| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Lecture |
| Discussion Leader: James Bowie (UCLA) |
| 7:40 pm - 7:45 pm | James Bowie (UCLA)
"Introduction" |
| 7:45 pm - 8:35 pm | Susan Linquist (MIT)
"Protein Folding Empowering Evolutionary Change" |
| 8:35 pm - 8:45 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Protein Folding |
| Discussion Leader: Dan Raleigh (SUNY Stonybrook) |
| 9:05 am - 9:35 am | Sheena Radford (University of Leeds)
"New insights into the molecular mechanism of beta barrel outer membrane protein folding" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Jane Clarke (University of Cambridge)
"Exploring the folding and misfolding of multidomain proteins" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 10:45 am - 11:15 am | Martin Gruebele (University of Illinois)
"Protein folding: comparing in vitro and in vivo" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Brian Volkman (Medical College of Wisconsin)
"Access to the unfolded state as a functional necessity in intrinsically folded proteins" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Poster Talk: Dan Bolon (UMass Medical School)
"Systematic fitness analysis of point mutants" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Design and Engineering |
| Discussion Leader: Stewart Fisher (AstraZeneca) |
| 7:35 pm - 8:05pm | Stewart Loh (SUNY Upstate Medical University)
"Designing protein switches by coupling folding to unfolding" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Lauren Webb (University of Texas, Austin)
"Exploring electrostatic fields at the protein-protein interface" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:25 pm | Sachdev Sidhu (University of Toronto)
"Manipulating Cell Signaling with Synthetic Proteins" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Protein Aggregation/Amyloidogenesis |
| Discussion Leader: Sheena Radford (University of Leeds) |
| 9:05 am - 9:35 am | Joan Shea (University of California, Santa Barbara)
"Simulations of protein aggregation in the cellular milieu" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Matt Chapman (University of Michigan)
"Amyloids in bacterial biofilm formation" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 10:45 am - 11:15 am | Dan Raleigh (SUNY Stonybrook)
"Mechanism and inhibition of islet amyloid formation" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Poster Talk: Jennifer Maynard (U. Texas at Austin)
"Stabilization of protein at high concentrations crowding into nanoclusters" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 12:00 pm | Poster Talk: Raquel Lieberman (Georgia Institute of Technology)
"Biophysical analysis of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder" |
| 12:00 pm - 12:05 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Protein Biogenesis |
| Discussion Leader: Susan Buchanon (National Institutes of Health) |
| 7:35 pm - 8:05pm | Bill Skach (Oregon Health Science Center)
"Nascent protein folding on the ribosome" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Angel Garcia (Rensselaer Polytechnic Institute)
"Simulations of the folding unfolding of proteins under different solvent and pressure conditions" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:25 pm | Bil Clemons (California Institute of Technology)
"Higher-order assemblies during tail-anchor targeting by the GET pathway" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Large Cellular Assemblies |
| Discussion Leader: Bill Skach (Oregon Health Science Center) |
| 9:05 am - 9:35 am | Todd Yeates (University of California, Los Angeles)
"Bacterial microcompartments: metabolic organelles built from protein subunits" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Phoebe Stewart (Vanderbilt University)
"CryoEM structure determination of large assemblies combined with de novo protein prediction methods and molecular dynamics simulations" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 10:45 am - 11:15 am | Xiaowei Zhuang (Harvard University)
"Single-molecule studies of chromatin remodeling" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Susan Buchanan (National Institutes of Health)
"Import of bacteriocins across the bacterial outer membrane: engineering a phage lysin to kill Yersina pestis" |
| 11:55 pm - 12:05 pm | Discussion |
| 12:05 am - 12:20 pm | Poster Talk: Elizabeth Meiring (University of Waterloo)
"Modular evolution and the origins of symmetry: design of a threefold symmetric globular protein" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Dynamics |
| Discussion Leader: Joan Shea (University of California, Santa Barbara) |
| 7:35 pm - 8:05 pm | Taejip Ha (University of Ilinois)
"SiMPull: Single Molecule Pulldown" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Jeff Peng (University of Notre Dame)
"Protein Dynamics and Signal Propagation" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:10 pm | Poster Talk: Blake Hill (Johns Hopkins University)
"C'mon In, The Membrane's Fine: Protein Amphitropism in Mitochondrial Fission and Apoptosis" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Poster Talk: Paula Lang (University of California, Berkeley)
"Revealing structural ensembles hidden in X-ray electron density" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Synthetic/Chemical Biology |
| Discussion Leader: Jeff Peng (University of Notre Dame) |
| 9:05 am - 9:35 am | Stewart Fisher (AstraZeneca)
"Antibacterial Discovery Targeting DNA Replication: Challenges and Opportunities" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Tom Muir (Rockefeller University)
"Exploring Epigenetic Mechanisms Using Chemical Synthesis" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am | Coffee Break |
| 10:45 am - 11:15 am | Alanna Shepartz (Yale University)
"Monitoring sophisticated protein function with profluorescent small molecules" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Joel Schneider (University of Delaware)
"Constructing Useful Biomaterials: Lessons Learned from Proteins" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:20 pm | Poster Talk: Aitziber Cortajarena (Imdea Nanociencia)
"Modulating stability and self-assembly studies of repeat proteins"
|
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Lecture |
| Discussion Leader: Patricia Clark (Notre Dame) |
| 7:30 pm - 7:35 pm | Patricia Clark (Notre Dame)
"Introduction" |
| 7:35 pm - 8:25 pm | David Agard (University of California, San Francisco)
"Conformational Dynamics and Functional Interactions of HSP90 Chaperones" |
| 8:25 pm - 8:40 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
