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Proteolytic Enzymes and Their Inhibitors (GRS)

Gordon Research Seminar

The Regulation of Proteolysis in Health, Disease and Treatment

June 4 - 5, 2022

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Proteolytic Enzymes and Their Inhibitors is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is the regulation of proteolysis in health, disease and treatment.

Related Meeting

This GRS will be held in conjunction with the "Proteolytic Enzymes and Their Inhibitors" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm	Keynote Session: Proteases in Life and Disease Discussion Leader:
3:15 pm - 3:45 pm	"To Cleave or Not to Cleave: Lessons Learned from Protease Activators and Inhibitors"
3:45 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Proteases: Friends or Foes? Proteases in Immunology and Cancer. Discussion Leader:
5:30 pm - 5:50 pm	"SARS-CoV-2 Main Protease 3CLpro Disrupts Antiviral Autophagy by Cleaving Galectin-8"
5:50 pm - 6:00 pm	Discussion
6:00 pm - 6:20 pm	"Defeating an Antiviral Interferon Response by SARS-CoV-2 Main Protease 3CL^pro cleavage of IFN-?1"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:45 pm	"ClpP1 and ClpP1P2 Peptidases Control Alginate Overproduction and Other Virulence-Associated Phenotypes in Pseudomonas Aeruginosa"
6:45 pm - 6:50 pm	Discussion
6:50 pm - 7:05 pm	"Serine Hydrolases and Their Inhibitors in Colonic Inflammation and Colorectal Cancer"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:25 pm	"Detection of Tumor Markers in Breast Cancer Using Mass Cytometry"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Understanding and Targeting Proteases Discussion Leader:
9:00 am - 9:15 am	"Application of Activity-based Probes to Interrogate the Contribution of Cathepsin X to Dendritic Cells"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Lon Protease Processively Degrades Very Stable Model Substrates Characteristic of HCLR-clade AAA+ Proteases"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Chemoproteomic Profiling Identifies a Human DPP4 Homolog in the Gut Commensal Bacteroides thetaiotaomicron Important for Membrane Integrity"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Engineering a Membrane-Independent Human Prothrombinase Through Parsimonious Mutation of Factor Xa"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Dipeptidyl Peptidase 9 (DPP9) in Primary Human Blood Cells: an Exploration of Its Activity and Intracellular Localization"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Cytosolic Serpins Block Proteolysis of DOK3 by Cathepsin G to Regulate Macrophage Inflammation"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career Panel Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Mentoring Session: Science Career Options
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

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Proteolytic Enzymes and Their Inhibitors

June 21 - 26, 2026

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