Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | General Principles of Protein Targeting to Different Cellular Locations |
| Discussion Leader: Tassos Economou (Rega Institute for Medical Research, KU Leuven, Belgium) |
7:40 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:10 pm | Manu Hegde (MRC Laboratory of Molecular Biology, United Kingdom) "Transmembrane Domain Recognition During Protein Targeting, Translocation, and Degradation" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Paul Jarvis (University of Oxford, United Kingdom) "Protein Transport in Plastids" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Nikolaus Pfanner (Universitaet Freiburg, Germany) "Transport and Assembly
of Mitochondrial Proteins" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Targeting to Membranes |
| Discussion Leader: Matthias Muller (Universitaet Freiburg, Germany) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Irmgard Sinning (University of Heidelberg, Germany) "Mechanism of Protein Targeting to the Endoplasmic Reticulum" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Robert Keenan (University of Chicago, USA) "Targeting of Tail-Anchored Membrane Proteins
to the Endoplasmic Reticulum" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:50 am | Stephen White (University of California, Irvine, USA) "The Fate of Signal Sequences and Transmembrane Segments Inserted by SecA" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Hans-Georg Koch (University of Freiburg, Germany) "O-Translational Protein Targeting: SRP Interaction with the Ribosomal Tunnel Interior Facilitates Early Substrate Recognition" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Gunnar Von Heijne (Stockholm University, Sweden) "Cotranslational Protein Folding" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Fu-Cheng Liang (California Institute of Technology, USA) "Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-Regulated Substrate Capture and Release" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Richard Zimmermann (Saarland University, Germany) "Protein Transport into the Human ER" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein Translocation Across Membranes |
| Discussion Leader: Richard Zimmermann (Saarland University, Germany) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Long Li (Harvard Medical School, USA) "Crystal Structure of a Substrate-Engaged SecY Protein-Translocation Channel" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Ekaterina Eimer (Institute for Biochemistry and Molecular Biology, University of Freiburg, Germany) "Intramembrane, Charged Residues Important for the Functional Assembly of the Tat Translocase" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Toshiya Endo (Kyoto Sangyo University, Japan) "Protein Import into Mitochondria" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Ben Berks (University of Oxford, United Kingdom) "Assembling the Tat Translocase" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Insertion into Membranes |
| Discussion Leader: Ross Dalbey (Ohio State University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Andreas Kuhn (University of Hohenheim, Germany) "Bacterial Membrane Protein Insertion" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Thomas Miller (California Institute of Technology, USA) "Long Timescale Molecular Dynamics Simulation
of Protein Translocation at the Sec61p Complex" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Marcelo Sousa (University of Colorado Boulder, USA) "Structure and Mechanism of the Beta-Barrel Assembly Machine" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Roland Beckmann (Gene Center, University Munich, Germany) "Structure and Dynamics of the YidC:Ribosome Complex upon Membrane Protein Biogenesis" |
11:30 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Arnold Driessen (University of Groningen, The Netherlands) "Cellular Localization and Lipid Activation of
the SecA Motor Protein" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Shinobu Chiba (Kyoto Sangyo University, Japan) "Use of Bacillus subtilis MifM to Dissect the YidC Functions to Facilitate Membrane Protein Insertion" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Dislocation and Quality Control |
| Discussion Leader: Randolph Hampton (University of California, San Diego, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Yihong Ye (National Institutes of Health, USA) "Unconventional Protein Secretion in Protein Quality Control" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Brendan Battersby (University of Helsinki, Finland) "Quality Control of Mitochondrial Protein Synthesis Is Required for Membrane Integrity" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Malaiyalam Mariappan (Yale University, USA) "A New Role for the
Sec61 Translocon in the UPR" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Terrence Oas (Duke University, USA) "The Effect of Thermodynamic Stability on the Secretion of a Rapidly Unfolding/Folding Protein" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Protein Import into Organelles |
| Discussion Leader: Carla Koehler (University of California, Los Angeles, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Ralf Erdmann (Ruhr-University Bochum, Germany) "Protein Import into Peroxisomes" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Peter Rehling (University of Gottingen, Germany) "Protein Transport of Presequence-Containing Precursors into Mitochondria" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:50 am | Christopher Carrie (Ludwig-Maximilians-Universität München, Germany) "A Plant Mitochondrial Tat Pathway" |
10:50 am - 10:55 am | Discussion |
10:55 am - 11:10 am | Michael Conti (University of California, Los Angeles, USA) "Small Molecule Inhibitors Display Distinct Phenotypes in a Parkinson’s Disease Mechanism" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Danny Schnell (Michigan State University, USA) "Multi-Functional Roles for the POlypeptide TRansport Associated (POTRA) Domains of Toc75 in Chloroplast Protein Import" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Carole Dabney-Smith (Miami University (Ohio), USA) "Characterization of a Chloroplast Twin Arginine Mutant in Arabidopsis thaliana Deficient in the Membrane Protein Hcf106" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Chris Williams (University of Groningen, The Netherlands) "Mapping the PMP Export Pathway of Peroxisomes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Regulation of Translocation |
| Discussion Leader: Bil Clemons (California Institute of Technology, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Ming Liu (University of Michigan, USA) "Targeting Proinsulin Dimerization Interface to
Prevent Beta Cell Failure and Diabetes Caused by Misfolded Proinsulin" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Katharina Wiesemann (Goethe University Frankfurt, Germany) "The TOC GTPases Are Regulated by a Multistep Dimerization Cycle" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Hsou-Min Li (Academia Sinica, Taiwan) "CRK Support for a Sweet Hypothesis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Randolph Hampton (University of California, San Diego, USA) "Giving the Cold Shoulder to Retrotranslocation: Genetic Strategies to Discover ERAD Dis-Location Factors" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pathogenic Secretion |
| Discussion Leader: Harris Bernstein (National Institutes of Health, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Gabriel Waksman (Birkbeck, University of London, United Kingdom) "Structural and Molecular Biology of Bacterial Type IV Secretion Systems" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Patricia Clark (University of Notre Dame, USA) "Connections Between Autotransporter Protein Folding Properties and Secretion Efficiency" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Konstantin Korotkov (University of Kentucky, USA) "Structural Basis of PE-PPE Protein Translocation by Mycobacterial ESX Secretion Systems" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:25 am | Shruthi Hamsanathan (Texas A&M University, USA) "The Hairpin-Hinge Model of Tat Protein Transport" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Vivianne Goosens (Imperial College London, United Kingdom) "Unravelling Type 4 Pili Assembly" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Daniel Wall (University of Wyoming, USA) "Bacterial Kin Recognition and Protein Transport Between Outer Membranes" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Paradigms in Translocation |
| Discussion Leader: Hsou-Min Li (Academia Sinica, Taiwan) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Feng Shao (National Institute of Biological Sciences, China) "An Iron-Containing Dodecameric Heptosyltransferase Family Modifies Bacterial Autotransporters in Pathogenesis" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:20 pm | Ying Zhang (University of Freiburg, Germany) "Cotranslational Intersection Between the SRP- and GET-Targeting Pathways to the ER of Saccharomyces cerevisiae" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Tracy Palmer (University of Dundee, United Kingdom) "The Type VII Secretion System of Staphylococcus
aureus" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Siegfried Musser (Texas A&M Health Science Center, USA) "Macromolecular
Crowding in Nuclear Pores" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |