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Proteoglycans

Gordon Research Conference

Discovery and Translation in Proteoglycan Research

July 7 - 12, 2024

Chairs

and

Vice Chairs

and

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Proteoglycans GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Proteoglycans" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Proteoglycans in Health and Disease Discussion Leaders: and
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Studying Cell Surface GlycoRNAs and HSPGs"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Drug Discovery for Sanfilippo Syndrome"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Advancing Glycosaminoglycan Analysis: Utilizing ¹³C-Labeled Internal Standards"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Halofuginone-Mediated Repression of Heparan Sulfate Limits Hepcidin and Alters Iron Metabolism"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"UGDH D379N is A Unique Clinical Mutation that Eliminates Enzyme Activity and Induces Developmental Dysfunction"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Proteoglycan and Glycosaminoglycan Biosynthesis Discussion Leaders: and
9:00 am - 9:20 am	"Targeting Heparan Sulfate Assembly in Rare Disease"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Heparan Sulfate Biosynthesis, Cellular Functions and Clinical Implications in Gastric Cancer"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Genome-wide Regulation of Exostosin-1/2 for Drug Target Discovery in Multiple Hereditary Exostoses (MHE)"
9:55 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Decoding the Initial Steps of Glycosaminoglycan Biosynthesis"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Sulfs: A Pivotal Role in The Post-Synthesis Regulation Heparan Sulfate?"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Investigating Heparan Sulphate Biosynthesis in Situ by Cryo-Electron Tomography"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Cell-Based Libraries of Glycosaminoglycans for Technology Development"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Proteoglycan and Glycosaminoglycan Signalling in Development, Stem Cells and the Stem Cell Niche Discussion Leaders: and
7:30 pm - 7:50 pm	"Cell-Extrinsic Syndecan-2 Promotes Hematopoietic Stem Cell Self-Renewal"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Molecular Regulation of HSPG Interactions Through Adult Neurogenesis"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Evolution of SARS-CoV-2 Spike Protein Towards Optimized Heparan Sulfate Cross-Linking and Inter-Chain Mobility"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"The Use of ToF-SIMS to Identify In-Situ Compensatory GAG Behaviours."
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"The Role of Perlecan (HSPG2) In The Development of Human Cardiomyocytes"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Human Disorders of Glycosaminoglycan and Proteoglycan Biosynthesis and Breakdown Discussion Leaders: and
9:00 am - 9:20 am	"Congenital Disorders Caused by Mutations in Glycosaminoglycan Biosynthetic Enzymes As Well As A Calcium-Dependent Nucleotidase"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Knockout of the Intellectual Disability-Linked Gene Hs6st2 in Mice Impairs Neuronal Spines and Affects Memory"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Inherited Glycosaminoglycan Biosynthesis Disorders: Identification of Novel Monogenic Disease Genes Using HS2ST1 as Example"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Peptide Based Inhibition of Biglycan Binding to TLR2/4"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Proteoglycans and in vitro Models of Human Neurogenesis"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Heparanase 2 - A Novel Regulator of Vascular Homeostasis"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Proteoglycans and Glycosaminoglycans in Inflammation and Sepis Discussion Leaders: and
7:30 pm - 7:50 pm	"Using Randomized Controlled Trials To Study Endothelial Glycocalyx Degradation during Human Sepsis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"IL-13 as a Modulator of the Hyaluronan Matrix during Lung Inflammation and Injury."
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Kinetic and Structural Aspects of Glycosaminoglycan-Viral Protein Interactions using SPR Biosensor"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Regulation of Hemostasis by Endothelial Glycocalyx Heparan Sulfate"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Heparan Sulfate on the Surface of Immune Cells Regulates their Migration into Skin During Psoriasis-Like Skin Inflammation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Immune Regulation Mediated by Protein-Carbohydrate Interactions"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Applications of Glycosaminoglycans and Proteoglycans in (Bio)engineering Discussion Leaders: and
9:00 am - 9:20 am	"Decorin: A Central Player of Cartilage Extracellular Matrix in Health and Disease"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Genome Wide CRISPR Screening to Bioengineer a Safer, Recombinant Heparin"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Solid-State Nanopore Analysis of Hyaluronan and its Heavy Chain-Modification as a Biomarker of Disease"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Targeting Inflammation in Influenza A Infection with Synthetic Heparan Sulfate"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 10:55 am	"Chemoenzymatic Synthesis of Biologically Active Heparan Sulfate Oligosaccharides Library"
10:55 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Revealing Complexity of Glycosaminoglycan/Effector Protein Interactions in The Extracellular Space – Tools and Insights"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Developing Heparan Sulphate Media Additives Through Metabolic Engineering for Mesenchymal Stromal Cell Expansion"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Glycosaminoglycan-Based Niche Affects Tissue Specific Differentiation of Human Mesenchymal Stem Cells (hMSCs)"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Aggrecan Gene Variants in Familial Osteochondritis Ossecans - Proteomic Analysis of a Mouse Model and Patients"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Glycosaminoglycans and Proteoglycans in Cancer Diagnosis and Treatment Discussion Leaders: and
7:30 pm - 7:50 pm	"Unexpected Functional Role of Chondroitin Sulfate in Brain Tumors Opens Avenues for New Treatment Concepts"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Pten-loss Upregulates CREB-Heparan Sulfate-FGF Signaling to Promote Prostate Tumorigenesis and Targeting the Signaling Axis for Therapy"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Proteoglycans as Important Signaling Molecules in The Crosstalk Between Tumor Infiltrating Immune Cells and Cancer Cells"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"The Non-Canonical EZH2/TRIM28/SULF1 Axis Mediates Heparan Sulfate Assembly and Melanoma Cell Growth"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Role of Syndecan-1 in Breast Cancer Radiotherapy Resistance"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Machine Learning, AI, Large Data and GAGs Discussion Leaders: and
9:00 am - 9:20 am	"Spotting The Differences in GAGs Within Tissue: Using Secondary Ion Mass Spectrometry to Assess GAGs within Biological Samples"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"The Role of Extracellular Landscape in Germ Cell Fate in Vivo"
9:40 am - 9:45 am	Discussion
9:45 am - 10:05 am	"The Use of Big Data Sets to Understand Better the Nature of the Versican/Hyaluronan Matrix"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Heparan Sulfate 6-O-Sulfation in Brain Functions"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Accelerating Cancer Diagnosis and Therapeutic Development Through Machine Learning"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Characterization of Crude Heparin Composition and Structural Characteristics Using Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy."
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Predicting the Risk of Any-Type Cancer in Asymptomatic Adults Using Noninvasive Glycosaminoglycan Profiling"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Novel Applications of Glycosaminoglycans and Proteoglycans Discussion Leaders: and
7:30 pm - 7:50 pm	"Sustainable Sourcing and Scale-Up Purification of Mollusk-Derived Heparan Sulfate: A Potent Inhibitor of Tumor Metastasis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Functional Spatial Metabolic Triple-Omics to Study Pulmonary Fibrosis"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Nidogen-1 and Decorin Restore Functionality of Human Islets of Langerhans in Hypoxic Conditions"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Unlocking Adipocyte Heparan Sulfate Regulation of FGF1 Signaling to Tackle Type-2 Diabetes"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Renato Iozzo

Research reported in this publication was supported by the National Institute Of Arthritis And Musculoskeletal And Skin Diseases of the National Institutes of Health under Award Number R13AR084288. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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