Structure, Mechanisms, and Applications of Proteoglycans in Health and Disease

July 7 - 8, 2018

Chairs

and

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Proteoglycans is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The GRS is a small group setting that fosters open discussion about innovative research through formal presentation and social interaction. The Proteoglycans GRS will cover topics related to the functional aspects of proteoglycans and their regulatory roles in cellular processes. The meeting will address basic research questions about biosynthesis and structure of proteoglycans, their effect on signaling and other processes in development and disease, as well as therapeutic and translational applications.

The GRS will also feature a career panel session during which mentors at various stages of their careers will share experiences and answer career-focused questions from the trainees.

The Proteoglycans GRS will be held in conjunction with the Gordon Research Conference on Proteoglycans, and we encourage applicants to submit abstracts to both meetings.

Related Meeting

This GRS will be held in conjunction with the "Proteoglycans" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	The Dynamic Remodeling of Proteoglycans Discussion Leaders: and
3:45 pm - 3:55 pm	"The Recognition of Heparan Sulfate by Extracellular Endosulfatase HSulf2: A Cooperative Hunting Process"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 4:10 pm	"Downregulation of Sulfatase-1 in Pulmonary Endothelial Cells Contributes to Post-Septic Compensatory Anti-Inflammatory Response Syndrome"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Cancer Cell-Surface Proteoglycan Expression Remodeling in the Acidic Tumor Niche: Implications for Proteoglycan-Dependent Uptake of Extracellular Vesicles and Lipoproteins"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Proteoglycans as Extracellular Regulators of Cell Behavior Discussion Leaders: and
7:30 pm - 7:40 pm	"Self-Assembling Peptide Hydrogels as Fully-Defined, Tuneable Matrix Environments for Dissecting the Roles of Matrix Components in Disease"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Characterizing the Interaction Between rVAR2 and ofCS: A Novel Glycosaminoglycan Cancer Specific Biomarker"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Assignment of C-5 Uronic Acid Stereochemistry in Synthetic Heparan Sulfate Glycosaminoglycan Hexasaccharides by Electron Detachment Dissociation"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Role of Hyaluronan in Perinatal White Matter Injury"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Down-Regulation of UDP-Glucose Dehydrogenase Affects Epirubicin Response and Extracellular Matrix Components in MDA-MB-231 Breast Cancer Cells"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Regulation of Macrophage Heparan Sulfate Proteoglycans in Rheumatoid Arthritis and Other Chronic Inflammatory Diseases"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"SLC10A7 Mutations in Human and Mouse Cause a Skeletal Dysplasia with Amelogenesis Imperfecta Mediated by GAG Biosynthesis Defects"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Expression and Function of Human Macrophage Heparan Sulphate Proteoglycans"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Disease and Therapeutic Opportunities Discussion Leaders: and
9:00 am - 9:15 am	"HSPG-Mediated Extracellular Vesicle Internalization by Cancer Cells: Influence of Tumor Hypoxia and Heparin Affinity EV Surface Proteome Characterization"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Role of Oncofetal Chondroitin Sulfate in Tumorigenesis and Antitumor Immunity"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Use of Glycans to Prevent Intracellular Heparan Sulfate Degradation in Sanfilippo Syndrome"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Patch Grafting Strategies for Transplantation of Stem/Progenitors into Internal Organs"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Heparan Sulfate Alterations of Importance for Brain Tumor Development"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Knockdown and Knockout Zebrafish Models for the β4GalT7-Deficient Type of Ehlers-Danlos Syndrome Reveal Distinctive and Overlapping Phenotypic Features"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Heparan Sulfate Modulates Liver Damage and Mortality During MRSA Sepsis"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career Panel This career panel consists of new, mid-career, and senior investigators with experience in academia and industry. Designed as a forum to share experiences, provide unique perspectives, and answer questions from trainees. Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Successful Paths in Proteoglycan Science
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by (1 R13AR073613-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Proteoglycans

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