Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Technology Advances in Protein Science
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Superenzyme Engineering and Biotechnological Applications"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Everyone Needs a Little Help from One's Friends: Synergy Between Solution and Solid State NMR, Cryo-EM and MD Simulations"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"On the Origins of Folded Proteins"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Evolution-Based Design of Proteins"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Thermodynamic Coupling Between Interfaces and the GTPase Switch Encodes the Genotype-to-Phenotype Relationship in Yeast Ran"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"The Role of Conformational Entropy in Molecular Evolution of Bacterial Transcriptional Repressors"
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Insights into Protein Stability, Function and Evolution from Consensus Design"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"'If We Knew What It Was We Were Doing, It Would Not Be Called Research, Would It?' How Following Where the Results Take Us Has Lead to New Understanding of Protein Folding, Misfolding and Assembly"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Incorporating Experimental Data into Long Timescale Simulations of Proteins"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"How Do Cells Know When to Divide? Molecular Mechanisms of Size Control in Budding Yeast"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Structurally Mapping Next-Generation Sequencing Repertoires of Antibodies to Aid In Silico Therapeutic Design"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Automated Design of Antibodies and Enzymes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Engineered Low Molecular Weight Scaffolds in Imaging of Tumors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Biocatalysis: Harnessing the Power of Nature's Tools to Build Complex Molecules"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Ultrahigh Throughput Enzyme Directed Evolution Using Hydrogel Capsules"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"From Protest to Progress Through Partnership: Being Human in STEM"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Nonadiabatic Photodynamics of the Retinal Protonated Schiff Base in Channelrhodopsin 2"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:25 pm
"Engineering Liquid Phase Order from Disordered Proteins"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Functional Interactions of Dysfunctional Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Theoretical Approaches to Protein Phase Separations in Biomolecular Condensates"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Interactions and Assembly
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Exploring the Activation Mechanism and Selective Inhibition of Ubiquitin-Specific Protease 7"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Structure and Dynamics of Peptide Synthetases"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Activation of the Exocyst Tethering Complex for SNARE Complex Regulation and Membrane Fusion"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Conformational Catalysis of Cataract-Associated Aggregation in a Human Eye Lens Crystallin Occurs via Interface Stealing"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Engineering Protein Assemblies with Built-in Allosteric Control Based on Monomer Fold-Switching"
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Embracing Data for the Modeling and Design of Protein-Protein Interactions"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Controlling Protein Motions with Mutation, Temperature and Small Molecules"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Dissecting Allosteric Pathways and Protein Interactions Using Native Mass Spectrometry"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"How Do Molecular Chaperones Coordinate Their Functions?"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Fast, Slow and In-Between: Synonymous Codons Remodel Co-Translational Protein Folding Mechanisms"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"Non-Steric Interactions Predict Protein Stability Trends Inside Cells"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Kinetic Regulation of a Transcription Factor Complex"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Understanding the Mechanism of CaMKII Regulation: From Fertilization to Encoding Long-Term Memory"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"Non-Specific Protein Interactions in Crowded Environments: Weak but Not Without Consequences"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Sustaining Life with Proteins Designed De Novo "
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Giant Protein Assemblies in Nature and by Geometric Design: Emerging Applications"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Processing Proteins
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
"Folding on and off the Ribosome"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
"Evolution of Virus-Like Nucleocapsids from Nonviral Protein Cages"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure