Sunday evening (1/30/00)
(7:30 pm - 9:00 pm) | Keynote Presentation |
Li-yuan Yu-Lee (Chair) and Carlyle Storm (GRC Director)-- Welcoming remarks
- George Stark, Cleveland Clinic Foundation, Cleveland
"STAT1 as a tumor suppressor: Role of STAT1-dependent, interferon-independent transcription and interferon-dependent, STAT1-independent signaling"
Monday morning (1/31/00)
(8:30 am - 12:30 pm) | Pituitary Development and PRL Secretion |
Chair: Priscilla Dannies, Yale University, New Haven
- Shlomo Melmed, Cedar-Sinai Medical Center, Los Angeles
"Cytokine-mediated pituitary development"
- Nira Ben-Jonathan, University of Cincinnati, Cincinnati
"Pituitary estrogen receptors, environmental estrogens and PRL"
- Shuji Hinuma, Takeda Chemical Industries, Japan
"Prolactin releasing peptide identified by utilizing orphan receptor"
- David Wynick, University of Bristol, Bristol, United Kingdom
"Galanin regulation of lactotrophe function"
Two 10 min platform talks (Chair: Paul Kelly, INSERM, Paris)
- Stephanie Bessone, INSERM, Nice, France
"EMK protein kinase null mice: dwarfism, hypofertility and low anxiety associated with alterations in somatotrope and PRL pathways"
- Purushothama Gowri, U. Kentucky, Lexington
"Threonine-757 of signal transducer and activator of transcription 5 (Thr-Stat5) regulates Na/taurocholate cotransporter polypeptide (NCTP) transactivation potential"
Monday afternoon (1/31/00)
(4:00 pm - 6:00 pm) | Poster Session I |
Monday evening (1/31/00)
(7:30 pm - 9:30 pm) | Regulation, Expression and Signaling of PRL |
Chair: Nelson Horseman, University of Cincinnati, Cincinnati
- Arthur Gutierrez-Hartmann, University Colorado, Denver
"Isoform-specific transcription switch motifs in Pit-1 and Ets nuclear factors differentially regulate prolactin promoter activity"
- Charles Clevenger, University of Pennsylvania, Philadelphia
"Novel mechanism of PRL signaling"
- Sue Hankinson, Harvard University, Boston
"Plasma PRL levels and subsequent breast cancer risk in postmenopausal women"
Tuesday morning (2/1/00)
(8:30 am - 12:30 pm) | GH and PRL Receptor Signaling |
Chair: Susan Berry, University of Minnesota, Minneapolis
- Christin Carter-Su, University of Michigan, Ann Arbor
"SH2B and SIRP, Jak2 binding proteins that modulate actions of GH"
- Joelle Finidori, INSERM, Paris, France
"GH receptor associated proteins involved in the regulation of GH signaling"
- John Kopchick, Ohio University, Athens
"GH antagonist transgenic and GH receptor gene disrupted mice - mechanisms of GH action in vivo"
- Warren Alexander, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
"SOCS proteins - negative regulators of Jak/Stat signaling"
Two 10 min platform talks (Chair: Paul Kelly, INSERM, Paris)
- Asael Herman, Hebrew U., Rehovot, Israel
"Functional heterodimerization of PRL and GH receptors by ovine PL"
- Missy Book McAlexander, Baylor College of Medicine, Houston
"PRL signaling to the IRF-1 gene: transcriptional regulation and chromatin remodeling"
| Tuesday afternoon (2/1/00) | Workshop on Hormone Nomenclature |
Discussion leaders: Dan Linzer, Northwestern U., Chicago and Michael Soares, U. Kansas, Kansas City
Tuesday evening (2/1/00)
(7:30 pm - 9:30 pm) | Transcriptional Controls |
Chair: David Waxman, Boston University, Boston
- Warren Leonard, National Institutes of Health, Bethesda
"The significance of Stat5 tetramerization in gene regulation"
- Jennifer Richer, University of Colorado, Denver
"Progesterone primes breast cancer cells for cytokine and growth factor mediated signals"
- Ameae Walker, University of California, Riverside
"Dissocation of Jak2 and Stat5 activation after engagement of the PRL-R by a molecular mimic of phosphorylated PRL"
Wednesday morning (2/2/00)
(8:30 am - 12:30 pm) | PRL on Mammary Gland |
Chair: Bernd Groner, Georg-Speyer-Haus Institute, Frankfurt, Germany
- Nancy Hynes, Friedrich-Minsch Research Institute, Basel, Switzerland
"Receptor tyrosine kinases and Stats in the mammary gland"
- Lothar Hennighausen, National Institutes of Health, Bethesda
"Hormone-controlled mammary development and tumorigenesis: the contributions of Stats and Brca-1"
- Jeff Rosen, Baylor College of Medicine, Houston
"Composite hormone response elements integrate steroid and peptide hormone receptor signal transduction pathways"
- Christine Watson, University of Cambridge, Cambridge, United Kingdom
"A conditional gene targeting approach to Jak/STAT function in mammary gland"
Two 10 min platform talks (Chair: Paul Kelly, INSERM, Paris)
- Chris Ormandy, Garvan Institute of Medical Research, Sydney, Australia
"PRL acts exclusively via the mammary epithelium to direct mammary development during pregnancy"
- Marja Navalainen, Uniformed Services U. Health Sciences, Bethesda
"PRL is a survival factor for androgen-deprived rat dorsal and lateral prostate epithelium in organ culture"
Wednesday afternoon (2/2/00)
(4:00 pm - 6:00 pm) | Poster Session II |
| Wednesday evening (2/2/00) (7:30 pm - 9:30 pm) | PRL on Immune Diseases |
Chair: Susan Richards, Genzyme Corporation, Boston
- Betty Diamond, Albert Einstein College of Medicine, New York
"Estrogen effects on B cell fate"
- Dennis Taub, National Institutes of Health, Baltimore
"The immunoregulatory effects of PRL and GH on T cell effector functions"
- Steve Anderson, University of Colorado, Denver
"Anti-apoptosis signaling by the PRL receptor"
Thursday morning (2/3/00)
(8:30 am - 12:30 pm) | PRL on the Utero-Placental Unit |
Chair: Geula Gibori, University of Chicago, Chicago
- Mike Soares, University of Kansas, Kansas City
"Uteroplacental PRL family: immunological regulators of viviparity?"
- Daniel Linzer, Northwestern University, Chicago
"Placental PRL: Biology of pregnancy"
- Yvonne Pohnke, University of Hamburg, Hamburg, Germany
"C/EBPs and control of decidual PRL expression"
Two 10 min platform talks (Chair: Paul Kelly, INSERM, Paris)
- Tom Spencer, Texas A & M U. College Station
"Lactogenic and somatogenic hormones in ovine uterine morphogenesis and function"
- Cecilia Santos, U. Algarce, Faro, Portugal
"Expression of PRL-R in sea bream (Sparus aurata) adult tissues and during the early stages of development"
Thursday evening (2/3/00)
(7:30 pm - 9:30 pm) | PRL and GH on Angiogenesis and Apoptosis |
Chair: Richard Weiner, University of California, San Francisco
- Priscilla Furth, University of Maryland, Baltimore
"Prolactin signaling pathways and regulation of apoptosis during mammary gland involution"
- Carmen Clapp, U. Mexico, Mexico City, Mexico
"Endothelial-derived PRL"
- Joseph Martial, University of Liege, Liege, Belgium
"Anti-angiogenic effects of 16 K lactogenic hormones"
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