| Sunday Evening Session | Keynote Lecture |
Discussion Leader: Lynne Regan
- Brian Matthews, Howard Hughes Medical Institute
“Structure isn't everything but it sure helps!”
| Monday Morning Session | The Basis of Protein Stability |
Discussion Leader: Thomas Baldwin
- Gary J. Pielak, University of North Carolina
“Molecular Crowding & Protein Biophysics”
- Marty Scholtz, Texas A&M U.
"Contributions of Long-Range Electrostatic Interactions to Protein Stability"
- Wayne Bolan, Univ. of Texas Medical Branch
“Experimental Metrics for Determining the Origins of Naturally Occurring Organic Osmolytes Effects on Proteins”
- Franz Schmid, U. Bayreuth
"The thermostability of proteins. Molecular origins and increase by directed evolution."
- Martin Stone
"Interplay of protein dynamics with structural stability and ligand binding"
| Monday Evening Session | Evolution and Design of Protein Folds and Protein Functions |
Discussion Leader: Lila Gierasch
- Matt Cordes, Biological Sciences West
"The Evolution of Protein Folds"
- David Baker, University of Washington
"Prediction and design of protein structures and folding mechanisms"
- Bill DeGrado, University of Pennsylvania
"Design of Tubular Proteins"
| Tuesday Morning Session | Experimental Folding I |
Discussion Leader: David Goldenberg
- Walter Englander, University of Pennsylvania School of Medicine
“How we think proteins fold: Intermediates, barriers, pathways”
- C. Robert Matthews, University of Massachusetts, Worcester
"Rough energy landscapes that lead to parallel channels in folding: monomeric dihydrofolate reductase and dimeric Trp repressor"
- Barry T. Nall, University of Texas
“Kinetic Traps in Cytochrome c Folding”
- Dan Raleigh, SUNY at Stony Brook
"Folding of the Ribosomal Protein L9"
- Lila M. Gierasch, University of Massachusetts
“Insights into early events in the folding of CRABP”
| Tuesday Evening Session | Experimental Folding II |
Discussion Leader: Marty Scholtz
- Heinrich Roder, Fox Chase Cancer Center
“Structural properties and mechanistic role of early intermediates in protein folding”
- Carla Mattos
"Water on Protein surfaces: structure, function and design"
- Sheena Radford, University of Leeds
“Helical protein folding: lessons learned from the bacterial immunity proteins”
| Wednesday Morning Session | Proteins and Medicine |
Discussion Leader: Sheena Radford
- Rachel Klevit, University of Washington
“Structure of a BRCA1/BARD1 Complex: a Heterodimeric RING-RING Interaction”
- Virgina L. Rath, Pfizer
"Discovery and design of an allosteric inhibitor."
- Andrew Miranker, Yale University
"Novel pathways of amyloid formation by beta-2 microglobulin"
- Ge Zhang, Genaissance Pharmaceuticals, Inc.
"cSNPs in Pharmaceutically Relevant Genes and Possible Effects on Proteins"
- Alexei Buevich
"NMR characterization of peptide models in collagen folding diseases"
| Wednesday Evening Session | Genomics and Bioinformatics |
Discussion Leader: Shelly Rackovsky
- Andrzej Joachimiak, Structural Biology Center
"From Genome to Proteome"
- Steven E. Brenner, University of California at Berkeley
“Genome Annotation & Protein Structure”
- Mark Gerstein, Yale University
“Integrative Proteomics”
| Thursday Morning | Late-Breaking Session |
Discussion Leader: Franz Schmid
- Tim Clackson, ARIAD Pharmaceuticals, Inc.
"Engineered proteins as building blocks for inducible gene therapies: design and luck"
- Valerie Daggett, University of Washington
"Mapping the early steps in the conversion of the prion protein"
- Bill Montfort, University of Arizona
"Linking structure to dynamics: nitric oxide transport by blood-sucking insects"
- Deborah Wuttke
"Structural and Biochemical Studies of the Recognition of Single-stranded DNA at Telomeres by the Essential Protein Cdc13"
- Eugene Shakhnovich, Harvard University
''Focused combinatorial chemistry in silico: Theory and design of novel picomolar inhibitor for a known enzyme''
| Thursday Evening | New and Emerging Technologies |
Discussion Leader: George Makhatadze
- Lois Pollack, Cornell University
"Microfabricated Mixers for Rapid Kinetic Experiments on Macromolecules"
- Don Low
"Metalloprotein Engineering by Chemical Synthesis"
- Gordon Tollin, University of Arizona
“Plasmon-waveguide resonance spectroscopy, a new tool for studying membrane proteins; Application to the human delta-opioid receptor”
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