Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Structure and Dynamics |
| Discussion Leader: Elspeth Garman (University of Oxford, United Kingdom) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:30 pm | Carrie Wilmot (University of Minnesota, USA) "MauG Catalysis: A Tale of Ferryl Heme, Radicals and Long-Distance Hopping" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Joseph Ferrara (Rigaku Americas Corporation, USA) "Forty Years of Diffraction Methods - A Personal Narrative" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | New Instruments and Opportunities |
| Discussion Leader: Robert Sweet (National Synchrotron Light Source II, Brookhaven National Laboratory, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Armin Wagner (Diamond Light Source, United Kingdom) "In-Vacuum Long-Wavelength Crystallography – First Results" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Matthew Bowler (Synchrotron Crystallography Team, European Molecular Biology Laboratory, France) "Fully Automatic Characterisation and Data Collection: A New Tool for Structural Biologists" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Marjolein Thunnissen (MAX IV Laboratory, Lund University, Sweden) "Possibilities for Structural and Dynamical Studies on Proteins at MAX IV" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | William Graves (Arizona State University, USA) "Electron Diffraction as a Method to Produce a Tabletop XFEL" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Emil Pai (University of Toronto, Canada) "There Is Nothing Like High Resolution –
Surprising Features in an Enzyme's Mechanism" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Oliver Smart (PDBe, European Bioinformatics Institute, United Kingdom) "PDB Structure Validation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Improving Maps and Models |
| Discussion Leader: Airlie McCoy (University of Cambridge, United Kingdom) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Elspeth Garman (University of Oxford, United Kingdom) "Unambiguous Metal Identification and Accurate Stoichiometric Measurements in Proteins" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Frank Von Delft (Structural Genomics Consortium, United Kingdom) "PANDDA: A Multi-Dataset Method for Electron Density Signal Extraction of Superposed States such as Low-Occupancy Ligands" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | James Fraser (University of California, San Francisco, USA) "Birth of the Cool:
Multitemperature X-Ray Crystallography to Reveal Protein Conformational
Heterogeneity" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Paul Adams (Lawrence Berkeley National Laboratory, USA) "New Tools for Interpretation of Cryo-EM Maps" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structural Biology Requires Multiple Methods |
| Discussion Leader: Nozomi Ando (Princeton University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Allison Edwards (Bragg Institute, Australian Nuclear Science and Technology Organisation, Australia) "Neutron Diffraction Studies – Making Best Use of the Available Data" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Neil Ranson (University of Leeds, United Kingdom) "Experiences and Results Using the New Direct Electron Detectors for CryoEM" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Saikrishnan Kayarat (Indian Institute of Science Education and Research, Pune, India) "Mechanism of a Motor-Driven Endonuclease: Combining Structural and Single-Molecule Approaches" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Nikolai Skrynnikov (Purdue University, USA) "Motions of Protein Molecules Within the Crystalline Lattice" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Sarah Bowman (Massachusetts Institute of Technology, USA) "What Can Spectroscopic Techniques Tell You About Your Crystal" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Dynamically Resolved Methods |
| Discussion Leader: Carrie Wilmot (University of Minnesota, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Thomas Barends (Max-Planck Institute for Medical Research, Germany) "Ultrafast Functional Motions in Myoglobin Probed
by Serial Femtosecond Crystallography" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Gergely Katona (University of Gothenburg, Sweden) "An Interleaved Data Recording Method for Studying the Non-Thermal Effect of Terahertz Radiation on Protein Crystals" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Kanupriya Pande (Center for Free-Electron Laser Science, Germany) "Femtosecond Structural Dynamics in Photoactive
Yellow Protein" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Petra Fromme (Arizona State University, USA) "Time-Resolved Femtosecond Crystallography: Towards Molecular Movies of Biomolecules 'In Action'" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hybridization of Synchrotron and XFEL Approaches |
| Discussion Leader: Christine Gee (Howard Hughes Medical Institute / University of California, Berkeley, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Nadia Zatsepin (Arizona State University, USA) "Making the Most out of XFELs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Manfred Burghammer (European Synchrotron Radiation Facility, France) "Recent Developments in Serial Micro-/Nano-Beam Diffraction X-Ray Techniques at ID13, ESRF" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Helen Ginn (University of Oxford, United Kingdom) "Development of Methods in
XFEL Analysis" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Thomas White (Center for Free-Electron Laser Science, Germany) "Advances in Data Processing for Serial Femtosecond Crystallography" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Allen Orville (Diamond Light Source, United Kingdom) "Dynamic Structural Biology: Awakened and Enabled by New Sources and Complementary Methods" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Developments in Diffraction Methods |
| Discussion Leader: Clyde Smith (Stanford University, USA) |
7:30 pm - 8:00 pm | Isabel Uson (ICREA, Spanish National Research Council, Spain) "Local Folds and Fragments in Phasing, Autotracing and Structure Interpretation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kartik Ayyer (DESY, Germany) "Coherent Diffractive Imaging as a Structure Determination Tool for Disordered Crystals" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Andrea Thorn (MRC Laboratory of Molecular Biology, United Kingdom) "Developments in Diffraction Data Analysis" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Selected Poster Presentations: New Cool Methods and Hot New Structures |
| Discussion Leader: James Fraser (University of California, San Francisco, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:20 am | Selected from Poster Abstracts: Johan Hattne (Howard Hughes Medical Institute, USA) "Recent Developments in MicroED" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Selected from Poster Abstracts: Bradley Hintze (Duke University, USA) "Topal-Fresco DNA Base Pairs in the PDB and Lessons in Low Frequency Observations" |
9:40 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Selected from Poster Abstracts: Brian Kelch (University of Massachusetts Medical School, USA) "A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:50 am | Selected from Poster Abstracts: Sarah Perry (University of Massachusetts, Amherst, USA) "Time Resolved Serial Protein Crystallography in Ultra-Thin Microfluidic Devices" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Selected from Poster Abstracts: Katharina Brunner (Karolinska Institutet, Sweden) "Cysteine Synthase Inhibitors with Antibacterial Potency Against Dormant Mycobacterium Tuberculosis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Selected from Poster Abstracts: Ho Leung Ng (University of Hawaii, Manoa, USA) "Seeing the Invisible: Hydrogen Atoms in X-Ray Crystallography Maps" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Selected from Poster Abstracts: Swagatha Ghosh (Institute of Stem Cell Biology and Regenerative Medicine, India) "A Blue Protein with Red Fluorescence" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Selected from Poster Abstracts: Mitchell Miller (Rice University, USA) "Results from the Direct Phasing of Protein Structures with High Solvent Contents" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Nicole Scarborough (Purdue University, USA) "Dynamic X-ray Diffraction Sampling for Automated Protein Crystal Positioning" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structural and Dynamical Information Beyond Bragg |
| Discussion Leader: James Holton (Advanced Light Source, Lawrence Berkeley National Laboratory, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Michael Wall (Los Alamos National Laboratory, USA) "Probing Protein Structural Dynamics Using Diffuse X-Ray Scattering" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Robert Rambo (Diamond Light Source, United Kingdom) "A Real-Space Modelling Algorithm for SAXS Using Information Theory and Computational Geometry" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Nozomi Ando (Princeton University, USA) "Untangling Protein Allostery" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |