Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Endoplasmic Reticulum Protein Import and Folding
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"Endoplasmic Reticulum Architecture and Metabolic Regulation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Quality Control of Membrane Proteins at the Endoplasmic Reticulum"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"How Membrane Proteins Shape Rough ER Sheets"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling, ER-To-Golgi, and Intra-Golgi Transport
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Cryo-Electron Tomography of COPII Coats"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"A Tale of Tails: Membrane Insertion of Terminal Transmembrane Domains"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Dynamic O-GlcNAcylation on the Disordered Domain of Sec24D Regulates COPII Function and is Required for Collagen Transport"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Substrate-Directed Cntrol of N-glycosylation in the Endoplasmic Reticulum Calibrates Signal Reception at the Cell-Surface"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
"Mechanosensing and Mechanotransduction at the Endoplasmic Reticulum"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"TUG Protein Acts Through a Disordered Region to Organize the Early Secretory Pathway"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"The Transcriptional Program of Golgi Biogenesis"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Rethinking the Secretory Pathway"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"A TANGO at the Golgi for Trafficking and Gene Expression"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
"Controlling Protein Function by Induced Proximity"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"COPII with ALG2 and ESCRTs Control Lysosome-Dependent Microautophagy of ER Exit Sites"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Mechanical Compression Accelerates ER Luminal Diffusivity"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Photoswitching FRET Defines the Interaction Boundaries Between the Rab1 GTPase and Secretory Cargo During ER to Golgi Transport."
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Capturing Proteostasis and Trafficking at Work Through the Lens of Spatial Covariance Machine Learning"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Cellular Membrane Traffic of Neuron by Cryo-ET"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
TGN Processing, Sorting, and Export
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
"Spatiotemporal Dynamics of Secretory Protein Export"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"The Orphan Receptor GPRC5A Activates a TGN-Based Signalling Pathway to Regulate Basolateral Traffic and Secretion in Epithelial Cells"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Post-Golgi Trafficking of Frizzled-6 by VTI1B and SCAMP2 to Establish Planar Cell Polarity"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"An Unbiased Proteomic and CRISPR Screen Reveals Novel Machinery in the Constitutive Secretory Pathway"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Location Matters: Deciphering PKD Signaling on Endomembranes"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:20 am
"Lipid Trafficking in the Secretory Pathway"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"PCSK7: A Novel Regulator of Apolipoprotein B and a Potential Target Against Non-Alcoholic Fatty Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"VPS13B is Localized at the Cis-trans Golgi Complex Interface and is a Functional Partner of FAM177A1"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"VARP Binds SNX27 to Promote Endosomal Supercomplex Assembly"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Novel Functions of Sec17 (SNAP) and Sec18 (NSF) Prior to Membrane Fusion"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exocytosis and Mechanisms of Unconventional Protein Secretion
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Molecular Mechanism and Machinery Driving Unconventional Secretion of Fibroblast Growth Factor 2"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Packaged Release and Localized Secretion of Signaling Molecules by Migrasomes"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"TMED-Mediated Translocation in Unconventional Protein Secretion"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Architecture of Synaptic Vesicles and Synapses Revealed by Cryo-Electron Tomography"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Turbocharging Synaptic Transmission"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"Autophagy Receptors Function at Distinct Endoplasmic Reticulum Domains"
9:20 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Selective Autophagies: Chaperones Making the Degradation Call"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Quantitative Mapping of Autophagic Cargo During Nutrient Stress Reveals Membrane Receptors For Golgiphagy"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Metabolic Adaptations to Autophagy Inhibition in Cancer"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Maintenance of Lysosome Integrity by ATG9A"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Novel Roles for Autophagy Proteins in Lysosome Homeostasis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Autophagy and Related Vesicular Trafficking Processes in Cancer"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Revealing the Origin of Nonselective Autophagosomes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Roles of Biomolecular Condensation in Trafficking and Autophagy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"An Anisotropic TFG Condensate Spatially Compartmentalizes the Early Secretory Pathway"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Coupling of Protein Condensation as a Determinant of Functional Membrane Organization"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"The Role of Dynamic Ca2+ Signals in Specifying Autophagosome Initiation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Disordered Protein Networks as Dynamic Catalysts of Endocytosis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Lipid Trafficking at Membrane Contact Sites by Ist2/Osh6 System"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Processing, Trafficking, and Secretion in Neurological Diseases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"The Structure and Dynamics of the Endoplasmic Reticulum: Insights from the Hereditary Spastic Paraplegias"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Hypomorphic Variants of SEL1L-HRD1 ER-Associated Degradation are Associated With Neurodevelopmental Disorders and Premature Death"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"SCAMPS Involved in the Unconventional Secretion of Alpha-Synuclein"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Pathologic α-Synuclein Cell-to-Cell Spread by Lipid Translocases in Parkinson’s Disease"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"Rab GTPase Phosphorylation in Parkinson's Disease"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Molecular Motors in Vesicular Trafficking"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Small Molecule Modulator of the Autophagy Lysosomal Pathways That Increases Net Retrograde Lysosomal Transport Resolves Alzheimer's Disease - Linked Pathologies"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Systematic Analysis of Cellular Proteomes and Lipidomes in Lysosomal Storage Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Molecule Tracking of ER-to-Lipid Droplet Protein Movement Reveals a Bidirectional Pathway Through Seipin Complex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Processing, Trafficking, and Secretion in Diabetes and Other Metabolic Disorders
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
"Quantitative Mapping and Visualizing of Insulin Hormone Maturation"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Role of Sec61alpha2 Translocon in Insulin Biosynthesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Elucidating Cellular Lipid Storage via Spatial Proteomics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Inceptor is A Novel Regulator of Insulin Signaling and Content in Beta Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The ESCRT-I Component Tsg101 Regulates Hepatocellular Inflammation in End-Stage Liver Diseases"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Identification of Genes that Control Insulin Secretion"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure