic Signals Upstream and Downstream of Polyamine Biosynthesis in Prostate Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Tumor Immunology and Polyamines"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Drug Strategies Targeting Polyamines in Cancer Biology"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Arginine Metabolism: Upstream Factors in Disease Models
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Arginine Metabolism in Leishmania, Gene Expression Regulation and the Fate of the Infection"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Arginase 2 Suppresses Renal Carcinoma via Increased Polyamine Toxicity"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Arginine Utilization by Macrophages in the Control of Intracellular Pathogens"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Arginine and Its Metabolism in Inflammatory Bowel Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations / Late-Breaking Topics
7:30 pm - 7:40 pm
"Genetic Variability in ODC1 Intron 1 Hosted SNORA80B, a Small Nucleolar (sno)RNA, and Its Potential Consequences on rRNA Processing"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Polyamine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Polyamine Synthesis in Response to Efferocytosis Regulates Anti-Inflammatory Reprogramming of Macrophages"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Functions of Polyamines Produced by the Intestinal Microbiome in Healthy Mice and Humans"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Metabolism of Apoptotic Cell-Derived Arginine and Ornithine into Putrescine by Macrophages Promotes Continual Efferocytosis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Role of Polyamines in Anticancer Drug Resistance"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamines in Aging and Other Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Polyamines, Synaptic Plasticity, Autophagy and Aging"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Dietary Spermidine Against Age-Associated Decline"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Polyamines as Protective Disease Modifiers in Congenital Muscular Dystrophy"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"SMOX Overexpression: Differential Effects in Skeletal Muscle and Nervous System"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Macrophage Reverse Transsulfuration Pathway Mediates Helicobacter pylori Immunopathogenesis by Regulating Polyamine Synthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Control of Polyamine Levels and Signaling
7:30 pm - 8:00 pm
"STREAP (STop-REad-Pause) Mechanism in the Translation of mRNA Encoding a Key Polyamine Pathway Enzyme AdoMetDC"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"EIF5A Is a Sensor and Effector for Polyamine Regulation of Antizyme, Antizyme Inhibitor, AdoMetDC and Polyamine Transporter Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Physiological Functions of Polyamines and Their Metabolite, Acrolein"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Roles of Polyamines: Biofilms, Microbiome, Plants and Viruses
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Effects of Polyamines on Vibrio cholerae Biofilms"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"The Genetic Analyses of Polyamine Transport and Biosynthesis in the Dominant Human Gut Microbes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Ebolavirus Is Addicted to Polyamines and Hypusinated eIF5A"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"S-Adenosylmethionine Decarboxylase in Arabidopsis "
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"ODC1: A Rare Patient, a Chance Meeting, a New Genetic Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Polyamines and Cancer Biology
Session in memory of Seymour Cohen.
5:30 pm - 5:40 pm
"Investigating the Biology of DHPS Deficiency, a New Monogenic Disease"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Regulation of Ornithine Decarboxylase (ODC) Induction by UVB Is Dependent on mTORC1 in Human Keratinocytes"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Understanding the Polyamine Stress Response in Tauopathies"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:20 pm
Introduction by Discussion Leader
6:20 pm - 7:00 pm
"Polyamines in Cancer Biology: Past, Present and Future"
7:00 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure