Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 8:05 pm
"Polyamine Synthesis and Hypusination Prepare Fibroblasts for Collagen Production and Proliferation after Lung Injury"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Dysregulations in Putrescine Metabolism Drive Hepatic Fibrosis in MASH"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"The Role of Spermidine in Cancer Immunotherapy and Aging"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamine-Based Therapies and Clinical Trials
9:00 am - 9:25 am
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Turning Up the Heat: Reprogramming the Tumor Immune Microenvironment via Polyamine Depletion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Polyamines Wobble a Proliferative Switch in Neuroblastoma: Therapeutic Implications"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Polyamines Under Stress: Autophagy and Polyamine-Metabolism in Stress-Related Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic Disorders and Polyamines
7:30 pm - 7:55 pm
"Clinical Aspects of DHPS Deficiency"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Bachmann-Bupp Syndrome: Clinical and Biochemical Analysis of DFMO Treatment"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"How Spermine Synthase Deficiency Impairs Bone Formation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Roles of Polyamines in Degenerative Disorders
9:00 am - 9:25 am
"Polyamines as Pathogenic Catalysts and Therapeutic Targets in Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Transcriptomic Analysis Highlights the Therapeutic Potential of Spermidine in ALS Mouse Models"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Spermidine: A Path to Better Rest?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"ATP13A2 LOSS of Function and Polyamine Deficiency Cause Epigenetic Reprogramming of Astrocytes to an Inflammatory State Toxic to Dopaminergic Neurons"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hypusination and Translation
7:30 pm - 7:55 pm
"Molecular Analysis of the Hypusine Modification on eIF5A"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Structural Biology of (Deoxy)Hypusination"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Roles of the Polyamine-Hypusine Circuit in the Development and Malignant Transformation of B-Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Polyamine Innovations: Food, Microbiota, and Dynamic Enzyme Mechanisms
9:00 am - 9:25 am
"Development of Novel Foods to Increase the Supply of Polyamines"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Microbiota and Polyamines: Crosstalk That Fuels Cancer"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"A Dynamic Dehydrogenase: Progress Toward a Kinetic Mechanism for Carboxyspermidine Dehydrogenase"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Genetically Encoded Fluorescent Sensors for Polyamines"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Roles of Polyamines in Infectious Diseases and Cellular Transport
7:30 pm - 7:55 pm
"Astrocytes on Cleanup Duty: Mopping Up Polyamines for Neural Health"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Advancements in Polyamine Metabolism: Leveraging the DAB-APT Assay to Combat Infectious Diseases, Cancer, and Other Disorders"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Polyamines as Regulators of Immune Responses to Bacterial Infection"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
In Memory of Dr. Patrick Woster and Dr. Autar Mattoo: Polyamine Modulation from Inhibitors to Physiological Adaptations
9:00 am - 9:25 am
"Hypusination and Polyamine-Related Salt Stress Responses of Plants"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Rational Discovery of Inhibitors and Degraders of the Polyamine Deacetylase HDAC10"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Development of Novel Arginine-Polyamine Pathway Inhibitors for the Treatment of ADPKD"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"The Potential of Polyamine Targeted Therapies in Cancer"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Polyamines and Cancer Biology
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
"Targeting Polyamine Dysregulation in Cancer"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"50 Years of Polyamine Gordon Conferences"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure