Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Technology Advances in Protein Science
Discussion Leaders: Charles Brooks (University of Michigan, USA) and Elizabeth Meiering (University of Waterloo, Canada)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Taekjip Ha (Johns Hopkins University, USA)
"Superenzyme Engineering and Biotechnological Applications"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Angela Gronenborn (University of Pittsburgh, USA)
"Everyone Needs a Little Help from One's Friends: Synergy Between Solution and Solid State NMR, Cryo-EM and MD Simulations"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Evolution
Discussion Leaders: Eugene Shakhnovich (Harvard University, USA) and Michael Harms (University of Oregon, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Andrei Lupas (Max Planck Institute for Developmental Biology, Germany)
"On the Origins of Folded Proteins"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Rama Ranganathan (University of Chicago, USA)
"Evolution-Based Design of Proteins"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Tina Perica (University of California, San Francisco, USA)
"Thermodynamic Coupling Between Interfaces and the GTPase Switch Encodes the Genotype-to-Phenotype Relationship in Yeast Ran"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Daiana Capdevila (Indiana University, USA)
"The Role of Conformational Entropy in Molecular Evolution of Bacterial Transcriptional Repressors"
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Doug Barrick (Johns Hopkins University, USA)
"Insights into Protein Stability, Function and Evolution from Consensus Design"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Susan Marqusee (California Institute for Quantitative Biosciences (QB3-Berkeley), University of California, Berkeley, USA) and Joan-Emma Shea (University of California, Santa Barbara, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Folding
Discussion Leaders: Shachi Gosavi (National Centre for Biological Sciences, Tata Institute of Fundamental Research, India) and Donald Spratt (Clark University, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Jane Clarke (University of Cambridge, United Kingdom)
"'If We Knew What It Was We Were Doing, It Would Not Be Called Research, Would It?' How Following Where the Results Take Us Has Lead to New Understanding of Protein Folding, Misfolding and Assembly"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Cecilia Clementi (Rice University, USA)
"Incorporating Experimental Data into Long Timescale Simulations of Proteins"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Catherine Royer (Rensselaer Polytechnic Institute, USA)
"How Do Cells Know When to Divide? Molecular Mechanisms of Size Control in Budding Yeast"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineering and Design
Discussion Leaders: Christopher Bahl (Institute for Protein Innovation, USA) and Roberto Chica (University of Ottawa, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Charlotte Deane (University of Oxford, United Kingdom)
"Structurally Mapping Next-Generation Sequencing Repertoires of Antibodies to Aid In Silico Therapeutic Design"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Sarel Fleishman (Weizmann Institute of Science, Israel)
"Automated Design of Antibodies and Enzymes"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Daša Lipovšek (Bristol-Myers Squibb, USA)
"Engineered Low Molecular Weight Scaffolds in Imaging of Tumors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Alison Narayan (University of Michigan, USA)
"Biocatalysis: Harnessing the Power of Nature's Tools to Build Complex Molecules"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Michael Nash (University of Basel / ETH Zurich, Switzerland)
"Ultrahigh Throughput Enzyme Directed Evolution Using Hydrogel Capsules"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Sheila Jaswal (Amherst College, USA)
"From Protest to Progress Through Partnership: Being Human in STEM"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Solvation and Phases
Discussion Leaders: Andrea Soranno (Washington University in St. Louis, USA) and Jacqui Matthews (The University of Sydney, Australia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Ruibin Liang (Stanford University, USA)
"Nonadiabatic Photodynamics of the Retinal Protonated Schiff Base in Channelrhodopsin 2"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:25 pm
Cliff Brangwynne (Princeton University, USA)
"Engineering Liquid Phase Order from Disordered Proteins"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Elizabeth Rhoades (University of Pennsylvania, USA)
"Functional Interactions of Dysfunctional Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Hue Sun Chan (University of Toronto, Canada)
"Theoretical Approaches to Protein Phase Separations in Biomolecular Condensates"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Interactions and Assembly
Discussion Leaders: Tamara Bidone (Scientific Computing and Imaging Institute, University of Utah , USA) and Gabriel Rocklin (Northwestern University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Erin Dueber (Genentech, USA)
"Exploring the Activation Mechanism and Selective Inhibition of Ubiquitin-Specific Protease 7"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
Martin Schmeing (McGill University, Canada)
"Structure and Dynamics of Peptide Synthetases"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Mary Munson (University of Massachusetts Medical School, USA)
"Activation of the Exocyst Tethering Complex for SNARE Complex Regulation and Membrane Fusion"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Eugene Serebryany (Harvard University, USA)
"Conformational Catalysis of Cataract-Associated Aggregation in a Human Eye Lens Crystallin Occurs via Interface Stealing"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Victor Muñoz (University of California, Merced, USA)
"Engineering Protein Assemblies with Built-in Allosteric Control Based on Monomer Fold-Switching"
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Amy Keating (Massachusetts Institute of Technology, USA)
"Embracing Data for the Modeling and Design of Protein-Protein Interactions"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Binding and Allostery
Discussion Leaders: John Karanicolas (Fox Chase Cancer Center, USA) and Kathryn McMenimen (Mount Holyoke College, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
James Fraser (University of California, San Francisco, USA)
"Controlling Protein Motions with Mutation, Temperature and Small Molecules"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Amnon Horovitz (Weizmann Institute of Science, Israel)
"Dissecting Allosteric Pathways and Protein Interactions Using Native Mass Spectrometry"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Timothy Street (Brandeis University, USA)
"How Do Molecular Chaperones Coordinate Their Functions?"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Patricia Clark (University of Notre Dame, USA)
"Fast, Slow and In-Between: Synonymous Codons Remodel Co-Translational Protein Folding Mechanisms"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteins in Cells
Discussion Leaders: Lila Gierasch (University of Massachusetts Amherst, USA) and Bruno Correia (Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Switzerland)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Caitlin Davis (University of Illinois at Urbana-Champaign, USA)
"Non-Steric Interactions Predict Protein Stability Trends Inside Cells"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Jacqui Matthews (The University of Sydney, Australia)
"Kinetic Regulation of a Transcription Factor Complex"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Margaret Stratton (University of Massachusetts Amherst, USA)
"Understanding the Mechanism of CaMKII Regulation: From Fertilization to Encoding Long-Term Memory"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
Michael Feig (Michigan State University, USA)
"Non-Specific Protein Interactions in Crowded Environments: Weak but Not Without Consequences"
11:00 am - 11:10 am
Discussion
11:10 am - 11:40 am
Michael Hecht (Princeton University, USA)
"Sustaining Life with Proteins Designed De Novo "
11:40 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Todd Yeates (University of California, Los Angeles, USA)
"Giant Protein Assemblies in Nature and by Geometric Design: Emerging Applications"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Processing Proteins
Discussion Leaders: Joan-Emma Shea (University of California, Santa Barbara, USA) and Josh Wand (University of Pennsylvania, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
Susan Marqusee (California Institute for Quantitative Biosciences (QB3-Berkeley), University of California, Berkeley, USA)
"Folding on and off the Ribosome"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
Donald Hilvert (ETH Zurich, Switzerland)
"Evolution of Virus-Like Nucleocapsids from Nonviral Protein Cages"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure