SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | PROTEIN IMPORT INTO MITOCHONDRIA |
7:35 pm - 7:40 pm | Discussion Leader: Klaus Pfanner (University of Freiburg) |
7:40 pm - 8:00 pm | Carla Koehler (UCLA) "A novel pathway for RNA translocation into mitochondria" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Trevor Lithgow (Monash University) "Evolution of protein transport pathways" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Agnieszka Chacinska (IIMCB) "Biogenesis of mitochondrial proteins: the MIA pathway" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Marten van der Laan (University of Freiburg) "Modular sorting of a mitochondrial Inner membrane protein" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | TRANSLOCATION THROUGH SEC YEG/SEC61 COMPLEX |
9:00 am - 9:05 am | Discussion Leader: Linda Randall (University of Missouri) |
9:05 am - 9:25 am | Arnold Driessen (University of Groningen) "Dynamics and mechanisms of the bacterial preprotein translocase" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Shu-ou Shan (Cal Tech) "Sequential fidelity checkpoints govern substrate selection during co-translational protein targeting" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Andreas Kuhn (University of Hohenheim) "Bacterial membrane insertion. From in vivo to single molecules" |
10:20 am - 10:25 am | Discussion |
10:25 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Roland Beckmann (University of Munich) "Visualization of a ribosome-Sec complex in its membrane environment" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Tom Rapoport (Harvard Medical School) "Mechanisms of SecA-mediated protein translocation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Giorgos Gouridis (IMBB Forth) "Signal peptides are allosteric activators of the protein translocase" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | BIOGENESIS OF THE PEROXISOME |
7:30 pm - 7:35 pm | Discussion Leader: Suresh Subramani (UCLA) |
7:35 pm - 7:55 pm | Ralf Erdmann (University of Bochum) "Dissection of the Peroxisomal Protein Import Machinery" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Bonnie Bartel (Rice University) "Peroxisome biogenesis in Arabidopsis" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Yukio Fujiki (Kyushu University) "Peroxisomal import of matrix and membrane proteins" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Richard Rachubinski (University of Alberta) "A role for the Sec61 translocon in peroxisome membrane protein biogenesis" |
9:15 pm - 9:25 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ER AND PERIPLASM ASSOCIATED DEGRADATION PATHWAYS |
9:00 am - 9:05 am | Discussion Leader: Art Johnson (Texas A&M University) |
9:05 am - 9:25 am | Michael Erhmann (University Duisburg-Essen) "Function and regulation of the periplasmic protease/chaperone machine DegP" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Randy Hampton (UCSD) "Analysis of late stage ERAD by genetic and biochemical approaches" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:40 am | Coffee Break |
10:40 am - 10:55 am | Michaela Fuerst (University of Freiburg) "The role of PpiD in Sec-mediated protein translocation" |
10:55 am - 11:00 am | Discussion |
11:55 am - 11:15 am | Raffaele Ieva (NIH) "Interaction of the BAM complex with the passenger and β domains of an autotransporter" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Jan Riemer (Technical University of Kaiserslautern) "The reconstitution of oxidative folding in the IMS of mitochondria" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Nicoleta Bondar (UC-Irvine) "Pathways for opening the SecYEG protein translocon: role of hydrogen bonding and signal peptide interactions" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Hand-Georg Koch (University of Freiburg) "Analyzing the dynamic interactions of the bacterial SRP receptor in vivo" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | STRUCTURAL BIOLOGY OF PROTEIN TRANSPORT |
7:30 pm - 7:35 pm | Discussion Leader: Harris Bernstein (NIH) |
7:35 pm - 7:55 pm | Babis Kalodimos (Rutgers University) "Structural and dynamic basis for the assembly of the Sec translocase" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Natalie Strynadka (University of British Columbia) "Structure-based analysis of the Type III secretion apparatus of
pathogenic bacteria" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Robert Keenan (University of Chicago) "Molecular basis of tail-anchored membrane protein targeting to the ER" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Irmi Sinning (Heidelberg University) "cpSRP43 provides an adaptor for multiple interactions in post-translational targeting" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NONCONVENTIONAL PROTEIN TRANSPORT PATHWAYS |
9:00 am - 9:05 am | Discussion Leader: Ross Dalbey (Ohio State University) |
9:05 am - 9:25 am | Ana Maria Cuervo (Albert Einstein College of Medicine) "Crossing the lysosomal membrane through chaperone-mediated autophagy" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Boris Striepen (University of Georgia) "The plastid of apicomplexan parasites" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:40 am | Coffee Break |
10:40 am - 10:55 am | Susan Buchanan (NIH) "Import of bacteriocins across the bacterial outer membrane: engineering a phage lysin to kill Yersina pestis" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Jeff Cox (UCSF) "Regulation of ESX-1 Secretion in Mycobacterium tuberculosis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Sigfried Musser (TAMU) "Single molecule measurements of transport complex assembly and disassembly during nucleocytoplasmic transport" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Aurélie Barnéoud-Arnoulet (CNRS Marseille) "A proteolytic cleavage regulates the translocation of a bacterial toxin" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Birgitta Norling (Nanyang Technological University) "A model for membrane organization and protein sorting in the cyanobacterium Synechocystis sp. PCC 6803" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | INTEGRATION OF MEMBRANE PROTEINS |
7:30 pm - 7:35 pm | Discussion Leader: Nica Borgese (University of Milan) |
7:35 pm - 7:55 pm | Manu Hegde (NIH) "Tail-anchored membrane protein insertion into the ER" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | David Andrews (McMaster University) "An image based screen for genes involved in the assembly of ER membranes" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Doron Rapaport (University of Tuebingen) "Multiple pathways in the biogenesis of mitochondrial outer membrane proteins" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Bill Clemons (Caltech) "A novel structure of a complex in the Get pathway" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | DIVERSITY OF PROKARYOTIC PROTEIN EXPORT PATHWAYS |
9:00 am - 9:05 am | Discussion Leader: Guy Cornelis (Biozentrum, University of Basel) |
9:05 am - 9:25 am | Vassilis Koronakis (University of Cambridge) "Structure and function of a bacterial multidrug efflux pump" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Francoise Jacob-Dubuisson (Institut Pasteur) "Secretion by the TPS pathway: anatomy and function of the FhaC transporter" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:40 am | Coffee Break |
10:40 am - 10:55 am | Andreas Diepold (University of Basel) "Assembly of the Yersinia type III secretion system" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Susan Lea (Oxford) "Structural thoughts on type three secretion" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Konstantin Korotkov (University of Washington) "Structure of the outer membrane secretin of the type 2 secretion system using crystallization chaperones and cryo-electron microscopy" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Tomoya Tsukazaki (University of Tokyo) "Structural analysis of bacterial Sec translocon machinery" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Elisabet Mandon (University of Massachusetts Medical School) "Translocon gating depends upon coordinated movement of lateral gate transmembrane spans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PROTEIN IMPORT INTO CHLOROPLASTS |
7:30 pm - 7:35 pm | Discussion Leader: Steve Theg (UC, Davis) |
7:35 pm - 7:55 pm | Danny Schnell (University of Massachusetts) "The diversity and function of chloroplast protein translocons" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Enrico Schleiff (University of Frankfurt) "Discussion of structural, energetic and mechanistic aspects of protein
translocation across chloroplast envelopes" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Paul Jarvis (University of Leicester) "Genetic analysis of chloroplast protein import in Arabidopsis" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Jose Celedon (University of Florida) "Biochemical evidence that the twin arginine receptor complex is multivalent for binding and transport" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |