Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Finding the Bottom of the Funnel: Protein Folding Pathways
3:45 pm - 3:55 pm
"Co-Translational Folding Allows Misfolding-Prone Proteins to Circumvent Deep Kinetic Traps"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
"Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
"Unravelling the Folding and Threading Mechanism of the “Knot-Like” Topology in Leptin"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamics, Stability and Function
7:30 pm - 7:40 pm
"Near Native Misfolding into Semi- or Non-Functional States is Prevalent Across the Proteome"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Structural studies of bio-hacking insect proteins"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"The SARS-CoV-2 Spike Reversibly Samples an Open-Trimer Conformation Exposing Novel Epitopes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Encounters on The Membrane: The Role of Charged Peptides in Bilayer Disruption"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"How Does Sequence Affect the Dynamics of a Cryptic Allosteric Site in Ebolavirus VP35?"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Polyethylene Glycols and Protein Stability"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Developing Tools to Probe DNAJB6 Dynamics in PolyQ Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Intrinsic Disorder, Complicated Landscapes and Methods to Explore Them
9:00 am - 9:10 am
"Tuning the Formation of Protein-Nucleic Acid Condensates"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Determinants of E3 Ligase Adaptor SPOP Binding to Intrinsically Disordered Substrates"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"AlphaFold2 Fails to Predict Protein Fold Switching"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Measuring Equilibrium Unfolding Free Energy Changes of Membrane Proteins by Single-Molecule Force Spectroscopy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Capturing Protein Conformational Dynamics through Information Bottleneck and Molecular Dynamics"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Integrating Fluorinated Amino Acids into the Framework of the AMBER ff15ipq Force Field"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Understanding the impact of indels on protein stability and function using deep mutational scanning"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Finding the Mentorship You Need to Succeed
1:30 pm - 2:20 pm
Panel Discussion
Panel Discussion Finding the Mentorship You Need to Succeed
2:20 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes