Sunday, July 9, 2000
Session 1: (7:30-9:45 p.m.) | Emerging Model Systems in Proteoglycan Research |
Discussion Leaders: Jeffrey Esko and Ulf Lindhal
- Norbert Perrimon: Drosophila tout velu (EXT) gene in hedgehog signaling
- Joshua Rubin: Heparan sulphate proteoglycans modulate Sonic hedgehog-induced proliferation of cerebellar granule cells
- Scott Saunders: Glypican-3 controls cellular responses to BMP4 in limb patterning and skeletal development
- Donald Moerman: Complex pattern of alternatively splicing of perlecan in C. Elegans
- Mauro Pavao: Occurence of heparin in the invertebrate Styela Plicata (Tunicata) is restricted to cell layers facing the outside environment: an ancient role in defense?
Monday, July 10, 2000
Session 2: (9:00-12:30 a.m.) | Proteoglycan Biosynthesis and Assembly |
Discussion Leaders: Lena Kjellén and Koji Kimata
- Nick Shworak: Heparan sulfate: structure in search of biology - biology in search of structure
- Carlos Hirschberg/Patricia Berninsone: Novel regulation of glyconjugate biosynthesis
- Peter H. Seeberger: A general, highly convergent, and modular synthesis of heparin-like glycosaminoglycan oligosaccharides
- Kay Grobe: Molecular properties of the four members of teh heparan sulfate/heparin GlcNAc N-deacetylase/M-sulfotransferase family
- Osami Habuchi: Molecular cloning and characterization of chondroitin 4-sulfotransferase
- Kazuyuki Sugahara: The biosynthesis of the glycosaminoglycan-protein linkage region
- Sally Stringer: Heparin in the brain
- Scott Guimond: Dynamic expression of heparan sulfate biosynthetic enzymes in developing mouse brain
- Hans Kresse: Influence of core protein on glycosaminoglycan chain attachment and glucuronic acid epimerization in chondroitin/dermatan sulfate proteoglycans
Monday, July 10, 2000
Session 3: (7:30-9:45 p.m.) | Heparin and Heparan Sulfate in Cell Biology and Development |
Discussion Leaders: Rick Stevens and John Hassell
- Erik Forsberg: N-deacetylase/N-sulfotransferase-1 knockout
- Donald Humphreis: Generation of N-deacetylase/N-sulfotransferase-2-null mice to elucidate the function of heparin
- Kevin Williams: A novel role for the heparan sulfate N-deaccetylase/M-sulfotransferase-1 in diabetic complications
- Charles Emerson: Identification of a novel extracellular N-acetylglucosamine 6-sulfatase required for myoD activation in avian somites
- Maria Pinhal: Infrastructure of teh enzymes involved in heparan sulfate biosynthesis
- Yoshi Yamada: Role of perlecan in mammalian development
Tuesday, July 11, 2000
Session 4: ( 9:00-12:30 a.m.) | The Biology of Hyaluronan and Its Receptors |
Discussion Leaders: Brian Toole and Cheryl Knudson
- Paul Noble: CD44-/- mice have altered hyaluronan turnover and persistent inflammation following lung injury
- Raja Tammi: Role of CD44 in the catabolism of hyaluronan in keratinocytes
- Paul H. Weigel: Identification of HARE, the hyaluronian receptor for endocytosis
- Anthony J. Day: Determination of the hyaluronian binding site on human TSG-6
- Carol de la Motte: The role of hyaluronan in inflammatory bowel disease
- Ivan Stamenkovic: Mechanisms of CD44-mediated tumor invasion and angiogenesis
- Paul L. DeAngelis: Two active sites exist in the Pasteurella multocida hyaluronian synthase
Tuesday, July 11, 2000
Session 5: (7:30-9:45 p.m.) | Protein-Glycosaminoglycan Interactions |
Discussion Leaders: Anna Plaas and John Gallagher
- Robert Linhardt: Overview of heparin/protein interactions
- David Stuart: Structural basis of heparan sulfate/virus interactions
- Ganesh Venkataraman: Specific conformational changes in heparin/heparan sulfate-like glycosaminoglycans resulting in a "kink" when bound to proteins
- Toin van Kuppevelt: Phage display derived antibodies to heparan sulfate: new tools for studying proteoglycans
- Jim San Antonio: Design of peptides with high affinities for heparin and endothelial cell proteoglycans
- Catherine Merry: Analysis of the altered structure and growth factor binding properties of heparan sulfate chains from mice homozygous for a gene trap mutation in the gene encoding HS 2-O-sulfotransferase
Wednesday, July 12, 2000
Session 6: (9:00-12:30 a.m.) | Proteoglycan/Growth Factor Interactions and Signaling |
Discussion Leaders: Anne Woods and Paul Goetinck
- Eva Turley: Hyaluronan receptors and cell signaling
- John McDonald: A hyaluronan-dependent signaling mechanism involving Ras activation
- Maryse Delehedde: Regulation by heparan sulfate of signaling by FGF2 and HGF in mammary cells
- Malcolm Lyon: The specificity and role of proteoglycans in the regulation of hepatocyte growth factor
- Matthew Nugent: Heparan sulfate proteoglycans control FGF transport and intracellular processing
- John Couchman: Oligomerization and signaling through syndecan-4
- John Lincecum: Conservation of function in syndecans: Drosophila syndecan and murine syndecan-1 cytoplasmic domains are required for changes in epithelial morphology
- Ralph D. Sanderson: The ectodomain core protein of syndecan-1 participates in generating signals that promote cell spreading
Wednesday, July 12, 2000
Session 7: (7:30-9:45 p.m.) | The Biology of Small Leucine-Rich Proteoglycans |
Discussion Leaders: Marian Young and Shukti Chakravarti
- David McQuillan: Structural requirements for functional small leucine-rich proteoglycans
- Elke Schoenherr: Decorin as a mediator of angiogenesis
- Lari Hakkinen: A role for decorin in the structural organization of periodontal ligaments
- Paul N. Bishop: Opticin, a new member of the small leucine-rich proteoglycan gene family
- Justin Fallon: The role of biglycan in MuSK signaling and muscular dystrophy
- Winston Kao: Overexpression of buglycan induces ocular surface disorders in Ktcnpr-BGLN transgenic mice
Thursday, July 13, 2000
Session 8: (9:00-12:30 a.m.) | Proteoglycans in Disease States |
Discussion Leaders: Bruce Caterson and Amanda Fosang
- Tom Wight: Cell-mediated proteoglycan gene transfer alters the development of vascular lesions
- Jan Borén: Proteoglycan- binding defective LDL in the initiation of atherosclerosis
- Steven D. Rosen: Endoglycan, a novel sialomucin/proteoglycan on endothelial cells
- Bryan P. Toole: Hyaluronan oligosaccharides and soluble CD44 inhibit anchorage-independent growth of tumor cells
- Murray Korc: The role of glypican in the pathobiology of cancer
- Frank Tufaro: EXT genes in hereditary bone tumors
- Roberto Perris: Versican in tumor progression and neoangiogenesis
- Anna Bassols: Versican expression in human melanoma
Thursday, July 13, 2000
Session 9: (7:30-9:45 p. m.) | Microbial Interactions and Therapeutics |
Discussion Leader: Magnus Höök and Vincent Hascall
- Pat Spear: Herpes simplex virus/heparan sulfate interactions
- Glenn Prestwitch: Drug delivery in wound healing using hydrogel films
- Michael Kinsella: Retrovirally-mediated overexpression of decorin in bovine aortic endothelial cells inhibits cell migration and increases fibrillar matrix assembly
- Urs Rutishauser: Polysialic acid, transition from the fly to Albert Einstein
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