Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Technological Advances in Protein Science |
| Discussion Leader: Jane Clarke (University of Cambridge, United Kingdom) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 7:55 pm | Introduction by Discussion Leader |
7:55 pm - 8:30 pm | Xiaowei Zhuang (Harvard University, USA) "Illuminating Biology at the Nanoscale with Super-Resolution Imaging" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:45 pm | Introduction by Discussion Leader |
8:45 pm - 9:20 pm | James Wells (University of California, San Francisco, USA) "New Engineered Tools for Signaling" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Recent Advances in Protein Science from Theory to Application |
| Discussion Leader: Jacqui Matthews (The University of Sydney, Australia) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Marius Clore (National Institutes of Health, USA) "Direct Probing of GroEL Foldase Activity by Relaxation-Based NMR Measurements" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Yamuna Krishnan (University of Chicago, USA) "Molecular DNA Devices to Quantitate Protein Activity in Living Cells" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Bertrand Garcia-Moreno (Johns Hopkins University, USA) "Proteins as pH Sensors and Electrostatic Switches" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Wayne Fairbrother (Genentech, Inc., USA) "Internal Motions Prime cIAP1 for Rapid Activation" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Charles Brooks (University of Michigan, USA) "Integrating Protein
Folding and Function in a Bacterial Chaperone: A Multi-Scale Approach to pH,
NMR Chemical Shifts and Chaperone-Substrate Interactions" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolution |
| Discussion Leader: Matthew Cordes (University of Arizona, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:10 pm | Douglas Fowler (University of Washington, USA) "Deep Mutational Scanning to Measure the Impact of Mutations in Proteins on the Molecular and Organismal Level" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Matsuura Tomoaki (Osaka University, Japan) "In Vitro Selection and Evolution of Membrane Proteins" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Eugene Shakhnovich (Harvard University, USA) "How Protein Biophysics Sculpts Fitness Landscapes of Viruses and Bacteria" |
9:15 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Folding |
| Discussion Leader: Susan Marqusee (University of California, Berkeley, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Bruce Bowler (University of Montana, USA) "Twists and Turns on a Folding Landscape" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Elizabeth Meiering (University of Waterloo, Canada) "Folding and Misfolding of Immature SOD1" |
10:05 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Danny Hsu (Academia Sinica, Taiwan) "Structural Basis of Substrate Promiscuity of a Ribosome-Associated Molecular Chaperone" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:25 am | Emanuele Paci (University of Leeds, United Kingdom) "Free Energy Landscapes for Protein Mechanics" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Benjamin Schuler (University of Zurich, Switzerland) "Single-Molecule Spectroscopy of Protein Folding" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Rituparna Sengupta (University of Wisconsin-Madison, USA) "Using Solutes as Probes of Steps and Transition States in Protein Processes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Design |
| Discussion Leader: Liskin Swint-Kruse (The University of Kansas Medical Center, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Stephen Demarest (Eli Lilly & Company, USA) "Protein Folding and Design Applications in Industry: Generating Novel Cancer Therapeutics" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | William Degrado (University of California, San Francisco, USA) "Analysis and Design of Membrane Proteins" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Selected from Poster Abstracts: Katie Digianantonio (Princeton University, USA) "How Do Proteins Designed De Novo Function in Living Cells?" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: Giovanna Ghirlanda (Arizona State University, USA) "Protein-Based Hybrid Catalysts for Hydrogen Production" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Reversible and Irreversible Association |
| Discussion Leader: Josh Wand (University of Pennsylvania, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Danny Hatters (University of Melbourne, Australia) "Quantification of the Protein Folding Capacity of a Cell" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jacqui Matthews (The University of Sydney, Australia) "Strong and Weak Interactions in a Transcriptional Complex" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Rohit Pappu (Washington University in St. Louis, USA) "Functional Consequences of Sequence-to-Conformation Relationships of Intrinsically Disordered Proteins" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Philipp Selenko (Leibniz Institute for Molecular Pharmacology, Germany) "Looking at Proteins in Live cells with Atomic Resolution: From Science Fiction to Science Reality" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Kyle Korshavn (University of Michigan, USA) "The Effects of Zwiterionic Bilayer Thickness upon the Aggregation Structure and Kinetics" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein Interactions and Assembly |
| Discussion Leader: Josh Wand (University of Pennsylvania, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Birthe Kragelund (University of Copenhagen, Denmark) "Motifs in Cellular Hub Associations" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Amy Keating (Massachusetts Institute of Technology, USA) "Designing Selective Peptide Inhibitors of Protein Interactions" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Selected from Poster Abstracts: Joel Mackay (University of Sydney, Australia) "Integrated Structural Analysis of a 1-MDa Chromatin Remodelling Complex" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from Poster Abstracts: David Savage (University of California, Berkeley, USA) "The Self-Assembly and Function of Protein Organelles" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Proteins in Action |
| Discussion Leader: Thomas Magliery (Ohio State University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Karen Fleming (Johns Hopkins University, USA) "The Versatile Beta-Barrel Gives Up Secrets of the Membrane" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Colin Kleanthous (Oxford University, United Kingdom) "How E. coli Got Its Spots" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Lutz Jermutus (MedImmune, United Kingdom) "Teaching Proteases New Tricks: Catalytic Degradation of Abeta and IL-13" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Vic Arcus (University of Waikato, New Zealand) "Macromolecular Rate Theory (MMRT): The Temperature Dependence of Biological Rates from Enzymes to Ecosystems" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Tania Baker (Massachusetts Institute of Technology, USA) "Unexpected Functions of the AAA+ Protein-Unfoldases" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Protein Folding and Proteostasis |
| Discussion Leader: Catherine Royer (University of Montpellier, France) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:10 pm | Jeffery Kelly (The Scripps Research Institute, USA) "Chaperones Can Hasten Folding and Alter the Resulting Structures" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:30 pm | Introduction by Discussion Leader |
8:30 pm - 9:05 pm | Judith Frydman (Stanford University, USA) "Maintaining Cellular Protein Homeostasis in Health and Disease" |
9:05 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |