Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Proteoglycans in Health and Disease
Discussion Leaders: Anthony Day (University of Manchester, United Kingdom) and Meg Critcher (Scripps Research, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Ryan Flynn (Boston Children's Hospital, United States)
"Studying Cell Surface GlycoRNAs and HSPGs"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Amrita Basu (University of Georgia, United States)
"Drug Discovery for Sanfilippo Syndrome"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Zhangjie Wang (Glycan Therapeutics LLC, United States)
"Advancing Glycosaminoglycan Analysis: Utilizing 13 C-Labeled Internal Standards"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Stephanie Leal (UC San Diego, United States)
"Halofuginone-Mediated Repression of Heparan Sulfate Limits Hepcidin and Alters Iron Metabolism"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Hali Harwood (NC State University , United States)
"UGDH D379N is A Unique Clinical Mutation that Eliminates Enzyme Activity and Induces Developmental Dysfunction"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteoglycan and Glycosaminoglycan Biosynthesis
Discussion Leaders: Lena Kjellen (Uppsala University, Sweden) and Jessica Oyie Onyeisi (University of Münster, Germany)
9:00 am - 9:20 am
Ryan Weiss (University of Georgia, United States)
"Targeting Heparan Sulfate Assembly in Rare Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Ana Magalhaes (i3S-Institute for Research and Innovation in Health, University of Porto, Portugal)
"Heparan Sulfate Biosynthesis, Cellular Functions and Clinical Implications in Gastric Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Xiaolin Dong (University of Georgia, United States)
"Genome-wide Regulation of Exostosin-1/2 for Drug Target Discovery in Multiple Hereditary Exostoses (MHE)"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rebekka Wild (CNRS / Institut de Biologie Structurale Grenoble, France)
"Decoding the Initial Steps of Glycosaminoglycan Biosynthesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Romain Vives (CNRS, France)
"Sulfs: A Pivotal Role in The Post-Synthesis Regulation Heparan Sulfate?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Courtney Mycroft-West (The Rosalind Franklin Institute, United Kingdom)
"Investigating Heparan Sulphate Biosynthesis in Situ by Cryo-Electron Tomography"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Rebecca Miller (University of Copenhagen, Denmark)
"Cell-Based Libraries of Glycosaminoglycans for Technology Development"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Christina Termini (Fred Hutchinson Cancer Center, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycan and Glycosaminoglycan Signalling in Development, Stem Cells and the Stem Cell Niche
Discussion Leaders: Sandeep Gopal (Lund University, Sweden, Sweden) and Andrea Vortkamp (University of Duisburg-Essen, Germany)
7:30 pm - 7:50 pm
Christina Termini (Fred Hutchinson Cancer Center, United States)
"Cell-Extrinsic Syndecan-2 Promotes Hematopoietic Stem Cell Self-Renewal"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Martina Gyimesi (QUT, Australia)
"Molecular Regulation of HSPG Interactions Through Adult Neurogenesis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Kay Grobe (University of Muenster, Germany)
"Evolution of SARS-CoV-2 Spike Protein Towards Optimized Heparan Sulfate Cross-Linking and Inter-Chain Mobility"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Lorna Milne (The University of Nottingham, United Kingdom)
"The Use of ToF-SIMS to Identify In-Situ Compensatory GAG Behaviours."
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
James Smith (University of East Anglia, United Kingdom)
"The Role of Perlecan (HSPG2) In The Development of Human Cardiomyocytes"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Human Disorders of Glycosaminoglycan and Proteoglycan Biosynthesis and Breakdown
Discussion Leaders: Fransiska Malfait (Ghent University Hospital, Belgium) and Neil Patel (University of Georgia, United States)
9:00 am - 9:20 am
Shuhei Yamada (Meijo University, Japan)
"Congenital Disorders Caused by Mutations in Glycosaminoglycan Biosynthetic Enzymes As Well As A Calcium-Dependent Nucleotidase"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Sohyun Moon (New York Institute of Technology (NYIT), United States)
"Knockout of the Intellectual Disability-Linked Gene Hs6st2 in Mice Impairs Neuronal Spines and Affects Memory"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Kerstin Kutsche (University Medical Center Hamburg-Eppendorf, Germany)
"Inherited Glycosaminoglycan Biosynthesis Disorders: Identification of Novel Monogenic Disease Genes Using HS2ST1 as Example"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Liliana Schaefer (University of Frankfurt, Germany)
"Peptide Based Inhibition of Biglycan Binding to TLR2/4"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Larisa Haupt (Queensland University of Technology, Australia)
"Proteoglycans and in vitro Models of Human Neurogenesis"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Yannic Becker (Mount Desert Island Biological Laboratory, Hannover Medical School Germany, United States)
"Heparanase 2 - A Novel Regulator of Vascular Homeostasis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycans and Glycosaminoglycans in Inflammation and Sepis
Discussion Leaders: Kenton Arkill (University of Nottingham, United Kingdom) and Aaron Petrey (University of Utah, United States)
7:30 pm - 7:50 pm
Eric Schmidt (Massachusetts General Hospital, United States)
"Using Randomized Controlled Trials To Study Endothelial Glycocalyx Degradation during Human Sepsis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Rebecca Dodd (University of Manchester, United Kingdom)
"IL-13 as a Modulator of the Hyaluronan Matrix during Lung Inflammation and Injury."
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Fuming Zhang (Rensselaer Polytechnic Institute, United States)
"Kinetic and Structural Aspects of Glycosaminoglycan-Viral Protein Interactions using SPR Biosensor"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Kaori Oshima (Massachusetts General Hospital, United States)
"Regulation of Hemostasis by Endothelial Glycocalyx Heparan Sulfate"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Megan Priestley (University of Manchester, United Kingdom)
"Heparan Sulfate on the Surface of Immune Cells Regulates their Migration into Skin During Psoriasis-Like Skin Inflammation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Fikri Avci (Emory University School of Medicine, United States)
"Immune Regulation Mediated by Protein-Carbohydrate Interactions"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Applications of Glycosaminoglycans and Proteoglycans in (Bio)engineering
Discussion Leaders: Glenn Prestwich (Clear Solutions Biomedical, United States) and Brooke Farrugia (University of Melbourne, Australia)
9:00 am - 9:20 am
Lin Han (Drexel University, United States)
"Decorin: A Central Player of Cartilage Extracellular Matrix in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Jack Moore (University of Georgia, United States)
"Genome Wide CRISPR Screening to Bioengineer a Safer, Recombinant Heparin"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Dorothea Erxleben (Wake Forest University School of Medicine, United States)
"Solid-State Nanopore Analysis of Hyaluronan and its Heavy Chain-Modification as a Biomarker of Disease"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Katelyn Arnold (Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, United States)
"Targeting Inflammation in Influenza A Infection with Synthetic Heparan Sulfate"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Scott Guimond (Centre for Glycoscience - Keele University, United Kingdom)
"Chemoenzymatic Synthesis of Biologically Active Heparan Sulfate Oligosaccharides Library"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Ralf Richter (University of Leeds, United Kingdom)
"Revealing Complexity of Glycosaminoglycan/Effector Protein Interactions in The Extracellular Space – Tools and Insights"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Raymond Smith (The University of Queensland, Australia)
"Developing Heparan Sulphate Media Additives Through Metabolic Engineering for Mesenchymal Stromal Cell Expansion"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Barbara CHAN (CUHK, Hong Kong SAR China)
"Glycosaminoglycan-Based Niche Affects Tissue Specific Differentiation of Human Mesenchymal Stem Cells (hMSCs)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Anders Aspberg (Lund University, Sweden)
"Aggrecan Gene Variants in Familial Osteochondritis Ossecans - Proteomic Analysis of a Mouse Model and Patients"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycosaminoglycans and Proteoglycans in Cancer Diagnosis and Treatment
Discussion Leaders: Renato Iozzo (Thomas Jefferson University, United States) and Erica Peterson (Virginia Commonwealth University, United States)
7:30 pm - 7:50 pm
Anna Bång-Rudenstam (Lund University, Department of Clinical Sciences, Section of Oncology, Sweden)
"Unexpected Functional Role of Chondroitin Sulfate in Brain Tumors Opens Avenues for New Treatment Concepts"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Lianchun Wang (University of South Florida, United States)
"Pten-loss Upregulates CREB-Heparan Sulfate-FGF Signaling to Promote Prostate Tumorigenesis and Targeting the Signaling Axis for Therapy"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Erik Knutsen (UiT The Arctic University of Norway, Norway)
"Proteoglycans as Important Signaling Molecules in The Crosstalk Between Tumor Infiltrating Immune Cells and Cancer Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Neil Patel (University of Georgia, United States)
"The Non-Canonical EZH2/TRIM28/SULF1 Axis Mediates Heparan Sulfate Assembly and Melanoma Cell Growth"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Martin Gotte (Münster University Hospital, Germany)
"Role of Syndecan-1 in Breast Cancer Radiotherapy Resistance"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Machine Learning, AI, Large Data and GAGs
Discussion Leaders: Kamil Godula (University of California, San Diego, United States) and Courtney Mycroft-West (The Rosalind Franklin Institute, United Kingdom)
9:00 am - 9:20 am
Andrew Hook (University of Nottingham, United Kingdom)
"Spotting The Differences in GAGs Within Tissue: Using Secondary Ion Mass Spectrometry to Assess GAGs within Biological Samples"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Sandeep Gopal (Lund University, Sweden, Sweden)
"The Role of Extracellular Landscape in Germ Cell Fate in Vivo"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Charles Frevert (University of Washington School of Medicine, United States)
"The Use of Big Data Sets to Understand Better the Nature of the Versican/Hyaluronan Matrix"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Yingtao Zhao (New York Institute of Technology, United States)
"Heparan Sulfate 6-O-Sulfation in Brain Functions"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Melanie Simpson (North Carolina State University, United States)
"Accelerating Cancer Diagnosis and Therapeutic Development Through Machine Learning"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Mark Skidmore (Centre for Glycoscience - Keele University, United Kingdom)
"Characterization of Crude Heparin Composition and Structural Characteristics Using Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy."
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Francesco Gatto (Elypta, Sweden)
"Predicting the Risk of Any-Type Cancer in Asymptomatic Adults Using Noninvasive Glycosaminoglycan Profiling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Applications of Glycosaminoglycans and Proteoglycans
Discussion Leaders: Kimberly Alonge (University of Washington, United States) and Joseph Hippensteel (University of Colorado Anschutz Medical Campus, United States)
7:30 pm - 7:50 pm
Mauro Pavao (Federal University of Rio de Janeiro, Brazil)
"Sustainable Sourcing and Scale-Up Purification of Mollusk-Derived Heparan Sulfate: A Potent Inhibitor of Tumor Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ramon Sun (university of florida, United States)
"Functional Spatial Metabolic Triple-Omics to Study Pulmonary Fibrosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Katja Schenke-Layland (NMI Natural and Medical Sciences Institute at the University Tübingen, Germany)
"Nidogen-1 and Decorin Restore Functionality of Human Islets of Langerhans in Hypoxic Conditions"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Phillip Gordts (University of California, San Diego, United States)
"Unlocking Adipocyte Heparan Sulfate Regulation of FGF1 Signaling to Tackle Type-2 Diabetes"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure