Sunday |
2:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Posttranslational
Modifications in Cellular Regulation |
| Discussion Leader: Pedro Cutillas (Barts Cancer Institute, Queen Mary University, United Kingdom) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:30 pm | Natalie Ahn (University of Colorado, USA) "New Insights into Regulating MAP Kinase, and Implications for Inhibitor Design" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Peter Quail (University of California, Berkeley, USA) "Dissecting the Phytochrome-PIF Signaling
Interface" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ubiquitination |
| Discussion Leader: Peter Quail (University of California, Berkeley, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Xingwang Deng (Peking University, China) "Ubiquitination and Phosphorylation in COP1-Mediated Light Control of Development" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Joshua Gendron (Yale University, USA) "Inverting Ubiquitin Ligase Function to Study Daily Rhythms of Degradation" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Joshua Baughman (Genentech, Inc., USA) "Proteomic Characterization of Ubiquitin Substrates Unveils New Roles for Ubiquitin in Metabolic Homeostasis" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Group Photo / Coffee Break |
11:15 am - 11:40 am | Namrata Udeshi (Broad Institute of Massachusetts Institute of Technology / Harvard University, USA) "Global Ubiquitylome Profiling for the Identification of Drug Targets in Cancer" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | David Gemperline (University of Wisconsin-Madison, USA) "Defining the Dynamics of the Arabidopsis Ubiquitylome and
SUMOylome" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Elisabeth Stes (VIB - Ghent University, Belgium) "In-Depth Studies of Ubiquitination Targets in Human and Plant Cell Cultures" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The O-GlcNAc Modification |
| Discussion Leader: Natalie Ahn (University of Colorado, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Xiaoyong Yang (Yale University School of Medicine, USA) "Cracking the O-GlcNAc Code in Cellular Regulation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Hong Zhang (Chinese Academy of Sciences, China) "O-GlcNAc Modification of SNAP29 Controls Autophagosome Maturation" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Samuel Myers (Broad Institute of Massachusetts Institute of Technology / Harvard University, USA) "O-GlcNAc Regulates SOX2 Function in Pluripotent Stem Cells" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Yanping Zhu (Simon Fraser University, Canada) "Post-Translational O-GlcNAcylation Is Essential for Nuclear Pore Integrity and Maintenance of the Pore Selectivity Filter" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Phosphorylation and Signaling |
| Discussion Leader: Barbara Panning (University of California, San Francisco, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Chentao Lin (University of California, Los Angeles, USA) "Blue Light-Dependent Phosphorylation of Cryptochromes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Pedro Cutillas (Barts Cancer Institute, Queen Mary University, United Kingdom) "Systematic Identification of Regulatory Kinases in Growth Factor Signaling Networks" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Miyoshi Haruta (University of Wisconsin-Madison, USA) "Interaction of a Peptide Hormone, RALF (Rapid
Alkalinizing Factor), with the Receptor-Like Protein Kinase,
Feronia, Rapidly Inhibits the Plasma Membrane Proton Pump and Cell Elongation
in Plants" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Ning Li (The Hong Kong University of Science and Technology, Hong Kong SAR China) "Application of Quantitative Proteomics in Study of Ethylene Signaling" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Hong Qiao (University of Texas at Austin, USA) "Ethylene-Dependent Protein Phosphorylation in Plant Growth" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Subbareddy Maddika (Centre for DNA Fingerprinting and Diagnostics (CDFD), India) "Mapping the Functional Human Protein Phosphatase Network" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Functions of Diverse PTMs |
| Discussion Leader: Lan Huang (University of California, Irvine, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Pedro Beltrao (European Molecular Biology Laboratory, European Bioinformatics Institute, United Kingdom) "Function and Evolution of Protein Post-Translational Modifications" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Jyoti Choudhary (Sanger Institute, United Kingdom) "Characterisation of the Palmitome Using Quantitative Mass Spectrometry" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Thomas Arnesen (University of Bergen, Norway) "Protein N-Terminal Acetylation: From Acetylation Machinery to Human Disease" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Yonghao Yu (University of Texas Southwestern Medical Center, USA) "Large-Scale Identification
of Cell-Specific PARP Substrates" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Xiaohu Ren (Shenzhen Center for Disease Control and Prevention, China) "Studies of SET-Mediated Protein Phosphorylation
and Nucleolin Self-Regulatory in Trichloroethylene-Induced Hepatic Cytotoxicity" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PTM Crosstalk and Networks |
| Discussion Leader: Heribert Hirt (King Abdullah University of Science and Technology, Saudi Arabia) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Anne-Claude Gingras (Lunenfeld-Tanenbaum Research Institute, Canada) "Phosphatases and Kinases Dance a Tango" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Steven Huber (Agricultural Research Service, US Department of Agriculture / University of Illinois, USA) "Potential for Multiple Modifications of Metabolic Enzymes and Receptor Kinases" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Waltraud Schulze (University of Hohenheim, Germany) "Dynamic Interaction Networks of Receptor Kinase Complexes" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Steven Briggs (University of California, San Diego, USA) "Reconstruction of an Enzyme-Substrate Network from the Kinome of Maize" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Juan Dong (Rutgers University, USA) "Phospho-Status of BASL Regulates Polar Trafficking and Coordinates Cell Fates During Stomatal Asymmetric Division in Arabidopsis" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Hongbo Luo (Harvard Medical School / Children's Hospital Boston, USA) "Cysteine S-Glutathionylation Protects Cytokine from
Reactive Oxidative Species (ROS)-Induced Deactivation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Cell Regulatory Networks |
| Discussion Leader: Ning Li (The Hong Kong University of Science and Technology, Hong Kong SAR China) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Wolfram Weckwerth (University of Vienna, Austria) "Complex Integration of Metabolomics, Proteomics and Phosphoproteomics with Metabolic Modelling Reveals Systemic Relationships in Biochemical Signalling Networks" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | W. Andy Tao (Purdue University, USA) "Protein Phosphorylation in ABA and Environmental Stress
Signaling in Plants" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Yu-Ju Chen (Institue of Chemistry, Academia Sinica, Taiwan) "Large-Scale Measurement of Phosphorylation Stoichiometry in Human Cells" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Qian Zhao (University of California, San Francisco, USA) "Irreversible Lysine-Targeting Kinase Probes for In Situ Kinase Inhibitor Selectivity Profiling by Chemical Proteomics" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PTMs in Disease and Immunity |
| Discussion Leader: Anne-Claude Gingras (Lunenfeld-Tanenbaum Research Institute, Canada) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Feng Shao (National Institute of Biological Sciences, China) "Pathogen-Mediated New Posttranslational Modifications of Host Innate Immune System" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Yiji Xia (Hong Kong Baptist University, Hong Kong SAR China) "Redox Signaling Mediated by a Redox-Sensitive bZIP Transcription Factor in Arabidopsis" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Frank Menke (Sainsbury Laboratory, United Kingdom) "Targeting Post Translational Modifications in Plant Immunity Signaling" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Junmin Peng (St. Jude Children's Research Hospital, USA) "Systems Approaches to Drug Resistance Mechanism in Multiple Myeloma" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Boris Macek (University of Tuebingen, Germany) "Impact of Individual Single Nucleotide Variants on Signal Transduction Networks in Cancer" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Zan Chen (Johns Hopkins University School of Medicine, USA) "Interplay of Phosphorylation and Ubiquitination to Regulate PTEN Activity" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Chromatin Modifications and Epigenetics |
| Discussion Leader: Steven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA) |
4:00 pm - 4:10 pm | Introduction by Discussion Leader |
4:10 pm - 4:35 pm | Barbara Panning (University of California, San Francisco, USA) "A Sweet Story About Stem Cells" |
4:35 pm - 4:45 pm | Discussion |
4:45 pm - 5:10 pm | Yingming Zhao (The University of Chicago, USA) "Epigenetic and Metabolic Regulation by a Family of New Lysine Acylation" |
5:10 pm - 5:20 pm | Discussion |
5:20 pm - 5:50 pm | Steven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA) "Epigenetic Gene Regulation in Arabidopsis" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |