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Polyamines

Gordon Research Conference

The Role of Polyamines in Health and Disease

July 13 - 18, 2025

Chairs

and

Vice Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Polyamines GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Marking 50 years since the inception of the first GRC on polyamines in 1975, our upcoming 2025 event will uphold the legacy of pioneering research presentations and foster vibrant intellectual exchange. The 2025 conference will focus on recent advances in biomedical research that sheds light on the multifaceted roles of polyamines in orchestrating cellular processes vital for human health and disease. Specifically, the conference will delve into polyamine transport and metabolism across a spectrum of diseases, including cancer, genetic and neurological disorders, and infectious diseases. Additionally, presentations will explore how polyamines influence molecular mechanisms within immunology, microbiome dynamics, bacterial interactions, and overall health, particularly in aging populations. This year’s speakers have been carefully selected to highlight the latest discoveries, including paradigm-shifting findings related to the biological roles of polyamines and their implications for clinical development in disease treatment and prevention.

This GRC will be held in conjunction with the Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Related Meeting

This GRC will be held in conjunction with the "Polyamines" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Polyamines in Immunology Discussion Leader:
7:40 pm - 8:05 pm	"Polyamine Synthesis and Hypusination Prepare Fibroblasts for Collagen Production and Proliferation after Lung Injury"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"The Role of Spermidine in Cancer Immunotherapy and Aging"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Dichotomous Roles of Polyamines in Gastrointestinal Inflammation and Cancer: The Good, the Bad and the Ugly"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Roles of Polyamines in Degenerative Disorders Discussion Leader:
9:00 am - 9:25 am	"Polyamines as Pathogenic Catalysts and Therapeutic Targets in Diabetes"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Transcriptomic Analysis Highlights the Therapeutic Potential of Spermidine in ALS Mouse Models"
10:00 am - 10:10 am	Discussion
10:10 am - 10:35 am	Group Photo / Coffee Break
10:35 am - 11:00 am	"Spermidine: A Path to Better Rest?"
11:00 am - 11:10 am	Discussion
11:10 am - 11:35 am	"ATP13A2 LOSS of Function and Polyamine Deficiency Cause Epigenetic Reprogramming of Astrocytes to an Inflammatory State Toxic to Dopaminergic Neurons"
11:35 am - 11:45 am	Discussion
11:45 am - 12:00 pm	"Spermidine Improves Mitochondrial Quality Restoring Bone Resorption and Differentiation of Osteoclasts in Heteroplasmic Mice and from Patients with Mitochondrial Mutations"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Hypusination and Translation Discussion Leader:
7:30 pm - 7:55 pm	"Molecular Analysis of the Hypusine Modification on eIF5A"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Structural Biology of (Deoxy)Hypusination"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Roles of the Polyamine-Hypusine Circuit in the Development and Malignant Transformation of B-Cells"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Polyamine-Based Therapies and Clinical Trials Discussion Leader:
9:00 am - 9:25 am	"Reading the Signals: Spermidine’s Impact on Autophagy in Humans"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Turning Up the Heat: Reprogramming the Tumor Immune Microenvironment via Polyamine Depletion"
10:00 am - 10:10 am	Discussion
10:10 am - 10:35 am	Coffee Break
10:35 am - 11:00 am	"Polyamines Wobble a Proliferative Switch in Neuroblastoma: Therapeutic Implications"
11:00 am - 11:10 am	Discussion
11:10 am - 11:35 am	"Astrocytes on Cleanup Duty: Mopping Up Polyamines for Neural Health"
11:35 am - 11:45 am	Discussion
11:45 am - 12:00 pm	"Gyrate Atrophy of the Choroid and Retina: A New Polyamine-Related Disorder"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Genetic Disorders and Polyamines Discussion Leader:
7:30 pm - 7:55 pm	"Clinical Aspects of DHPS Deficiency"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Five Years of DFMO Treatment for Bachmann-Bupp Syndrome: Progress, Possibilities and Promise"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"How Spermine Synthase Deficiency Impairs Bone Formation"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Polyamine Innovations: Food, Microbiota, and Dynamic Enzyme Mechanisms Discussion Leader:
9:00 am - 9:25 am	"Development of Novel Foods to Increase the Supply of Polyamines"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Microbiota and Polyamines: Crosstalk That Fuels Cancer"
10:00 am - 10:10 am	Discussion
10:10 am - 10:35 am	Coffee Break
10:35 am - 11:00 am	"A Dynamic Dehydrogenase: Progress Toward a Kinetic Mechanism for Carboxyspermidine Dehydrogenase"
11:00 am - 11:10 am	Discussion
11:10 am - 11:35 am	"Genetically Encoded Fluorescent Sensors for Polyamines"
11:35 am - 11:45 am	Discussion
11:45 am - 12:00 pm	"Exogenous Polyamines Suppress Human T Cell Activation and Mitochondrial Function at the Cervicovaginal Mucosa"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New Roles of Polyamines in Infectious Diseases and Cellular Transport Discussion Leader:
7:30 pm - 7:55 pm	"Novel Drug Targets in Mycobacterium tuberculosis Polyamine Metabolism Essential for Survival in Human Macrophages"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Advancements in Polyamine Metabolism: Leveraging the DAB-APT Assay to Combat Infectious Diseases, Cancer, and Other Disorders"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Defining MRSA Niches in the Kidney"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	In Memory of Dr. Patrick Woster and Dr. Autar Mattoo: Polyamine Modulation from Inhibitors to Physiological Adaptations Discussion Leaders: and
9:00 am - 9:25 am	"Rational Discovery of Inhibitors and Degraders of the Polyamine Deacetylase HDAC10"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Development of Novel Arginine-Polyamine Pathway Inhibitors for the Treatment of ADPKD"
10:00 am - 10:10 am	Discussion
10:10 am - 10:35 am	Coffee Break
10:35 am - 11:00 am	"Clinical and Metabolic Effects of DFMO on Ewing Sarcoma"
11:00 am - 11:10 am	Discussion
11:10 am - 11:35 am	"Hypusination and Polyamine-Related Salt Stress Responses of Plants"
11:35 am - 11:45 am	Discussion
11:45 am - 12:00 pm	"Exploiting BENSpm to Understand New Mechanisms of Action of Polyamines"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Polyamines and Cancer Biology Discussion Leader:
7:30 pm - 7:40 pm	"Inhibition of ODC with DFMO Influences Gut Microbiota and Microbial Metabolites in Autoimmune Diabetes"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"The Interplay of Polyamines, Histone Modifications, and Lifespan Extension Under Methionine Restriction in Yeast"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Targeting ATP13A3-Dependent Polyamine Transport for Cancer Therapy"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 9:00 pm	"Targeting Polyamine Dysregulation in Cancer"
9:00 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"50 Years of Polyamine Gordon Conferences"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Institute for Biology, Chemistry and Pharmacy

Otto and Nicole Phanstiel

Robert Casero and Catherine Hattenburg

Kalin Health

Sigrid C. Roberts

Susan and Neil Gilmour

Michigan State University/Corewell Health International Center for Polyamine Disorders

Conference Links

Conference History Polyamines (GRS)

Registration Fees Additional Fee Info

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