Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Takes on Transport Along the Secretory Pathway
7:40 pm - 8:05 pm
"Kinetic Mapping of the Secretory Pathway"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Cytoskeletal Fences and Transmembrane Pickets: Diffusional Barriers at the Plasma Membrane"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Genetic Architecture of Insulin Secretion"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Cellular Calcium Stress Induces Golgi Fragmentation Through PKCa Activation"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endocytic Pathway Trafficking and Connections to the Secretory Pathway
9:00 am - 9:25 am
"Sorting of Endolysosomal Proteins at the Golgi Complex"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Multiple Roles of CORVET and HOPS Tethering Proteins in Membrane Trafficking"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"GPP130 and CASC4 Are Novel Substrates of PC7 and Furin: Investigating Their Roles in Cancer Progression"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Dense-Core Granule Biogenesis in Drosophila Secondary Cells Requires Cross-Talk Between the Secretory and Endosomal Pathways and a Rab6 to Rab11 Transition"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Golgi Response to Cellular Stress"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Live Imaging of Proprotein Convertase Activities at Subcellular Resolution"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Updates on Processing (and Beyond) in the Secretory and Endocytic Pathways
7:30 pm - 7:55 pm
"PCSK1 and proSAAS in Human Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Lessons on the Role of POMC Derived Peptides in Obesity from Man's Best Friend"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"The Non-Enzymatic Functions of the Proprotein Convertases: PCSK9 and PCSK7 and Their Relationship to Dyslipidemia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"D-Amino Acid Containing Neuropeptides"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Treatment Mechanisms Targeting Diabetes, Obesity, Metabolic Syndrome et al .
9:00 am - 9:25 am
"Amplifying Insulin Secretion in β-Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Beta Cell Loss of Prohormone Convertase 1/3 or Carboxypeptidase E Does Not Impair Glycemic Control"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Domains Responsible for trans -Golgi Network Targeting of the Peripheral Membrane Protein HID-1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
"Novel Unimolecular Multiagonists for the Treatment of Obesity and Diabetes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Targeting Pancreatic Cancer by Conformational Selective Anti-MMP7 Inhibitory Antibody"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Dissecting DDX3X Nuclear Export to Unlock Novel Anti-Viral Therapeutic Approaches"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Significance of Intra-Membrane Proteolysis and Proteolytic Events at the Cell Surface
7:30 pm - 7:55 pm
"A Single-Molecule View of Rhomboid Protease Function Inside the Cell Membrane"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"iRhoms: Key Regulators of ADAM17-Dependent TNF and EGFR Signaling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Intramembrane Protease SPPL2c Is Critical for Male Germ Cell Development by Processing Selected Tail-Anchored Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Substrates and Functions of ADAM10 in the Mammalian Nervous System"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Secreted Metalloproteases ADAMTS9 and ADAMTS20 Have a Dual Role in Ciliogenesis and Extracellular Matrix Proteolysis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Processing in Development, Reproduction and Ageing
9:00 am - 9:25 am
"Control of Proteolysis in Drosophila Terminal Patterning"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Regulation of BMP Homo- and Heterodimer Activity by Prodomains and Interactions with the ECM"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Can the Sex Life of Drosophila Tell Us Anything About the Processing of Invadolysin?"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mitonuclear Communication in Response to Nutrient Stress"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"An Independent Role of the Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Role of Furin in Obesity and Type 2 Diabetes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Secretory Proteases and Inhibitors in Health and Disease
7:30 pm - 7:55 pm
"The Protease ADAM17 Drives Inflammation and Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"KLK Peptidases as Secreted Mediators of Invasive Processes in Prostate and Ovarian Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"An Inside-out Role for Cathepsin B in Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The KDEL Receptors Regulate Secretion of Endoplasmic Reticulum Resident Proteins Under Endoplasmic Reticulum Stress"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Neuropeptide Processing Proteases in Health and Disease: A Role for Endothelin Converting Enzyme in Modulating Pain"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Challenges in Protein Processing and Secretion
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"The Marriage of Experiment and Theory in Investigating the Molecular Mechanisms of Action of Proteases and Their Inhibitors"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
"GPR3 and Novel GPCR Signaling in Alzheimer's Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Cell-Associated, Heparin-Like Molecules Modulate the Ability of LDL to Regulate PCSK9 Uptake"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"Chromogranin A, the Major Lumenal Protein in Chromaffin Granules, Controls Fusion Pore Expansion and Its Expression in Granules Is Regulated"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Sorting of a Multi-Subunit Ubiquitin Ligase Complex in the Endolysosome System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Modular Lipid Binding by Yeast Vps13p Can Promote Apposition of Bilayers with Distinct Lipid Compositions"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion: Therapeutic Options and Outcome Studies: From Cell Biology and Genetics to Future Perspectives
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms and Approaches in Protein Processing and Sorting in Signaling
7:30 pm - 7:55 pm
"Development of a nM Molecular Corrector Specifically Rescuing MALT1 Activity in NFkB Signalling in Immunodeficency"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Regulation of Prolonged GPCR Signaling that Creates Sequential Neuronal Activation Within Circadian Pacemaker Circuit"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Sphingolipid Metabolism Impinges on Calcium-Dependent Sorting of Secretory Cargo in the trans -Golgi Network"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Analysis of Protein Sorting at the trans -Golgi Network Through STORM Super-Resolution Imaging"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Multifaceted Regulation of Exocytosis by Synaptotagmin-7"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure