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Spirochetes, Biology of
Gordon Research Conference

Spirochete Biology in the Host and in the Wild

Dates

January 21-26, 2018

Location

Ventura Beach Marriott
Ventura, CA Site Information

Organizers

Chair:
Jenifer L. Coburn

Vice Chair:
Scott Samuels

Application Deadline

Applications for this meeting must be submitted by December 24, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Spirochetes constitute a deeply-branching phylum of bacteria originally defined by their helical or sinusoidal shape, double membrane ultrastructure, and periplasmic flagella. The agents of Lyme disease, syphilis, leptospirosis, relapsing fever, periodontal disease, and intestinal spirochetosis pose enormous and growing global threats to human and animal health. Pathogenic spirochetes are renowned for their ability to rapidly disseminate and cause extensive tissue damage by eliciting inflammatory responses, and to establish persistent infection. To reflect the diversity of research in the spirochete world, the 2018 BoS GRC has an exciting program that will cover topics from fundamental aspects to the research frontiers of spirochete biology. The conference will include presentations on ecology, evolution, epidemiology, genomics, pathogenic mechanisms/virulence attributes, and the role of the host immune response in clearance and in pathogenesis.

For consideration for oral presentation of poster abstracts (poster talks), please complete your application by October 31, 2017.

Related Meeting

This GRC will be held in conjunction with the "Spirochetes, Biology of" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Gordon Research Conferences
Medical College of Wisconsin
Immuno Technologies, Inc.
Merial
Global Lyme Alliance
New England BioLabs, Inc.
Sanofi
Gilead Sciences

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Spirochete Biology: Insights and Vistas
Discussion Leader: Patricia Rosa (National Institute of Allergy and Infectious Diseases, NIH, USA)
7:40 pm - 8:20 pmTom Schwan (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Divergent Adaptations by Spirochetes Transmitted by Fast and Slow Feeding Ticks: Why Relapsing Fever Spirochetes Are So Special!"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmSheila Lukehart (University of Washington, USA)
"Syphilis – What a Way to Make a Living!?!"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFundamentals of Spirochete Biology
Discussion Leader: Ben Adler (Monash University, Australia)
9:00 am - 9:30 amJustin Radolf (UConn Health, USA)
"The Treponema pallidum Outer Membrane: 30+ Years Trying to Figure Out What Is Out There"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amMichael Matthias (University of California, San Diego, USA)
"Leptospira Comparative Genomics"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amDarrin Akins (University of Oklahoma Health Sciences Center, USA)
"Outer Membrane Biogenesis Requires a Unique Protein Export System in B. burgdorferi"
10:30 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:20 amFrank Yang (Indiana University School of Medicine, USA)
"Two Dinucleotide Second Messengers Control Adaptation to Each Host During the Enzootic Cycle of Borrelia burgdorferi"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amLorenzo Giacani (University of Washington, USA)
"Regulation of Gene Expression in Treponema pallidum by Poly-G Repeats"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmNyles Charon (West Virginia University, USA)
"The Hook Protein of Spirochetes Is a Covalent Cross-Linking Machine"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sheila Lukehart (University of Washington, USA) and Catherine Brissette (University of North Dakota School of Medicine and Health Sciences, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBacterial-Host Interactions: Virulence Attributes
Discussion Leader: Mathieu Picardeau (Institut Pasteur, France)
7:30 pm - 7:50 pmKaren Lithgow (University of Victoria, Canada)
"Interactions of the Treponema pallidum Adhesin Tp0751 with the Host Vascular Endothelium"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDavid Haake (VA Greater Los Angeles Healthcare System / University of California, Los Angeles, USA)
"Virulence Proteins of Pathogenic Leptospira Species"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmSven Bergstrom (Umea University, Sweden)
"Infection Biology of RF Borrelia – Impact of Erythrocyte Rosetting During Infection"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEcology and Epidemiology
Discussion Leader: Paul Mead (Centers for Disease Control and Prevention, USA)
9:00 am - 9:20 amClaudia Munoz-Zanzi (University of Minnesota, USA)
"Ecological, Social, and Epidemiological Elements of Leptospirosis Transmission at Varying Scales"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amOriol Mitja (Barcelona Institute for Global Health, Spain)
"Assessment of Mass Azithromycin Treatment for Yaws Using Epidemiological and Molecular Approaches"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSascha Knauf (German Primate Center, Germany)
"One Health: The Relationship of Simian and Human Treponemes"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amJean Tsao (Michigan State University, USA)
"Geographic Variation in the Risk of Lyme Disease in the Eastern U.S: How Ecology Matters"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amConnie Gebhart (University of Minnesota, USA)
"Veterinary Brachyspiras: Old and New"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmGeorgies Mgode (Sokoine University of Agriculture, Tanzania)
"Leptospirosis Burden in Africa with Recent Updates from Tanzania"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBacterial-Host Interactions: Explorations
Discussion Leader: Annette Moter (Biofilm Center, Deutsches Herzzentrum Berlin (DHZB), Germany)
7:30 pm - 7:50 pmJared Leadbetter (California Institute of Technology, USA)
"New Insights into the Symbiosis Between Termite Gut Spirochetes and Their Insect Hosts"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAngela Barbosa (Instituto Butantan, Brazil)
"The Role of Thermolysins in Leptospira Pathogenesis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmJon Skare (Texas A&M Health Science Center, USA)
"Assigning a Role to Proteins of Unknown Function in Borrelia burgdorferi"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSpirochetes vs. Host Defenses and Responses
Discussion Leader: Nicole Baumgarth (University of California, Davis, USA)
9:00 am - 9:20 amCatherine Werts (Institut Pasteur, France)
"Escape of TLR5 Recognition by Pathogenic Leptospira: A Rationale for Endoflagella"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJuan Salazar (Connecticut Children's Medical Center, USA)
"The Role of the Macrophage in Spirochetal Recognition and Clearance"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMichelle Visser (State University of New York at Buffalo, USA)
"Modulation of Neutrophil Response by Treponema denticola Virulence Factors"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amRicardo Gomez (Instituto de Biotecnología y Biología Molecular, CONICET-UNLP, Argentina)
"Acute and Chronic Murine Response to Leptospira Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amStuart Carter (University of Liverpool, United Kingdom)
"Treponemes Causing Digital Dermatitis in Cattle Are Now Emerging in New Diseases on Farms and in the Wild"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmRobert Lochhead (Massachusetts General Hospital / Harvard Medical School, USA)
"MicroRNAs and Host Response in Lyme Arthritis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEmergence and Evolution
Discussion Leader: Dustin Brisson (University of Pennsylvania, USA)
7:30 pm - 7:50 pmNataliia Rudenko (Institute of Parasitology Biology Centre, Czech Academy of Sciences, Czech Republic)
"Impact of Genome Variations and Host Association on Emergence and Evolution of Lyme Disease Spirochetes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAlan Barbour (University of California, Irvine, USA)
"Evolution of Antigenic Variation in Borrelia"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmNatasha Arora (Institute of Forensic Medicine, University of Zurich, Switzerland)
"Genomic Approaches to Understanding the Origins of Syphilis and Its Re-Emergence"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDissemination and Persistence
Discussion Leader: Catherine Brissette (University of North Dakota School of Medicine and Health Sciences, USA)
9:00 am - 9:20 amLinda Bockenstedt (Yale School of Medicine, USA)
"Multidimensional Modeling of the Immune Response to Borrelia burgdorferi in Humans"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJarlath Nally (National Animal Disease Center, USDA, USA)
"The Ins and Outs of Persistent Renal Excretion of Leptospires"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amShort Talk Selected from Poster Abstracts
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amJohn Belisle (Colorado State University, USA)
"Defining the Presentations of Lyme Disease Through Small Molecule Metabolism"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amShort Talk Selected from Poster Abstracts
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmArnau Casanovas-Massana (Yale School of Public Health, USA)
"Mechanisms of Survival of Pathogenic Leptospira in Soil and Water"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrontiers in Spirochete Research: The Next Big Questions
Discussion Leaders: Brandon Jutras (Howard Hughes Medical Institute / Yale University, USA) and Helena Petrosova (University of Victoria, Canada)
7:30 pm - 8:00 pmSteven Norris (University of Texas Health Science Center at Houston, USA)
"Putting It All Together: Spirochetal Biology in the Post-Hypothetical Era"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJanis Weis (University of Utah, USA)
"Multiple Inflammatory Pathways Can Lead to Lyme Arthritis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAlbert Ko (Yale School of Public Health, USA)
"Leptospirosis Trek: Going Where No One Has Gone Before"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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