SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome: Christopher Hill (University of Utah) / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | OPENING KEYNOTE SESSION |
7:40 pm - 7:45 pm | Discussion Leader: Terrence Oas (Duke University) |
7:45 pm - 8:35 pm | Jeffery W. Kelly (The Scripps Research Institute)
"Understanding and Ameliorating Diseases of Protein Homeostasis" |
8:35 pm - 8:55 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | PROTEIN CHEMISTRY & BIOPHYSICS IN CELLS |
9:00 am - 9:05 am | Discussion Leader: Lila Gierasch (University of Massachusetts) |
9:05 am - 9:30 am | Patricia Clarke (University of Notre Dame)
"Folding and secretion of bacterial extracellular virulence factors" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jonathan Weissman (University of California, San Francisco)
"A molecular caliper mechanism for determining very long chain fatty acid length" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Ryan Mehl (Franklin & Marshall College)
"Site-specific photocrosslinking and fluorinated amino acids in vivo and in vitro" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | James Bardwell (University of Michigan)
"Laboratory evolution of protein folding catalysts" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Ursula Jakob (University of Michigan)
"Activation of a chaperone by stress-induced protein folding" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Amy Keating (Massachusetts Institute Of Technology)
"Combining computation and experiment to elucidate protein interaction specificity" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MOTION & FUNCTION |
7:30 pm - 7:35 pm | Discussion Leader: Carol Post (Purdue University) |
7:35 pm - 8:00 pm | Ivet Bahar (University of Pittsburgh)
"Network models for protein dynamics and allostery" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Dorothee Kern (Brandeis University)
"Dynamic personalities of proteins empower function" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Andrew Lee (University of North Carolina)
"Using Intramolecular Dynamics by NMR to Probe Long-Range Effects in Native Proteins" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Poster Talk: Stefan Lutz (Emory University)
"Exploiting temperature-dependent substrate promiscuity for the efficient nucleoside analog activation by thymidine kinase from Thermotoga maritime" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | DISORDER, AGGREGATION, KINETIC STABILITY, & DISEASE |
9:00 am - 9:05 am | Discussion Leader: Andrew Miranker (Yale University) |
9:05 am - 9:30 am | Wilfredo Colón (Rensselaer University)
"Identifying sub-proteomes of kinetically stable proteins" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Ron Kopito (Stanford University)
"Polyglutamine diseases, prions and membrane barriers" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Rohit Pappu (Washington University)
"Conformational equilibria of intrinsically disordered proteins" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Roland Riek (The Salk Institute)
"Structural studies of aggregates" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Jose Sanchez-Ruiz (University of Granada)
"Kinetic stability of proteins in vitro and in vivo" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Francis Tsai (Baylor College Of Medicine)
"Seeing is Believing: Visualizing the Structure of a Protein Disaggregating Machine" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MEMBRANE PROTEINS |
7:30 pm - 7:35 pm | Discussion Leader: Stephen Betz (Neurocrine Biosciences) |
7:35 pm - 8:00 pm | William Clemons (California Institute of Technology)
"Structural studies of protein translocation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Volker Dötsch (Goethe University)
"Structure determination of the bacterial protein TehA by NMR spectroscopy" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Eduardo Perozo (University of Chicago)
"Molecular basis of gating at the K+ channel selectivity filter" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Poster Talk: Emily McCusker (University Of Delaware)
"Refolding Aggregatation-prone GPCRs and G-protein a subunits from inclusion bodies expressed in Escherichia coli" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PROTEIN NETWORKS AND COMPLEXES |
9:00 am - 9:05 am | Discussion Leader: Susan Baxter (San Diego State University) |
9:05 am - 9:30 am | Tom Alber (University of California at Berkeley)
"Protein phosphosignaling in TB" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Leslie Poole (Wake Forest University)
"From peroxiredoxins to cell signaling: Cystein sulfenic acids in catalysis and regulation" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | David LeMaster (Wadsworth Center)
"Intramolecular network analysis of structural, dynamic and thermodynamic additivity in rubredoxin" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | James Bowie (University of California at Los Angeles)
"The role of SAM domains in the construction of large regulatory complexes" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Timothy Ravasi (University of California at San Diego)
"Inferring mammalian Transcriptional Regulatory Networks using protein-protein interactions" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Catherine Eakin (University Of Washington)
"Networks of Protein-Protein Interactions Necessary for Ubiquitination of Estrogen Receptor alpha by BRCA1/BARD1" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MODIFICATION, STRESS & TARGETING |
7:30 pm - 7:35 pm | Discussion Leader: Mary Munson (University of Massachusetts) |
7:35 pm - 8:00 pm | Brenda Schulman (St. Jude Children's Research Hospital)
"Structural insights into ubiquitin-like protein conjugation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Philipp Selenko (Harvard University)
"The structural biology of intrinsically disordered proteins in living cells" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | James Hurley (National Institutes of Health)
"Integration of ubiquitin and phosphoinositide signaling by the ESCRT complexes" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Poster Talk: Lawrence McIntosh (University Of British Columbia)
"Variable Allosteric Regulation Of Ets-1 DNA Binding By Multiple Phosphorylation Of A Flexible, Unstructured Region" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PROTEIN DESIGN, MODELING & PREDICTION |
9:00 am - 9:05 am | Discussion Leader: Stephen Mayo (California Institute of Technology) |
9:05 am - 9:30 am | Homme Hellinga (University of Washington)
"Computational design of biologically active proteins" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Tanja Kortemme (UCSF)
"Design of selective and multi-specific protein interfaces" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Michael Kay (University of Utah)
"Design and Discovery of D-peptide Inhibitors of HIV Entry" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Joel Schneider (University of Delaware)
"The Design of Responsive Peptide Materials" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Hak-Sung Kim (Korea Advanced Institute of Science and Technology)
"Designing a new catalytic function with an existing protein scaffold" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Poster Talk: Brian Kuhlman (University Of North Carolina)
"Redesigning the Ubiquitin Pathway to Identify the Substrates of E3 Ubiquitin Ligases" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | CLOSING KEYNOTE SESSION |
7:30 pm - 7:35 pm | Discussion Leader: Jacquelyn Fetrow (Wake Forest University) |
7:35 pm - 8:25 pm | X. Sunney Xie (Harvard University)
"Single-Molecule Protein Dynamics: From In Vitro to In Vivo" |
8:25 pm - 8:45 pm | Discussion |
8:45 pm - 8:50 pm | Closing Remarks. Gary Pielak (University of North Carolina) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |