SATURDAY |
1:30 pm - 4:30 pm | Arrival and Check-in |
3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:15 pm - 4:00 pm | Cathepsin Proteases At The Cutting Edge Of Cancer |
3:15 pm - 3:45 pm | Johanna Joyce (Memorial Sloan Kettering Cancer Center)
"Cathepsin proteases at the cutting edge of cancer"
|
3:45 pm - 4:00 pm | Discussion |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Cancer, Cathepsins and Legumain |
| Discussion Leaders: Daniel Sojka (Institute of Parasitology, BC ASCR) and Leila Akkari (Memorial Sloan Kettering Cancer Center)
|
5:30 pm - 5:50 pm | Elfriede Dall (University of Salzburg)
"The crystal structure of legumain discloses orthogonal mechanisms of activity regulation and substrate recognition"
|
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Kingsley Osuala (Wayne State University)
"A Paracrine Cytokine/Chemokine Pathway through CCL20 in Progression of Ductal Carcinoma in Situ to Invasive Ductal Carcinoma"
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6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Stephanie Dauth (Jacobs University)
"Structural and functional alterations in the central nervous system of mice lacking cathepsin K" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Daniela Loessner (Queensland University of Technology)
"Kallikrein proteases are key players in the ovarian tumour-stroma microenvironment"
|
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:00 am | Probing Protease Specificity and Activation |
| Discussion Leaders: Dion Kaiserman (Monash University) and Maria Arampatzidou (Jacobs University)
|
9:00 am - 9:20 am | Bernhard Lechtenberg (University of Cambridge)
"GpIba-Thrombin Interactions Probed by NMR Spectroscopy and X-ray Crystallography"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Marcin Poreba (Wroclaw University)
"Fluorogenic substrate libraries with unnatural amino acids as tools for investigation of important human cysteine proteases"
|
9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Julie Zorn (University of California, San Francisco)
"Activation of Executioner Procaspases"
|
9:55 am - 10:00 am | Discussion |
10:00 am - 11:00 am | "A Small World", A Career Mentorship Panel Showcasing International training And Career Development |
| Johanna Joyce (Memorial Sloan Kettering Cancer Center), James Whisstock (Monash University), and Margarete Heck (University of Edinburgh)
|
11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Proteases in Infectious Diseases and Immunity |
| Discussion Leaders: Laura Edgington (Stanford University) and Daniel Hargbøl Madsen (Copenhagen University Hospital)
|
1:30 pm - 1:50 pm | Eva Huber (Technische Universität München)
"Crystal structures of the mouse constitutive and immunoproteasome"
|
1:50 pm - 2:00 pm | Discussion |
2:00 pm - 2:10 pm | Randy Kipp (Albert Einstein College of Medicine)
"Transition states and dynamics of HIV-1 protease"
|
2:10 pm - 2:15 pm | Discussion |
2:15 pm - 2:25 pm | Sabrina Mueller (Institute of Molecular Medicine and Cell Research)
"Role of lysosomal cysteine cathepsins in the macrophage response to Staphylococcus aureus"
|
2:25 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |