Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
RNA Modifications
Discussion Leader: Nicole Martinez (Stanford University, United States)
7:40 pm - 8:00 pm
Kate Meyer (Duke University, United States)
"M6A-Mediated RNA Regulation at Single-Cell Resolution"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Ryan Flynn (Boston Children's Hospital, United States)
"Cell Surface GlycoRNA Biology"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Yunsun Nam (University of Texas Southwestern Medical Center, United States)
"The Role of RNA Substrate Specificity in Post-Transcriptional Gene Regulation"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Brenda Bass (University of Utah, United States)
"Discriminating Self and Nonself dsRNA during Antiviral Defense"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Mechanisms in Disease
Discussion Leader: Auinash Kalsotra (University of Illinois at Urbana-Champaign, United States)
9:00 am - 9:20 am
Stacy Horner (Duke University, United States)
"Novel Recognition of m6 A in an RNA Virus"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hailing Jin (University of California, Riverside, United States)
"The Warfare of Extracellular RNAs Between Plants and Fungal Pathogens"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sigrid Nachtergaele (Yale University, United States)
"mRNA Stabilization By Chemical Modifications In Drug-Resistant Glioblastoma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Subhashis Natua (University of Illinois, Urbana-Champaign, United States)
"Post-Transcriptional Silencing Of Nuclear Poly(A) Binding Protein Is Critical For Cardiac Maturation And Function."
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stavroula Mili (Center for Cancer Research, National Cancer Institute, NIH, United States)
"Control of Epithelial Tissue Organization by mRNA Localization"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tom Cooper (Baylor College of Medicine, United States)
"Mechanistic Insights of RNA Toxicity and Disrupted RNA Processing from Modeling Myotonic Dystrophy in Mice"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Charlie Moffatt (University of Colorado, Anschutz Medical Campus, United States)
"TDP-43 Inhibits RNA Accumulation in Neurites"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Maureen Akinyi (Baylor College of Medicine, United States)
"QKI Regulated Alternative Splicing Hints At A Novel Mechanism For Enhanced Exon Inclusion"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourโข
The GRC Power Hourโข is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Wendy Gilbert (Yale University, United States) and Eliezer Calo (Massachusetts Institute of Technology, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pre-mRNA Splicing
Discussion Leader: Tracy Johnson (University of California, Los Angeles, United States)
7:30 pm - 7:50 pm
Aaron Hoskins (University of Wisconsin-Madison, United States)
"Mechanisms and Consequences of RNA Duplex Formation during Transcription and Splicing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jimena Giudice (The University of North Carolina at Chapel Hill, United States)
"Alternative Splicing in Muscle Cell Biology and Physiology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Wojciech Galej (EMBL Grenoble, France)
"Structural Studies of Intron Recognition by The Human Spliceosome"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kristen Lynch (University of Pennsylvania, United States)
"Regulation of Innate Immune Signaling by Alternative Splicing"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
RNA Fate
Discussion Leader: David Bentley (University of Colorado School of Medicine, United States)
9:00 am - 9:20 am
Steven West (The Living Systems Institute, University of Exeter, United Kingdom)
"Promoter-Proximal Transcriptional Termination in Mammals"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Torben Heick Jensen (Aarhus University, Denmark)
"Nuclear Sorting of RNA"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Liang Liu (University of California, Irvine, United States)
"A Nuclear RNA Degradation Code For Short, Capped, And Polyadenylated RNAs"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Christine Carroll (Boston University, United States)
"Investigating The Mechanisms Governing Alternative Promoter Usage"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gene-Wei Li (Massachusetts Institute of Technology, United States)
"Sequence Determinants of Bacterial mRNA Stability"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Karen Adelman (Harvard Medical School, United States)
"Transcriptional Control of Stress and Immune Responses"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Michael Cortázar Osorio (University of Colorado Anschutz Medical Campus, United States)
"The communication from mRNA decay to the transcriptional machinery"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Manuel Ares (University of California, Santa Cruz, United States)
"An Ancient Poison Exon with Polyamine-Sensitive Alternative RNA Folding Promotes Homeostatic Control of Polyamine Levels in Vertebrates"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
3'-End Formation
Discussion Leader: Yongsheng Shi (University of California, Irvine, United States)
7:30 pm - 7:50 pm
Liang Tong (Columbia University, United States)
"Structural Insights into RNA 3'-End Processing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Valérie Hilgers (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"The Unique RNA Signatures of The Nervous System: Regulation and Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Athma Pai (UMass Chan Medical School, United States)
"mRNA Initiation and Termination Are Spatially Coordinated"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Bartel (Whitehead Institute / MIT / HHMI, United States)
"Regulation of mRNA Translation and Decay"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Folding
Discussion Leader: Alain Laederach (University of North Carolina at Chapel Hill, United States)
9:00 am - 9:20 am
Sarah Woodson (Johns Hopkins University, United States)
"Co-Transcriptional Assembly of RNA-Protein Complexes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Jessica Brown (University of Notre Dame, United States)
"Elucidating Key Structure-Function Relationships of the METTL16โขMALAT1 Triple Helix Complex"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Bibo Yang (John Innes Centre, United Kingdom)
"Investigating the Functional Roles of RNA Structure in Plants"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Anthony Mustoe (Baylor College of Medicine, United States)
"New Tools for Discovery and Characterization of Complex RNA and RNP Structures"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Maria Hondele (University of Basel, Switzerland, Switzerland)
"DEAD-Box ATPases as Regulators of RNA-Containing Membraneless Organelles"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Philip Bevilacqua (Pennsylvania State University, United States)
"Probing RNA Folding with High-Throughput Approaches: New Tools and Insights into RNA Chemistry and Gene Regulation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kuldeep Sharma (Indian Institute of technology Bombay, India)
"A novel RNA thermosensor element regulating teichoic acid biosynthesis in obligate human pathogen Streptococcus pneumoniae "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Heather Hundley (Indiana University, United States)
"Regulation And Specificity Of dsRNA Binding"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNP Structure and Function
Discussion Leader: Douglas Black (University of California, Los Angeles, United States)
7:30 pm - 7:50 pm
Elena Conti (Max Planck Institute of Biochemistry, Munich, Germany)
"mRNP Configurations Before, Within and Beyond the Nuclear Pore Complex"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Daniel Dominguez (UNC Chapel Hill, United States)
"Protein Disorder and Direct RNA Binding"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Gene Yeo (University of California, San Diego, United States)
"Protein-RNA and Protein-Protein Interactomes to Study RNA Biology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Matthias Hentze (EMBL, Germany)
"Riboregulatioin: Biology, Mechanisms and Scope"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Non-Coding RNAs
Discussion Leader: Jessica Brown (University of Notre Dame, United States)
9:00 am - 9:20 am
Shinichi NAKAGAWA (Hokkaido University, Japan)
"Natural Therapeutic Noncoding RNA 4.5SH : Targeting and Skipping Toxic Exons"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stefania Nicoli (Yale University, United States)
"G3BP1 mRNA Hybrids at Focal Adhesion Proteins Regulate Cell Migration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Zhipeng Lu (USC, United States)
"Decoding The RNA Structurome and Interactome in Living Cells"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Luisa Cochella (Johns Hopkins University, United States)
"Conserved Functions of Deeply Conserved MicroRNAs"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Caitlin Wong Hickernell (University of Chicago, United States)
"Transcriptome-Wide mRNA Condensation Excludes Stress Induced Transcripts"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Alisha Jones (New York University, United States)
"Investigating Cis And Trans Regulatory Factors That Govern Long Noncoding RNA Splicing"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Joshua Mendell (HHMI/The University of Texas Southwestern Medical Center, United States)
"New Functions for Noncoding RNAs in Mammals"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Translation
Discussion Leader: Wendy Gilbert (Yale University, United States)
7:30 pm - 7:50 pm
Eliezer Calo (Massachusetts Institute of Technology, United States)
"tRNA Splicing Defect Underlies Neural Crest Cell Pathologies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Olivia Rissland (University of Colorado School of Medicine, United States)
"The Impact of Coding Regions on Gene Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sebastian Klinge (Rockefeller University, United States)
"Seeing Ribosome Assembly in Action"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Rachel Green (Howard Hughes Medical Institute / Johns Hopkins School of Medicine, United States)
"Concentration Matters: Ribosome Function Beyond Protein Synthesis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure