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Lipids, Molecular & Cellular Biology of
Gordon Research Conference

Lipids in Signaling and Metabolism

Dates

July 30 - August 4, 2017

Location

Waterville Valley
Waterville Valley, NH Site Information

Organizers

Chair:
David A. Bernlohr

Vice Chair:
Todd R. Graham

Application Deadline

Applications for this meeting must be submitted by July 2, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Research Conference (GRC) on Molecular and Cellular Biology of Lipids brings together leading scientists in the lipid field to present and discuss their research and to facilitate research advances. This Lipids GRC has been held every other year for almost 50 years and is internationally recognized as the major forum for the presentation of ground breaking and innovative research in prokaryotic and eukaryotic lipid biochemistry, signaling and regulation of gene expression. In 2017, the Conference will focus heavily on the continuing emergence of lipids in the underlying mechanisms linked to the development of chronic diseases like obesity, hepatic steatosis, cardiomyopathy, atherosclerosis, and diabetes. Innovations include the selection of a) speakers who are new to this conference and international conference, b) novel topics that have not previously received attention, c) enhanced opportunities for junior and senior investigators to engage in scientific discussion and d) expanded poster session and opportunities to give short "late-breaking" talks. New topics include autophagy, signal transduction and gene expression, the microbiome, lipid droplet biology, and lipid microdomains. A continuing innovation within the Lipids GRC is the speakers' lunch where we set aside specific tables where junior participants can meet the speakers for lunch. Keynote speakers have been chosen for their excellence, expertise and engagement and will kick off the meeting with an evening session followed by a social mixer. The intimate atmosphere of the meeting is limited to ~150 participants which enables attending scientists to interact closely with each other. The resulting discussions drive future advances and multidisciplinary collaborations in the field. Participants and speakers have been and will be chosen to reflect international excellence in this medically relevant area of science, with an ideal balance between youth and experience. The program includes outstanding women and men, and scientists of different ethnicities and nationalities. Facilities are available to accommodate handicapped individuals and the site has numerous activities for children so as to encourage attendance by families.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Lipids in Signaling and Metabolism
Discussion Leader: David Bernlohr (University of Minnesota, Twin Cities, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmRosalind Coleman (University of North Carolina at Chapel Hill, USA)
"Compartmentalizing Lipid Metabolism"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pmJean Schaffer (Washington University in St. Louis, USA)
"RNA Regulation of Lipotoxicity"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Intracellular Lipid Storage and Utilization
Discussion Leader: Judith Storch (Rutgers University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amBrian Finck (Washington University in St. Louis, USA)
"Convergent Pathways of Diacylglycerol Synthesis or Only the Tip of the Iceberg?"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amShort Talk Selected from Poster Abstracts
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amGroup Photo / Coffee Break
10:40 am - 11:15 amDawn Brasaemle (Rutgers University, USA)
"Investigating the Function of CGI-58, an Enigmatic Protein"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amShort Talk Selected from Poster Abstracts
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmDouglas Mashek (University of Minnesota, USA)
"ACOT1: A Regulatory Node in Fatty Acid Signaling and Metabolism"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAutophagy and Lipid Metabolism
Discussion Leader: Jean Schaffer (Washington University in St. Louis, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:15 pmMartin Graef (Max Planck Institute for Biology of Aging, Germany)
"Acyl-CoA Synthetases Drive Autophagy"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmShort Talk Selected from Poster Abstracts
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmJennifer Lippincott-Schwartz (National Institutes of Health, USA)
"Dissecting the Mechanism for Micro-Lipophagy in Yeast and Its Role in Lifespan Extension Under Starvation"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Lipid Trafficking
Discussion Leader: Rosalind Coleman (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amSilvana Zanlungo (Pontificia Universidad Catolica de Chile, Chile)
"Pathogenic Mechanisms in Niemann-Pick Type C Cholesterol Storage Disease"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amShort Talk Selected from Poster Abstracts
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:15 amJudith Storch (Rutgers University, USA)
"Cholesterol Trafficking in Niemann-Pick C Disease"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amShort Talk Selected from Poster Abstracts
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmJessica Ellis (Purdue University, USA)
"Fatty Acid Oxidation Is Required for the Working Heart: Lessons from Cardiac CPT2 Deficiency"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Microbiome and Lipid Metabolism
Discussion Leader: Douglas Mashek (University of Minnesota, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:15 pmM. Stephen Trent (University of Georgia, USA)
"The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmShort Talk Selected from Poster Abstracts
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmLate-Breaking Topic
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMembrane Microdomains: Structure and Function
Discussion Leader: Dawn Brasaemle (Rutgers University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amMary Kraft (University of Illinois at Urbana-Champaign, USA)
"Does the Influenza Virus Bud from Membrane Domains Enriched with Cholesterol and Sphingolipids?"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amShort Talk Selected from Poster Abstracts
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:15 amLate-Breaking Topic
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amShort Talk Selected from Poster Abstracts
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmPaul Pilch (Boston University, USA)
"Lessons Learned from the Caveolin-Cavin System"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation and Function of Phospholipid Metabolism
Discussion Leader: Todd Graham (Vanderbilt University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:15 pmSteven Claypool (Johns Hopkins University, USA)
"Rewiring Mitochondrial Phosphatidylethanolamine Metabolism in Yeast"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmShort Talk Selected from Poster Abstracts
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmNihal Altan-Bonnet (National Institutes of Health, USA)
"Viral Propagation in Vesicles: Pooped out or Pathogenic?"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmLipid-Mediated Signal Transduction
Discussion Leader: Brian Finck (Washington University in St. Louis, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:45 amHeather Bradshaw (Indiana University, USA)
"Lipoamines: An Emerging Class of Novel Lipid Signaling Molecules"
9:45 am - 9:55 amDiscussion
9:55 am - 10:05 amShort Talk Selected from Poster Abstracts
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:15 amGeorge Carman (Rutgers University, USA)
"Phosphatidic Acid Phosphatase Regulates Phospholipid Synthesis via Phosphatidylserine Synthase"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amShort Talk Selected from Poster Abstracts
11:35 am - 11:40 amDiscussion
11:40 am - 12:15 pmNils Faergeman (University of Southern Denmark, Denmark)
"Regulation of De Novo Sphingolipid Synthesis by Directional Acyl-CoA Channeling"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTranscriptional Control in Lipid Metabolism
Discussion Leader: Nils Faergeman (University of Southern Denmark, Denmark)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 6:15 pmSoonkyu Chung (University of Nebraska, USA)
"Dietary n-3 PUFA Increases Brown Adipogenesis Through miRNA-Associated Mechanisms"
6:15 pm - 6:25 pmDiscussion
6:25 pm - 6:35 pmShort Talk Selected from Poster Abstracts
6:35 pm - 6:40 pmDiscussion
6:40 pm - 7:15 pmTimothy Osborne (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Setting the Stage for SREBP Dependent Regulation of Hepatic Lipid Metabolism"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:30 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK 113751-01 from the National Institute of Diabetes and Digestive and Kidney Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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