Sunday evening
WATER-FORM, ROLE, SELECTIVITY ISSUES IN CONNECTION WITH MEMBRANE PROTEINS
- Discussion Leader: David Deamer, UC at Santa Cruz - Introduction
- G.Marius Clore, NIDDK - Water in hydrophobic cavities
- Mark S. P. Sansom, Oxford - Simulations on channel water vis a vis proton conductance
- Peter Agre, Johns Hopkins School of Medicine - Biophysical studies of aquaporin
Monday morning
MEMBRANE PROTEIN FOLDING
- Discussion Leader: Stephen White, UC at Irvine - Introduction
- Stuart McLaughlin, SUNY at Stony Brook - Interactions of charged peptides with charged membranes
- Barry Honig, Columbia - Free energy determinants of helix insertion into membranes
- Jeffrey Skolnick, Scripps Research Institute - Computer simulations of protein folding membranes
- Timothy Cross, Florida State U. - Gramicidin structure and assembly
Monday evening
ION-TRANSLOCATING CHANNELS AND TRANSPORTERS
- Discussion Leader: Etana Padan, Hebrew U. - Introduction
- Henry Lester, California Institute of Technology - Proton movements through gated ion channels
- Shimon Schuldiner, Hebrew U. - Structure/function studies of a small multidrug/H+ antiporter
- H. Ronald Kaback, HHMI, UCLA - Structural approaches to the Lac carrier
Tuesday morning
STRUCTURAL CORRELATES TO ENERGY-COUPLING BY ATP SYNTHASE
- Discussion Leader: Robert Fillingame, U. Wisconsin - Introduction
- Mark Girvin, Albert Einstein College of Medicine - Structural studies of the c-subunit using NMR spectroscopy
- Steven Vik, Southern Methodist U. - Membrane topology of the a-subunit of F0
- Roderick Capaldi, U. Oregon - "Stalking energy coupling in the F1F0
- Wolfgang Junge, U. Osnabruck - Does coupling involve rotation of F1?
Tuesday evening
INTEGRATION OF NEW STRUCTURAL INFORMATION INTO MODELS OF CYTOCHROME OXIDASE FUNCTION
- Discussion Leader: Shelagh Ferguson-Miller, Michigan State U. - Introduction
- Hartmut Michel, Max-Planck Institut - X-ray crystallographic studies of cytochrome oxidase
- Peter Rich, University College London - Charged-coupled proton movement in peroxidases and oxidases
- Gerald Babcock, Michigan State U. - Proton-controlled electron flow in cytochrome oxidase
Wednesday morning
THE PATH OF PROTONS THROUGH AND ON THE SURFACE OF BACTERIORHODOPSIN
- Discussion Leader: Menachem Gutman, Tel Aviv U. Introduction
- Yoshiaki Kimura, Biomolecular Engineering Inst., Osaka - Electron diffraction studies of 2-dimensional bacteriorhodopsin crystals
- Janos Lanyi, UC at Irvine - Studies of the proton path through bacteriorhodopsin
- Ernst Bamberg, Max-Planck Institut - Regulation of the photocycle by external electric field
- Norbert Dencher, Institute of Biochemistry, Darmstadt - Proton movement on the surface of bacteriorhodopsin
- Esther Nachliel, Tel Aviv U. - Proton movement on the surface of bacteriorhodopsin
Wednesday evening
PHOTOSYNTHETIC REACTION CENTER--WHAT ANSWERS YEARS AFTER THE SOLUTION?
- Discussion Leader: Marilyn Gunner, CCNY - Introduction
- C. Roy D. Lancaster, Max- Planck Institute - Structure and properties of the Qb site
- Mark Paddock, UCSD - Rate-limiting steps in reaction center function
- Colin Wraight, U. Illinois - Lessons learned from guided molecular approaches
Thursday morning
WORKSHOPS ON MAJOR CONFERENCE THEMES
- Workshop I: The structural and functional role of phopholipids in and bordering proton-translocating membrane proteins
- Chair: Steve White
Workshop II: Conceptual and technological issues involved in developing a detailed mechanism for proton-translocating proteins; what are they for redox-coupled complexes, light-coupled complexes, transporters, and ATPases, what are the commonalities vs the distinct issues for these categories?
- Chair: Peter Rich
- TBA (redox-coupled)
- Bill Cramer (light-driven)
- Rich Cross (ATPases)
- Shimon Schuldiner (Transporters)
Business meeting/Election of new Vice Chair
Thursday evening
COMPLEX III AND FANTASIA ON COMPLEX III
- Discussion Leader: William Cramer, Purdue U. - Introduction
- Di Xia, U. Texas Southwestern Medical Center - X-ray crystallographic studies of Complex III
- P. Leslie Dutton, U. Pennsylvania - Towards synthesizing proton-translocating enzymes
- Terry Krulwich - Closing comment
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