Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Developmental Biology of Erythropoiesis
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:00 pm
"Emergence of Definitive Hematopoiesis from Erythro-Myeloid Progenitors in the Mammalian Yolk Sac"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"A View of Human Hematopoietic Development and Disease from the Petri Dish"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"iPS Cells for the Blood Bank"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
"Globins and Global Gene Regulation: A Journey from Basic Research to Biomedical Applications"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Developmental Biology of Erythropoiesis / Erythroid Transcription: Lineage Specific Transcription Factors
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"Induction of Hematopoiesis During Zebrafish Development"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Transcriptional Control by Epo in Terminal Erythroid Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Insights into the Function of Setd8 and H4K20 Monomethylation in Terminal Erythroid Maturation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Validated Systematic Integration: A VISION for Epigenomics in Hematopoietic Gene
Regulation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Regulatory Network Control of Blood Cell Development"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Interactions Between EPO Signals, GATA1 and KLF1 in the Erythroid Cell Nucleus"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"From Ensembles to Single-Cells: A Window into Cis- and Trans- Epigenomic Variation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"FOXO3, Mitochondria and Regulation of Terminal Erythropoiesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Regulation of Fetal Hemoglobin Production by FOXO3"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Erythroid Transcription: Chromatin
7:30 pm - 7:45 pm
"HbF: Silencing and Approaches to Reactivate Expression in the Adult"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Deciphering the Hematopoietic Stem/Progenitor Cell Cistrome"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"CAPTURE the Erythroid Epigenome"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Chromatin Architecture in Erythroid Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Gene Regulation and Mutation in the 3-Dimensional Nucleus"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Enhancer Orientation and Transcriptional Regulation"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Erythropoiesis: Lineage
Commitment and Expansion
9:00 am - 9:15 am
"Genetic Insights into Human Erythropoiesis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Early Erythropoiesis Through the Lens of Single-Cell Transcriptomics"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"New Insights into Erythroid Progenitors"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Altered Function of Mutant KLF1/EKLF in Erythropoietic Onset"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Requirement for RASA3 in Blood Formation: Studies in scat and Rasa3 cKO Models"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Coupling Differences to Epo and G-CSF Receptors Dictates Outcomes of Activating JAK2 Mutants in Myeloproliferative Neoplasm"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Emergence of the Erythroid Fate from the Early Hematopoietic Hierarchy: A Single Cell RNA-Seq Approach"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Quantitative Mass Spectrometry and Single-Cell Mass Cytometry to Model Erythropoiesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Beta-Thalassemia Beyond the Erythropoietic Defect: Impaired Self-Renewal of Hematopoietic Stem Cell Within an Altered Bone Marrow Niche"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Erythropoiesis: Terminal Maturation
7:30 pm - 7:45 pm
"Remodeling of the Proteome in Reticulocytes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Nutrient Regulation of HSC Differentiation, Red Cell Style"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Nuclear Opening and Histone Release During Chromatin Condensation in Terminal Erythropoiesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Regulating Self-Renewal of BFU-E Progenitors - Repurposed Drugs for Epo-Resistant Anemias"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Exploring Intercellular Interactions Within Erythroblastic Islands"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"Hepcidin Contributes to Host Defense Against Gram-Negative Infections by Controlling Non-Transferrin-Bound Iron"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Iron Flux Through Ferritin During Erythrocyte Development"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"A Dominant Mutation in Mitochondrial Unfoldase CLPX Contributes to Erythropoietic Protoporphyria"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Unexpected Role of Ferroportin in Survival of Mature Red Cells and Protection from Malarial Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:40 am
"Integrated Stress Response of Heme-Regulated eIF2alpha Kinase in Erythropoiesis"
10:40 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:30 am
"Liver Endothelial Cells in Iron Sensing and Hepcidin Regulation"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Heme Signaling and Diamond Blackfan Anemia"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Diamond Blackfan Anemia: Many Ways for Erythropoiesis to Fail"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variants of Red Blood Cell Traits"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Structure and Function
7:30 pm - 7:45 pm
"Band 3 Function and Dysfunction in a Structural Context"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Ankyrin-B Metabolic Syndrome: A New Cell-Autonomous Mechanism for Obesity with Public Health Implications"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Mechanism of O2 Regulation of Red Cell Properties"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Erythroblast Enucleation Depends upon F-Actin Regulation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Proteomic Study of Erythroid Differentiation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Marker of Self CD47 Structure-Function in Relation Blockade "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Red Cell Disorders: Genetics, Mechanisms and Innovative
Treatments
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"HSP70, One of the Major Key Factors in Diamond-Blackfan Anemia Pathophysiology"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Gene Editing to Ameliorate Globinopathies"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Induction of Stress Erythropoiesis by Inflammation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Pomalidomide and Dexamethasone and Their Effects on Erythropoiesis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"In Vivo Gene Editing for Hemoglobin Disorders via PNA Nanoparticles"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"New Molecular Insights that Determine the Control of Apoptosis Versus Differentiation in Normal and Pathological Erythropoiesis: Potential Therapeutic Implications"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"The SCD Biochip: Measuring Abnormal RBC Adhesion During Day-to-Day Clinical Care"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"PO2 Regulated Red Blood Cell (RBC) Deformation in Capillary Flow"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Sickle Hemoglobin Polymerization During Hypoxic Sequestration Hinders Plasmodium falciparum Growth"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Red Cell Disorders: Infections
7:30 pm - 7:45 pm
"Targeting Erythrocyte Deformability to Block Malaria Parasite Transmission"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Targeting Red Blood Cell Determinants of Malaria Infection"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"New Insights on How Malaria Parasites Target Reticulocytes and Modify Them Post Invasion"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Systematic Extracellular Receptor Interaction Screens to Determine the Molecular Basis of Erythrocyte Invasion by Plasmodium Parasites"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Crosstalk Between the Gut Microbiota and Blood Stage Malaria"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Functional Characterization of Hrg1 in Zebrafish"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Delineating the Functions of EKLF During Erythroid Terminal Differentiation"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure