| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Presentation |
| 3:45 pm - 4:15 pm | Matthias Rief (Technical University of Munich)
"Single molecule dynamics of proteins under load"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Protein folding dynamics at the single molecule level |
| Discussion Leaders: Matthias Rief (Technical University of Munich) and Peng Zheng (University of British Columbia)
|
| 7:30 pm - 7:46 pm | Mehdi Damaghi (ETH Zurich)
"Folding mechansim of a beta barrel protein in the membrane"
|
| 7:46 pm - 7:54 pm | Discussion |
| 7:54 pm - 8:10 pm | Armin Hoffmann (University of Alberta)
"Folding dynamics from single-molecule trajectories using signal-pair correlation analysis"
|
| 8:10 pm - 8:18 pm | Discussion |
| 8:18 pm - 8:34 pm | Yann von Hansen (Technical University of Munich)
"Extracting protein dynamics from single-molecule experiments using dynamic deconvolution"
|
| 8:34 pm - 8:42 pm | Discussion |
| 8:42 pm - 8:58 pm | Andrea Soranno (University of Zurich)
"Quantifying internal friction in unfolded and intrinsically disordered proteins"
|
| 8:58 pm - 9:06 pm | Discussion |
| 9:06 pm - 9:22 pm | Hoi Sung Chung (National Institutes of Health)
"Measurement of average transition-path time for protein folding in single molecule FRET experiments"
|
| 9:22 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Protein aggregation |
| Discussion Leaders: Sheena Radford (University of Leeds) and Steven Plotkin (University of British Columbia)
|
| 9:00 am - 9:16 am | Priyanka Narayan (University of Cambridge)
"A generic mechanism of action of small, ATP-independent chaperones on the aggregation and toxicity of amyloid-beta oligomers"
|
| 9:16 am - 9:24 am | Discussion |
| 9:24 am - 9:40 am | Yu-Shan Lin (Stanford University)
"Investigating how peptide length and a pathogenic mutation modify the structural ensemble of amyloid beta monomer"
|
| 9:40 am - 9:48 am | Discussion |
| 9:48 am - 10:04 am | Adam Trexler (Yale University)
"Probing the effects of the cellular environment on alpha-synuclein structure"
|
| 10:04 am - 10:12 am | Discussion |
| 10:12 am - 10:28 am | Patricia Faisca (University of Lisbon)
"Identification and structural characterization of a common aggregation-prone intermediate in the folding pathways of spc-SH3 amyloidogenic variants"
|
| 10:28 am - 10:36 am | Discussion |
| 10:36 am - 10:52 am | Zhiping Jiang (National Institutes of Health)
"Effects of membrane lipids on the conformation and aggregation of the repeat domain of a functional amyloid, Pmel17"
|
| 10:52 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:42 pm | Theory and simulations of protein folding and function |
| Discussion Leaders:
Edward O'Brien (University of Cambridge) and Zhechun Zhang (University of Maryland)
|
| 1:30 pm - 1:46 pm | David de Sancho (University of Cambridge)
"Matching theory and experiment for primary peptide folding"
|
| 1:46 pm - 1:54 pm | Discussion |
| 1:54 pm - 2:10 pm | Govardhan Reddy (University of Maryland)
"The folding mechanism of green fluorescent protein"
|
| 2:10 pm - 2:18 pm | Discussion |
| 2:18 pm - 2:34 pm | Andrea Kravats (University of Cincinnati)
"Probing the coupling between intra-ring allostery of the ClpY nanomachine and translocation of a substrate protein"
|
| 2:34 pm - 2:42 pm | Discussion |
| 2:42 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
